Agent for promoting in vivo absorption of hydroxytyrosol and derivatives thereof and use of same
A technology of hydroxytyrosol and derivatives, applied in the field of in vivo absorbable compositions, can solve problems such as not yet reported, and achieve the effects of inhibiting the accumulation of body fat, inhibiting the increase of blood sugar, and inhibiting the increase of blood pressure
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Embodiment 1
[0108] Example 1: The effect of EGCG on the in vivo absorbability of hydroxytyrosol among compounds having a galloyl group was investigated. At the same time, the influence of EGC without galloyl group on the in vivo absorbability of hydroxytyrosol was also studied. By comparing the results with the control and EGCG, it was studied whether galloyl group is related to the in vivo absorbability of hydroxytyrosol.
[0109]SD (IGS) male rats (5 weeks old) were purchased from Oriental BioService Co., Ltd., and after one week of adaptive training in the test environment, animals showing smooth development were selected for the test. The rats fasted overnight were divided into 3 groups, 4 or 5 in each group, and administered orally using a catheter. The first group (control) was 5 mL / kg of distilled water and 50 mg / 5 mL of distilled aqueous solution of hydroxytyrosol on the market. / kg, the second group is EGC distilled water 100mg / 5mL / kg and hydroxytyrosol distilled water 50mg / 5mL / k...
Embodiment 2
[0120] Example 2: The influence of OPC on the in vivo absorbability of hydroxytyrosol was studied.
[0121] SD (IGS) male rats (9 weeks old) were purchased from Oriental BioService Co., Ltd., and after one week of adaptive training in the test environment, animals showing smooth development were selected for the test. The rats fasted overnight were divided into 2 groups, 5 or 6 in each group, and administered orally using a catheter. The first group (control) was distilled aqueous solution of hydroxytyrosol 30mg / 5mL / kg, and the second group was hydroxytyrosol. Tyrosol 30mg / kg and grape seed extract 500mg / kg distilled water 5mL / kg. Before the administration and 0.25, 0.5, 1, 2, 3, and 6 hours after the start of the administration, blood was collected from the tail vein using heparin blood collection tubes, and plasma samples were obtained by centrifugation (8000 rpm, 10 minutes). The obtained plasma was deconjugated and deproteinized, and the obtained supernatant was concentra...
Embodiment 3
[0143] Example 3: It was examined whether the in vivo absorption-promoting effect of hydroxytyrosol was found similarly to Example 2 even if the usage-amount of the grape seed extract was reduced.
[0144] SD (IGS) male rats (9.5 weeks old) were purchased from Oriental BioService Co., Ltd., and after 2 weeks of adaptive training in the test environment, animals showing smooth development were selected for the test. The rats fasted overnight were divided into 3 groups, 4 in each group, and administered orally using a catheter. The first group (control) was 30 mg / 5 mL / kg of distilled aqueous solution of hydroxytyrosol, and the second group was hydroxytyrosol 30mg / kg and grape seed extract 150mg / kg in distilled water 5mL / kg, the third group is hydroxytyrosol 30mg / kg and grape seed extract 250mg / kg in distilled water 5mL / kg. Before the administration and 0.25, 0.5, 1, 2, 3, and 6 hours after the start of the administration, blood was collected from the tail vein using heparin bloo...
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