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Pharmaceutical composition for treating bedsores and preparing method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for treating decubitus and its preparation, can solve the problems of high treatment cost, long treatment time, slow healing, etc., avoid re-infection, and the preparation method is simple and easy, and has no toxic and side effects. small effect

Inactive Publication Date: 2016-02-03
叶宗耀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings of slow healing, long treatment time and high treatment cost in the medicine for treating bedsore in the prior art, the purpose of the present invention is to provide a pharmaceutical composition for treating bedsore to solve the above problems

Method used

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  • Pharmaceutical composition for treating bedsores and preparing method thereof
  • Pharmaceutical composition for treating bedsores and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The pharmaceutical composition of Example 1 of the present invention includes the following preparation raw materials in parts by weight: Radix Ophiopogon 20, Eucalyptus 15, Centella asiatica 10, Rhizoma Chuanxiong 15, Angelica sinensis 10, Lycium barbarum 10, Galangal 10, Radix radix 5, Burnet 5 , fresh rehmannia 10 and licorice 5.

[0035] The preparation method is as follows: take Radix Ophiopogon japonicus, pulverize into a coarse powder, place in a supercritical carbon dioxide extraction device, add a 75% ethanol solution with a volume fraction of 45% of the weight of the coarse powder, control the flow rate of carbon dioxide to 18L / h, and extract the pressure to 16MPa, the extraction temperature is 50°C, the extraction time is 2h, and the extract of Ophiopogon japonicus is obtained by decompression separation, and the residue of Ophiopogon japonicus is retained; Eucalyptus leaves, Centella asiatica and Chuanxiong are weighed, mixed, crushed, and added to 5 times th...

Embodiment 2

[0037] The pharmaceutical composition of Example 2 of the present invention includes the following preparation raw materials in parts by weight: Radix Ophiopogon 25, Eucalyptus 20, Centella Asiatica 15, Rhizoma Chuanxiong 18, Angelica 12, Wolfberry 15, Galangal 12, Radix Radix 8, Burnet 10 , fresh rehmannia 12 and licorice 10.

[0038] The preparation method is similar to that of Example 1, and an ointment is made.

Embodiment 3

[0040] The pharmaceutical composition of Example 3 of the present invention includes the following preparation raw materials in parts by weight: Radix Ophiopogon 30, Eucalyptus 25, Centella Asiatica 20, Rhizoma Chuanxiong 20, Angelica sinensis 15, Lycium barbarum 18, Galangal 18, Radix radix 10, Burnet 15 , fresh rehmannia root 15 and licorice 15.

[0041] The preparation method is similar to that of Example 1, and a powder is made.

[0042] Pharmacodynamic experiment

[0043] one, Medicinal composition of the present invention treats guinea pig bedsore model test

[0044] 1. Test material:

[0045] 1.1. Experimental animals: male guinea pigs, weighing (250±25) g, provided by the Animal Experiment Center of Nanjing Medical University.

[0046] 1.2. Experimental drug: the ointment for treating bedsore prepared in Example 1, Mayinglong Musk Hemorrhoid Ointment (National Medicine Accreditation: Z42021920).

[0047] 2. Animal model establishment: 60 guinea pigs were anesthet...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating bedsores and a preparing method thereof. The pharmaceutical composition is prepared from, by weight, 20-30 parts of radix ophiopogonis, 15-25 parts of folium eucalypti, 10-20 parts of centella asiatica, 15-20 parts of ligusticum wallichii, 10-15 parts of angelica sinensis, 10-18 parts of lycium barbarum, 10-18 parts of galangal, 5-10 parts of ampelopsis japonica, 5-15 parts of sanguisorba officinalis, 10-15 parts of radix rehmanniae recens and 5-15 parts of liquorice. The formula of the traditional Chinese medicine is reasonable, synergistic effect is good, the traditional Chinese medicine can clear heat for detoxication, activate blood circulation to remove stasis, clear away decay and toxicity, and promote tissue and skin regeneration, blood vessels and meridians are unblocked while decay and toxicity are cleared away, autophage of skin can be accelerated, toxin and bacteria can be discharged out of open sores quickly, the immunity of the organism is improved, resistance to bacteria and fungi is improved, and reinfection after wound healing is avoided.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating decubitus and a preparation method thereof. Background technique [0002] Decubitus ulcers, also known as pressure sores or pressure ulcers, are local tissue ulcers and necrosis caused by continuous ischemia, hypoxia, and malnutrition caused by constant pressure on local tissues. It is one of the common clinical complications. Traditional Chinese medicine is called "Xi sore", which is caused by long-term illness, great loss of qi and blood, long-term bed rest, local pressure, resulting in abnormal blood and qi circulation, blockage of meridians and collaterals, and no skin. In severe cases, it can cause sepsis and lead to death. [0003] Compared with Chinese patent medicines, traditional western medicine often uses disinfectants or antibiotics when changing dressings. Although it can effectively control...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P17/02
Inventor 叶宗耀
Owner 叶宗耀