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Clean production process of folic acid

A production process and clean technology, applied in the field of folic acid clean production process, can solve problems such as unfavorable human health and low yield, and achieve the effects of saving raw materials, improving purity, and saving steps and time.

Active Publication Date: 2018-01-30
QINGDAO LANGYATAI GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the above two methods all have low yields, and the organic wastewater produced by the folic acid production workshop contains a large amount of toxic and harmful substances, which is extremely harmful to human health.

Method used

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  • Clean production process of folic acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In the present invention, the clean production process of folic acid specifically comprises the following steps:

[0025] Step 1, the preparation of crude product,

[0026] Add 2,4,5-triamino-6-hydroxypyrimidine sulfate, p-aminobenzoyl glutamic acid and trichloroacetone in turn to the four-necked flask, the molar ratio of the three is 1:1:1, and turn on the stirrer , the reaction raw materials in the flask are stirred, after the three are mixed evenly, add alkaline sodium hydroxide liquid, the add-on of alkaline sodium hydroxide is 10% of raw material gross weight, the alkaline sodium hydroxide here is A solution with a mass fraction of 30% was reacted under alkaline conditions, the reaction temperature was 50° C., the pH was 2.0, and the reaction time was 10 hours to prepare a crude product;

[0027] Step 2, add sodium pyrosulfite to the crude product, the amount of sodium pyrosulfite added is 10% of the weight of the crude product, stir at 38°C for 0.5h, add dropwise...

Embodiment 2

[0034] In the present invention, the clean production process of folic acid specifically comprises the following steps:

[0035] Step 1, the preparation of crude product,

[0036] Add 2,4,5-triamino-6-hydroxypyrimidine sulfate, p-aminobenzoyl glutamic acid and trichloroacetone in turn to the four-necked flask, the molar ratio of the three is 1:1:1, and turn on the stirrer , the reaction raw materials in the flask are stirred, after the three are mixed evenly, add alkaline sodium hydroxide liquid, the add-on of alkaline sodium hydroxide is 10% of raw material gross weight, the alkaline sodium hydroxide here is A solution with a mass fraction of 30% was reacted under alkaline conditions, the reaction temperature was 55° C., the pH was 3.0, and the reaction time was 9 hours to prepare a crude product;

[0037] Step 2, add sodium pyrosulfite to the crude product, the amount of sodium pyrosulfite added is 10% of the weight of the crude product, stir at 38°C for 0.5h, add dropwise ...

Embodiment 3

[0044] In the present invention, the clean production process of folic acid specifically comprises the following steps:

[0045] Step 1, the preparation of crude product,

[0046] Add 2,4,5-triamino-6-hydroxypyrimidine sulfate, p-aminobenzoyl glutamic acid and trichloroacetone in turn to the four-necked flask, the molar ratio of the three is 1:1:1, and turn on the stirrer , the reaction raw materials in the flask are stirred, after the three are mixed evenly, add alkaline sodium hydroxide liquid, the add-on of alkaline sodium hydroxide is 10% of raw material gross weight, the alkaline sodium hydroxide here is A solution with a mass fraction of 30% was reacted under alkaline conditions, the reaction temperature was 60° C., the pH was 3.5, and the reaction time was 8 hours to prepare a crude product;

[0047] Step 2, add sodium pyrosulfite to the crude product, the amount of sodium pyrosulfite added is 10% of the weight of the crude product, stir at 40°C for 0.5h, add dropwise ...

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Abstract

The invention discloses a folic-acid cleaning production technology. The folic-acid cleaning production technology includes the steps that 2,4,5-triamino-6-hydroxy pyrimidine sulfate, p-amino benzamide glutamic acid and trichloroacetone are mixed and reacted under the condition that alkaline sodium hydroxide liquid exists, the reaction temperature ranges from 50 DEG C to 60 DEG C, pH ranges from 2.0 to 3.5, the reaction time ranges from 8 h to 10 h, and a crude product is obtained; sodium metabisulfite is added into the crude product and stirred for 0.5 h at the temperature of 38-40 DEG C, a sodium carbonate solution of 10% is added to keep pH ranging from 3 to 3.5 for 2 h, and first reaction liquid is obtained; the first reaction liquid is subjected to suction filtration, acid extracting, alkali refining and the like, and pure folic acid is prepared. By means of the folic-acid cleaning production technology, the yield of the prepared folic acid is 75% or above, and the purity is 95% or above.

Description

technical field [0001] The invention relates to the technical field of folic acid preparation, in particular to a clean production process of folic acid. Background technique [0002] Existing folic acid production technology is: first prepare intermediate product N-p-aminobenzoyl glutamic acid with p-nitrobenzoyl chloride and sodium glutamate, then prepare intermediate product 6 with methyl cyanoacetate, guanidine nitrate, sodium methylate -Hydroxy-2,4,5-triaminopyrimidine sulfate, and finally use the above two intermediate products to prepare crude folic acid, which is purified to obtain pure folic acid. It has been reported that the production of folic acid intermediate p-aminobenzoic acid by hydrogenation reduction method, the production of 2,4,5-triamino-6-hydroxypyrimidine sulfate by hydrogenation reduction method, and the production of trichloroacetone by tower chlorination method , and then use these three raw materials to produce folic acid. [0003] However, the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D475/04
CPCC07D475/04
Inventor 李悦明李霞徐建春王道会周爱军迟慎丽董婉刘国成
Owner QINGDAO LANGYATAI GRP
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