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Application of secreted factor grem2 in preparation of screening reagents for obesity diseases

A secreted factor and disease screening technology, applied in material separation, material analysis, biological testing, etc., can solve the problems of no GREM2, lack of clinical significance to carry out related research, and no report of serum level detection of GREM2

Active Publication Date: 2018-01-12
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Is GREM2 associated with obesity, does it play a role in beige adipose tissue, and which BMP does it antagonize? Most importantly, there is no research on GREM2 and energy metabolism in other studies, and there is no report on the detection of serum levels of GREM2, and no relevant research has been carried out on its clinical significance

Method used

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  • Application of secreted factor grem2 in preparation of screening reagents for obesity diseases
  • Application of secreted factor grem2 in preparation of screening reagents for obesity diseases
  • Application of secreted factor grem2 in preparation of screening reagents for obesity diseases

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Experimental program
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Effect test

Embodiment

[0017] 1. The level of serum GREM2 in obese patients is significantly higher than that in normal controls

[0018] In this study, from June 2013 to August 2014, 167 obese patients who met the indications and were treated in this hospital were enrolled in the obesity clinic of the Department of Endocrinology, Ruijin Hospital, and 147 normal volunteers were recruited at the same time. . The inclusion criteria for obese patients are: BMI ≥ 30.0kg / m2, aged between 14-34 years old. Exclusion criteria: 1) Secondary obesity; 2) Application of endocrine hormone drugs (including oral contraceptives, glucocorticoids); 3) Taking hypoglycemic or blood lipid-lowering drugs; 4) Pregnant or lactating patients; 5) Severe patients with abnormal liver and kidney function; 6) patients with neurological or mental diseases.

[0019] In addition, we recruited 147 normal volunteers from the students of Shanghai Jiao Tong University School of Medicine. The inclusion criteria for normal recruitment...

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Abstract

The invention relates to the preparation of a reagent for disease screening, in particular to the application of secreted factor GREM2 in the preparation of a reagent for screening obesity diseases. The present invention first finds out from the serum detection of normal people and obese patients that with the increase of BMI level, insulin resistance index and metabolic syndrome components, the serum GREM2 level is also higher. Further multiple linear regression results showed that serum GREM2 levels were positively correlated with body mass index and waist circumference, and after correcting a series of confounding factors, the correlation still existed independently and significantly. In vitro studies have shown that GREM2 can significantly inhibit the browning process of white fat. Therefore, the fat secretion factor GREM2 can be used as a serological marker of obesity and used to predict obesity and related chronic complications, providing a theoretical basis for clinically evaluating the risk of obesity and metabolic syndrome.

Description

technical field [0001] The invention relates to the preparation of a reagent for disease screening, in particular to the application of secreted factor GREM2 in the preparation of a reagent for screening obesity diseases. Background technique [0002] The widespread prevalence of overweight and obesity and their risk factors for various chronic diseases such as type 2 diabetes, cardiovascular disease, and tumors have made obesity a primary public health problem. China is in a period of rapid social and economic development, and the problems of obesity and related chronic disease complications are becoming increasingly prominent. According to the 2010 China Chronic Disease Surveillance and Diabetes Special Investigation Report jointly conducted by Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute of Endocrinology and Metabolic Diseases, and the Center for Chronic and Non-communicable Diseases Prevention and Treatment of the Chin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/76G01N30/02G01N33/66
Inventor 宁光洪洁王计秋刘瑞欣杨明兰
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE