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Application of Proteinase K in the Field of Skin Care and Cosmetics

A protease, cosmetic technology, used in cosmetics, cosmetic preparations, preparations for skin care, etc.

Active Publication Date: 2018-10-12
GPROAN BIOTECH (SUZHOU) INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although proteinase K has the above excellent activities, there are currently no reports of proteinase K being used in the beauty and cosmetics industry at home and abroad

Method used

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  • Application of Proteinase K in the Field of Skin Care and Cosmetics
  • Application of Proteinase K in the Field of Skin Care and Cosmetics
  • Application of Proteinase K in the Field of Skin Care and Cosmetics

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Experimental program
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Embodiment approach

[0017] According to another embodiment of the present invention, as long as the mutant proteinase K retains the activity of the natural proteinase K, the mutant proteinase K can be used to prepare a cosmetic composition for removing aged keratinocytes. According to some embodiments of the present invention, the proteinase K mutant may be the proteinase K mutant disclosed in CN102839165A, which has the following mutations on the basis of natural proteinase K:

[0018] (1) In the native protease K amino acid sequence (SEQ ID NO.2), Y at position 151 is mutated to A, K at position 208 is mutated to H, S at position 273 is mutated to T, and G at position 293 is mutated A, K at position 332 is mutated to R, S at position 337 is mutated to N; optionally, any one or more of the following mutations are also performed:

[0019] (2) Mutation of S at position 123 to A;

[0020] (3) The L at position 180 is mutated into I.

[0021] In the present invention, "123 bits", "151 bits", "180 ...

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Abstract

A use of protease K in the preparation of a cosmetic composition for removing aging keratinized cell, and the cosmetic composition comprising protease K as an active ingredient, wherein the amino acid sequence of protease K is shown as SEQ ID NO.2.

Description

technical field [0001] The invention relates to the application of natural protease K and protease K mutants in beauty and cosmetic industries. More specifically, the present invention relates to the application of natural protease K and genetically modified mutant recombinant protease K in cosmetic and cosmetic industries for removing aged keratinocytes. Background technique [0002] According to the "2013-2017 China Cosmetics Terminal Channel Construction and Investment Prospect Analysis Report" released by Qianzhan Industry Research Institute, from 2008 to 2012, the market size of my country's cosmetics industry showed an overall upward trend year by year. In 2008, the market size of my country's cosmetics industry was only 46.53 billion yuan; by 2012, it had risen to nearly 84.3 billion yuan, an increase of more than 80% within 5 years. In terms of growth rate, affected by the financial crisis, the growth rate in 2008 and 2009 was relatively slow, and the growth rate co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N9/50A61K8/66A61Q19/00A61Q19/08
CPCA61K8/66A61Q9/00
Inventor 安海谦鲁刚伟冉波任玉珍张贵财
Owner GPROAN BIOTECH (SUZHOU) INC