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Mycobacterium phlei oral administration nanoparticles and preparation method therefor

A technology of mycobacterium phlei and nanoparticles, applied in the field of medicine, can solve the problem of destroying the efficacy of mycobacterium phlei, achieve the effect of being suitable for large-scale production, easy production control, and avoiding discomfort reactions

Active Publication Date: 2016-01-06
CHONGQING LUMMY PHARMA
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Problems solved by technology

The inventors have found that general oral preparations can destroy the efficacy of Mycobacterium phlei, which is caused by the fact that Mycobacterium phlei will be directly decomposed by the digestive enzymes in the stomach after entering the gastrointestinal tract, so it cannot be absorbed into the blood circulation in the body to play a role. curative effect

Method used

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  • Mycobacterium phlei oral administration nanoparticles and preparation method therefor
  • Mycobacterium phlei oral administration nanoparticles and preparation method therefor

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preparation example Construction

[0041] The preparation method of the Mycobacterium phlei oral nanoparticle of the present invention comprises the following steps:

[0042] A, the carrier material is dissolved in an organic solvent to form an organic phase;

[0043] B, the mycobacterium phlei solution is added dropwise in the organic phase to form colostrum;

[0044] C. Add colostrum dropwise to the water phase to form double emulsion;

[0045] D. volatilize the organic solvent in the double emulsion, collect the solid matter by centrifugation, wash with distilled water, and obtain the oral nanoparticles of Mycobacterium phlei after drying.

[0046] Among them, the reasons for the selection of the conditions for forming colostrum, the conditions for forming double milk, the water phase, and the organic phase are as follows:

[0047] 1.1 Selection of methods for forming colostrum

[0048] Using the particle size and polydispersity coefficient of colostrum as an index, different methods are used to form colo...

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Abstract

The invention belongs to the medicine field, and concretely relates to mycobacterium phlei oral administration nanoparticles and a preparation method therefor. The provided nanoparticles employ a coating technology to coat mycobacterium phlei in a carrier material, after oral administration, degradation of gastrointestinal tract digestive enzymes to mycobacterium phlei can be avoided, after the medicine arrives at intestinal tracts, the medicine is absorbed by the intestinal tract lymph glands, and then is swallowed by macrophages, the medicine mycobacterium phlei is released and treatment effects are achieved. In addition, the mycobacterium phlei oral administration nanoparticles can achieve the almost same treatment effects as a mycobacterium phlei injection preparation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to oral nanoparticle of mycobacterium phlei and a preparation method thereof. Background technique [0002] Mycobacterium phlei is a multifunctional immune enhancer. Its main component is inactivated Mycobacterium phlei. It is a non-pathogenic bacterium to humans. It mainly regulates the immune function of the body through the immune response to achieve the purpose of treatment. . The cell wall components of Mycobacterium phlei induce non-specific immune stimulation and amplification. After entering the human body, it activates the body's immune system and achieves therapeutic effects. Mycobacterium phlei can be mainly divided into three modes: humoral immunity, cellular immunity, and macrophage action (Zhu Muyun et al., The value of Mycobacterium phlei in clinical application of tumors, 2008, P357). The effect on humoral immunity is mainly reflected in enhancing the activity o...

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Application Information

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IPC IPC(8): A61K35/74A61K9/14A61K47/34A61K47/32A61K47/24A61P37/04
Inventor 唐小海冉茂盛陈玉玺黄源芳邱宇
Owner CHONGQING LUMMY PHARMA
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