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Application of reduced form of nicotinamide-adenine dinucleotid in preparation of drugs for inhibiting brain tissue inflammatory reaction and preventing or treating brain tissue inflammatory injury

A technology of nicotinamide adenine and dinucleotides, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, and can solve problems such as the undisclosed role of NADH treatment

Inactive Publication Date: 2016-06-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It has not been disclosed in the prior art that NADH has a therapeutic effect in inhibiting LPS-induced brain tissue inflammation and reducing brain tissue inflammatory damage

Method used

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  • Application of reduced form of nicotinamide-adenine dinucleotid in preparation of drugs for inhibiting brain tissue inflammatory reaction and preventing or treating brain tissue inflammatory injury
  • Application of reduced form of nicotinamide-adenine dinucleotid in preparation of drugs for inhibiting brain tissue inflammatory reaction and preventing or treating brain tissue inflammatory injury
  • Application of reduced form of nicotinamide-adenine dinucleotid in preparation of drugs for inhibiting brain tissue inflammatory reaction and preventing or treating brain tissue inflammatory injury

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Embodiment Construction

[0015] The experimental content of the present invention on the application of reduced nicotinamide adenine dinucleotide in the preparation of drugs for inhibiting brain tissue inflammation and reducing inflammatory damage mainly includes the following aspects:

[0016] 1. NADH has an inhibitory effect on the increase of brain tissue inflammation caused by Escherichia coli lipopolysaccharide.

[0017] 2. NADH has a protective effect on the increase of brain tissue apoptosis caused by Escherichia coli lipopolysaccharide.

[0018] The following pharmacodynamic experiments further illustrate that NADH has an obvious therapeutic effect in inhibiting the inflammatory response of brain tissue and reducing inflammatory damage.

[0019] 1. Experimental method

[0020] 1. Animal manipulation

[0021] In this study, mice were used for animal experiments and breeding at the MED-X Research Institute of Shanghai Jiaotong University. All operating procedures are in compliance with the Sh...

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Abstract

The invention discloses an application of a reduced form of nicotinamide-adenine dinucleotid (NADH) in preparation of drugs for inhibiting brain tissue inflammatory reaction and preventing or treating brain tissue inflammatory injury. Modern pharmacology experiments prove that NADH administration can obviously inhibit the brain tissue inflammatory reaction and reduce the brain tissue inflammatory injury, and suggest that prophylactic administration can inhibit brain tissue inflammation and prevent and treat the brain tissue inflammatory injury.

Description

technical field [0001] The invention relates to the application of reduced nicotinamide adenine dinucleotide in the field of pharmacy. More specifically, it is the application of reduced nicotinamide adenine dinucleotide in the preparation of drugs for inhibiting brain tissue inflammation and preventing or treating brain tissue inflammation damage. Background technique [0002] The chemical structural formula of reduced form of nicotinamide-adenine dinucleotide (NADH) is: [0003] [0004] The preparation method of NADH is mainly based on yeast as raw material, the yeast is extracted by boiling water, acidified and precipitated with lead acetate to obtain a crude product, which is processed and refined by formic acid type cation exchange resin column. [0005] Escherichia coli lipopolysaccharide (lipopolysaccharide from E.coli, referred to as LPS) is a lipopolysaccharide complex extracted from Escherichia coli, which is often used to induce inflammation models in experim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7084A61P25/00A61P25/28A61P25/16
Inventor 殷卫海王班曹威马英鑫丁显廷严整辉林利兴
Owner SHANGHAI JIAO TONG UNIV