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A kind of production technology of blood coagulant

A technology of blood coagulation accelerator and production process, which is applied in the field of medicine and medicine, can solve the problems of harmful influence on the performance and quality of coagulation accelerator, interference detection effect, short shelf life, etc., and achieve good coagulation effect, low cost, and simple production process Effect

Active Publication Date: 2018-12-07
CHANGZHOU RUNDA TECH INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5) Effects on the essential components of blood: the use of coagulants cannot have harmful effects on the clinical test results of blood and the performance and quality of blood products
This blood coagulation accelerator can promote blood coagulation for up to 10 minutes, and has a short shelf life. During the long coagulation process, many additional effects will be produced to interfere with the detection effect

Method used

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  • A kind of production technology of blood coagulant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of pig brain powder: Wash 5000g of pig brain that meets the health and immunity requirements, wash it with detergent, and grind it into powder, soak it in 1500mL of ethanol (chemically pure) and 3000mL of n-hexane (chemically pure) at room temperature for 4 hours each, vacuum The solvent was removed by suction filtration, and the solid was fully washed alternately with ethanol (chemically pure) and n-hexane (chemically pure) to obtain about 4000 g of a light yellow solid crude product.

[0021] The crude product is extracted in batches with a Soxhlet extractor, and the solvent usage sequence is: 1) n-hexane (analytical pure); 2) ethanol (analytical pure); 3) ethanol (analytical pure)+n-hexane (analytical pure), The mixing volume ratio is 3:2.

[0022] Observe that the extractant that flows down after rinsing the material in the extraction chamber is basically colorless, then replace the next extraction solvent. After the extraction of the three solvents is ...

Embodiment 2

[0026] Preparation of pig brain powder: Wash 6000g of pig brain that meets the hygienic and immune requirements, wash it with detergent and grind it into powder, soak it in 1800mL of ethanol (chemically pure) and 3600mL of n-hexane (chemically pure) at room temperature for 5 hours each, vacuum The solvent was removed by suction filtration, and the solid was fully washed alternately with ethanol (chemically pure) and n-hexane (chemically pure) to obtain about 4500 g of a light yellow solid crude product.

[0027] The crude product is extracted in batches with a Soxhlet extractor, and the solvent usage sequence is: 1) n-hexane (analytical pure); 2) ethanol (analytical pure); 3) ethanol (analytical pure)+n-hexane (analytical pure), Mixing volume ratio 3:2;

[0028] Observe that the extractant that flows down after rinsing the material in the extraction chamber is basically colorless, then replace the next extraction solvent. After the extraction of the three solvents is complete...

Embodiment 3

[0032] Preparation of pig brain powder: Wash 8000g of pig brain that meets the health and immunity requirements, wash it with detergent, and grind it into powder, soak it in 2500mL of ethanol (chemically pure) and 5000mL of n-hexane (chemically pure) at room temperature for 6 hours each, vacuum The solvent was removed by suction filtration, and the solid was fully washed alternately with ethanol (chemically pure) and n-hexane (chemically pure), to obtain about 7000 g of a light yellow solid crude product.

[0033] The crude product is extracted in batches with a Soxhlet extractor, and the solvent usage sequence is: 1) n-hexane (analytical pure); 2) ethanol (analytical pure); 3) ethanol (analytical pure)+n-hexane (analytical pure), Mixing volume ratio 3:2;

[0034] Observe that the extractant that flows down after rinsing the material in the extraction chamber is basically colorless, then replace the next extraction solvent. After the extraction of the three solvents is comple...

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Abstract

The invention relates to the technical field of medicine, in particular to a production process of a blood coagulant. The production steps include: firstly preparing pig brain powder and an auxiliary formula in a weight ratio of 1:1, then mixing the two materials evenly; then subjecting the mixture to radiation sterilization; and finally under aseptic conditions, placing the mixture in a light isolated plastic or glass container to conduct sealing storage at room temperature. The blood coagulant prepared by the method can make use of the activation environment and condition for the auxiliary formula and pig brain powder to form blood coagulation factors together in a blood clotting process to excite and promote the start of blood clotting mechanism, thereby accelerating blood coagulation. The blood coagulant can achieve fast blood coagulation speed and good coagulation effect, also the production process is simple, environment-friendly, safe, and low in cost, and the raw material have wide sources, and are easily available, cheap and safe.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine, in particular to a production process of a blood coagulant. technical background [0002] The main function of blood coagulants is to accelerate blood coagulation, that is, to shorten the coagulation time of isolated blood without affecting the necessary components of blood, and to promote serum separation. The performance evaluation of this kind of coagulant should be considered from the following aspects: 1) Coagulant time: the time required for the blood to completely coagulate after contacting the coagulant. 2) Coagulation-promoting efficiency: the relative amount of coagulant that needs to be added to make the blood achieve the best coagulation-promoting effect. 3) Coagulation effect: the amount of exudation of serum after blood coagulation. 4) Separation effect: Whether the centrifuged blood after centrifugation can achieve complete and clear separation of serum, and whether...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/28
Inventor 袁东武
Owner CHANGZHOU RUNDA TECH INFORMATION CONSULTING CO LTD
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