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A kind of preparation method of light-controlled drug release metal organic framework compound

A metal-organic framework and compound technology, which is applied in the field of preparation of light-controlled drug release metal-organic framework compounds, can solve the problems of low stability of metal-organic frameworks, difficulty in achieving controlled drug release, complicated system design, etc. Low, easy to operate and control, controlled drug release effect

Active Publication Date: 2018-03-27
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Metal-organic framework compounds mainly have the following problems in terms of drug release: first, some metal-organic frameworks are not stable under physiological conditions, and it is difficult to actually play a role; second, it is difficult for some systems to achieve controlled drug release. Organic framework compounds are only used as materials for adsorbing drugs; third, the system design is too complicated and the cost is high

Method used

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  • A kind of preparation method of light-controlled drug release metal organic framework compound
  • A kind of preparation method of light-controlled drug release metal organic framework compound
  • A kind of preparation method of light-controlled drug release metal organic framework compound

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Zirconium tetrachloride (23.1mg, 0.099mmol) and azo ligand (43.2mg, 0.099mmol) were dissolved in 6mL of N,N-dimethylamide, then 1.1mL of acetic acid was added to the above solution, and finally Place it in an oven at 100°C for 72 hours to obtain octahedral crystals; use N,N-dimethylamide to wash the crystals three times a day for two days, then soak the crystals in water for use;

[0030] The azo ligand is

[0031] (2) The drug to be adsorbed is made into an aqueous solution of the drug, and the crystal obtained in step 1 is taken out from the water outlet and immersed in the aqueous solution of the drug, and after soaking for 10-14 hours, a frame compound crystal having the drug adsorbed is obtained; the particle diameter of the drug is 0.5 -2nm;

[0032] (3) Wash the drug-adsorbed framework compound obtained in the previous step with water to remove the unadsorbed drug, then wash the crystal three times with a saturated aqueous solution of β-cyclodextrin, 25 mL...

Embodiment 2

[0034] (1) Zirconium tetrachloride (23.1mg, 0.099mmol) and azo ligand (38.9mg, 0.089mmol) were dissolved in 6mL of N,N-dimethylamide, then 1.1mL of acetic acid was added to the above solution, and finally Place it in an oven at 100°C for 72 hours to obtain octahedral crystals; use N,N-dimethylamide to wash the crystals three times a day for two days, then soak the crystals in water for use;

[0035] The azo ligand is

[0036] (2) The drug to be adsorbed is made into an aqueous solution of the drug, and the crystal obtained in step 1 is taken out from the water outlet and immersed in the aqueous solution of the drug, and after soaking for 10-14 hours, a frame compound crystal having the drug adsorbed is obtained; the particle diameter of the drug is 0.5 -2nm;

[0037] (3) Wash the drug-adsorbed framework compound obtained in the previous step with water to remove the unadsorbed drug, then wash the crystal three times with a saturated aqueous solution of β-cyclodextrin, 25 mL...

Embodiment 3

[0039] (1) Zirconium tetrachloride (23.1mg, 0.099mmol) and azo ligand (51.8mg, 0.119mmol) were dissolved in 6mL of N,N-dimethylamide, then 1.1mL of acetic acid was added to the above solution, and finally Place it in an oven at 100°C for 72 hours to obtain octahedral crystals; use N,N-dimethylamide to wash the crystals three times a day for two days, then soak the crystals in water for use;

[0040] The azo ligand is

[0041] (2) The drug to be adsorbed is made into an aqueous solution of the drug, and the crystal obtained in step 1 is taken out from the water outlet and immersed in the aqueous solution of the drug, and after soaking for 10-14 hours, a frame compound crystal having the drug adsorbed is obtained; the particle diameter of the drug is 0.5 -2nm;

[0042] (3) Wash the drug-adsorbed framework compound obtained in the previous step with water to remove the unadsorbed drug, then wash the crystal three times with a saturated aqueous solution of β-cyclodextrin, 25 mL...

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Abstract

The invention provides a preparation method for a light-control medicine-release metal organic frame compound. The preparation method comprises the following steps: azo ligand, acetic acid and zirconium tetrachloride are utilized to be dissolved in N,N-dimethyl formamide to obtain a metal organic frame, and then medicines and beta cyclodextrin are introduced so as to prepare the compound. Beta cyclodextrin can be combined with trans azo, so that the system does not release when not accepting the outside stimulus, and only release when accepting ultraviolet radiation or being added with amantadine, that is, the prepared metal organic frame compound can realize controllable medicine release.

Description

technical field [0001] The invention belongs to the technical field of porous material preparation and drug controllable release, and in particular relates to a preparation method of light-controlled drug release metal organic framework compound. Background technique [0002] Metal-organic framework compounds are periodic network structures obtained by coordination between metals or metal clusters and organic ligands. They have the characteristics of high specific surface area and adjustable pore size. They are currently widely used in the fields of gas adsorption, separation, catalysis, and drug release. . [0003] Metal-organic framework compounds mainly have the following problems in terms of drug release: first, some metal-organic frameworks are not stable under physiological conditions, and it is difficult to actually play a role; second, it is difficult for some systems to achieve controlled drug release. Organic framework compounds are only used as materials for adso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F7/00C07C245/08A61K41/00
CPCA61K41/00C07C245/08C07F7/003
Inventor 汪成孟祥士桂波
Owner WUHAN UNIV