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Novel dendritic macromolecule and its preparation method and use

A dendritic and macromolecular technology, applied in sexual diseases, drug combinations, etc., can solve the problems of inefficiency, tedious operation, time-consuming and labor-intensive consumables, etc., and achieve the improvement of egg fertilization rate, increase egg fertilization rate, and great social significance. and scientifically meaningful effects

Inactive Publication Date: 2015-11-25
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The success rate of in vitro fertilization is only about 50%, and the operation is cumbersome, which cannot be efficient and time-consuming and labor-intensive.

Method used

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  • Novel dendritic macromolecule and its preparation method and use
  • Novel dendritic macromolecule and its preparation method and use
  • Novel dendritic macromolecule and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1) The dendrimer polyamide-amine G3 (commercially available) with S-S as the core was catalyzed by sodium bisulfite (commercially available) at 20 degrees Celsius for 24 hours in dichloromethane and methanol (1:1) solution Reductive decomposition into half dendrimer G with SH bond activity 3 ;

[0050]

[0051] revert to

[0052]

[0053] 2) 1 mole of the branched compound Linker (commercially available or prepared) is mixed with 1 mole of polyethylene with a carboxyl group at one end and a methoxy group at the other end at a pH of 7.5 and at room temperature. Diol (commercially available) was reacted for 20 hours to generate compound B with a branched structure through reaction coupling, which was then lyophilized for use;

[0054]

[0055] +

[0056]

[0057]

[0058]

[0059] n is approximately equal to 100.

[0060] 3) One mole of compound B and two moles of compound A were reacted overnight in a solution of N,N'-dicyclohexylcarbodiimide and ch...

Embodiment 2

[0068] 1) Reductively decompose the S-S-centered dendrimer polyamide-amine G2 (commercially available) in dimethyl sulfoxide solution under the catalysis of vitamin C (commercially available) at 15 degrees Celsius for 24 hours to form SH Healthy active half dendrimer G2;

[0069]

[0070] reduction

[0071]

[0072] 2) 1 mole of the branched compound LinkerA (commercially available and can also be prepared) is catalyzed by N,N-dimethylformamide and trifluoroacetic acid by adding acetic anhydride to generate LinkerB (commercially available), and then LinkerB is in Under the condition of pH 6.5, react with 1 mole of polyethylene glycol (commercially available) with an amino group at one end and a methoxy group at the other end at room temperature for 24 hours for reaction coupling to generate compound B with a branched structure, Then freeze-dry for later use;

[0073] (linkerA)

[0074] TFA; anhydr; DMF

[0075] (linkerB)

[0076]

[0077] +

[0078]

...

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PUM

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Abstract

The invention discloses a preparation method and use of a novel tadpole-shaped compound containing a dendritic macromolecule. The novel tadpole-shaped compound has the dendritic macromolecule as a head and the chain-type hydrophilic compound as a tail. The invention discloses the preparation method and use of the novel tadpole-shaped compound. The novel tadpole-shaped compound can be fertilized in human or animal bodies in a normal fertility process and improves and an ovum fertility rate by at least three times.

Description

technical field [0001] The invention discloses the preparation and application of a novel tadpole-shaped compound containing dendritic macromolecules. The tadpole-shaped compound is a compound with a dendritic macromolecule as the head and a hydrophilic chain compound as the tail. The present invention The invention discloses its preparation method and application. The tadpole-shaped compound can increase the fertilization rate of eggs by more than 3 times during in vivo fertilization of humans or animals, that is, normal reproductive process. Background technique [0002] At present, due to environmental pollution and increasing life pressure, the infertility rate of young couples has increased significantly, which not only troubles some families, but also brings great instability to the society. Some endangered wild animals have become extinct due to their inability to effectively conceive. The success rate of in vitro fertilization only stays at about 50%, and the opera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K31/795A61P15/08
Inventor 韩冰高洁
Owner 韩冰