Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of polyvinyl alcohol/poly-n-isopropylacrylamide temperature-sensitive core-shell microspheres

A technology of isopropylacrylamide and polyvinyl alcohol, which is applied in the field of preparation of polyvinyl alcohol/polyN-isopropylacrylamide temperature-sensitive core-shell microspheres, can solve problems such as insufficient temperature-sensitive characteristics, and achieve broad application Foreground effect

Inactive Publication Date: 2017-12-15
TECHN PHYSICS INST HEILONGJIANG ACADOF SCI
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of insufficient temperature-sensitive characteristics of existing microsphere materials, and provide the preparation of temperature-sensitive polyvinyl alcohol / polyN-isopropylacrylamide core-shell microspheres with uniform particle size and stable structure method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of polyvinyl alcohol/poly-n-isopropylacrylamide temperature-sensitive core-shell microspheres
  • Preparation method of polyvinyl alcohol/poly-n-isopropylacrylamide temperature-sensitive core-shell microspheres
  • Preparation method of polyvinyl alcohol/poly-n-isopropylacrylamide temperature-sensitive core-shell microspheres

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0014] Specific embodiment one: the preparation method of polyvinyl alcohol / polyN-isopropylacrylamide temperature-sensitive core-shell microspheres in this embodiment is realized according to the following steps:

[0015] 1. Mix the oil-soluble solvent and the emulsifier, and stir at room temperature until the emulsifier and the oil-soluble solvent are completely mixed to obtain the oil phase material;

[0016] 2. Add polyvinyl alcohol and N-isopropylacrylamide into deionized water according to the mass ratio of 1 to 30:10 to obtain a mixed reaction solution, then add 1mol / L hydrochloric acid and glutaraldehyde, and stir at room temperature until polyethylene Alcohol and N-isopropylacrylamide are completely dissolved to obtain a water phase material;

[0017] 3. Add the water-phase material dropwise to the oil-phase material under stirring at room temperature, stir until the water-phase material is evenly dispersed in the oil-phase material, heat in a water bath at 40-60°C for...

specific Embodiment approach 2

[0019] Embodiment 2: This embodiment is different from Embodiment 1 in that the oil-soluble solvent in step 1 is liquid paraffin, soybean oil or peanut oil. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0020] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the emulsifier described in Step 1 is Span 80, OP10 or a composite emulsifier of Span 80 and OP10. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing polyvinyl alcohol / poly-N-NIPAM temperature-sensitive core-shell micro-spheres, and relates to a method for synthesizing temperature-sensitive core-shell micro-sphere materials.By the aid of the method, the problem of insufficient temperature-sensitive characteristics of existing micro-sphere materials can be solved.The method includes firstly, mixing oil-soluble solvents and emulsifiers with one another to obtain oil-phase materials; secondly, preparing polyvinyl alcohol and N-NIPAM aqueous solution and adding hydrochloric acid and glutaraldehyde into the polyvinyl alcohol and N-NIPAM aqueous solution to obtain water-phase materials; thirdly, adding the water-phase materials into the oil-phase materials drop by drop, heating the oil-phase materials by means of water bath, then adding tetraethylenepentamine and dibenzoyl peroxide into the oil-phase materials, carrying out reaction for 1-6 hours and then cleaning and drying reaction products to obtain the temperature-sensitive core-shell micro-spheres.The method has the advantages that the core-shell micro-spheres prepared by the aid of the method are high in swelling speed and stable in structure just like polyvinyl alcohol micro-spheres and have temperature-sensitive characteristics of poly-N-NIPAM, and accordingly the method has a broad application prospect in the aspects of medicine loading, controlled release and the like.

Description

technical field [0001] The invention relates to a synthesis method of a temperature-sensitive core-shell microsphere material. Background technique [0002] The research and application of microsphere materials have developed very rapidly in recent years. Due to their special size and shape, microspheres have special functions that other materials do not have. The application of microspheres has penetrated into every corner of our lives, from Microsphere technology is used in bulk products such as coatings, paper surface coatings, and cosmetics, as well as high value-added products such as immobilized embolization therapy for biomacromolecules and cells, carriers for drug controlled release, and protein separation and utilization chromatography media. . [0003] Polyvinyl alcohol microspheres have the characteristics of non-toxicity, good biocompatibility and rapid swelling, and are widely used in drug controlled release carriers. With the application of smart materials in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08L33/24C08L29/04C08F120/54C08F261/04C08F220/54C08F2/32
CPCC08F2/32C08F120/54C08F261/04C08L33/24C08L29/04C08F220/54
Inventor 董伟周巍田波刘宇光侯静杨仲秋张晓东
Owner TECHN PHYSICS INST HEILONGJIANG ACADOF SCI