Method for identifying pharmaceutic adjuvants added in cordyceps sinensis product

Abstract

The invention discloses a method for identifying pharmaceutic adjuvants added in a cordyceps sinensis product. The method includes the following steps that the cordyceps sinensis product is ground into fine powder, and an iodine test solution is dropwise added after the fine powder is dissolved in water; if the solution is blue or black blue, a 20% sulfuric acid aqueous solution is added, water bath and centrifuging are carried out, and if the solution is not blue or black blue, water bath and centrifuging are directly conducted; an iodine test solution is dropwise added in supernate, and a zinc chloride iodine test solution is added in lower-layer precipitates. According to the method, expensive analyzers are not needed in the identifying process, and the method is simple, quick and effective. In the whole identifying process, whether the three adjuvants including starch, povidone and microcrystalline cellulose exist in the cordyceps sinensis product or not can be judged at the same time through one-time sampling.

Description

technical field [0001] The invention relates to an identification method for adding medicinal excipients to Cordyceps sinensis products. Background technique [0002] Cordyceps sinensis is a rare and precious medicinal material in my country. It has a long history of consumption in China. It is mainly used for kidney deficiency, impotence and nocturnal emission, waist and knee pain, chronic cough due to deficiency and asthma, and cough and hemoptysis. Because of its good medicinal efficacy and health care value, it is highly sought after by people. At present, many cordyceps sinensis tablets on the market are claimed to be pure cordyceps sinensis powder tablets. However, since cordyceps sinensis pure powder contains more fibers and oily components, the compressibility is not ideal, which directly leads to poor tableting effect of cordyceps sinensis powder and poor product hardness. High, easy to flake, splinter or loose, and the yield is very low. Therefore, auxiliary mate...

AI Technical Summary

Problems solved by technology

[0003] There are few methods for identifying the three excipients of starch, povidone and microcrystalline cellulose in Cordyceps sinensis products. The general method can only identify one of the excipients at a time. At present, there is no literature report that can simultaneously identify whether it is added by a single sampling The method of two or three excipients

And single sampling identification is faced with the mutual interference problem of various auxiliary materials identification, as: (1) starch aqueous solution meets iodine test solution and turns blue or blue black, and microcrystalline cellulose aqueous solution reacts with zinc chloride iodine test solution to form insoluble Blue floc of water, when the two exist at the same time, the blue floc cannot appear in blue or blue-black solution, and starch will interfere with the judgment of the presence or absence of microcrystalline cellulose

(2) Povidone reacts with iodine test solution to produce a reddish-brown precipitate. After shaking well, the precipitate dissolves into a reddish-brown solution; The blue or blue-black solution makes it impossible to observe the reddish-brown precipitate, and the starch will interfere with the judgment of the presence or absence of povidone

(3) When microcrystalline cellulose and povidone exist at the same time, after adding zinc chloride iodine test solution, blue insoluble flocs and reddish-brown precipitates are mixed, and it is impossible to clearly determine the presence or absence of the two, and povidone will interfere with microcrystalline cellulose. Judgment of presence or absence of crystalline cellulose