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Device for rapid detection and storage of samples and method of use thereof

A detection device and sample collection technology, applied in biological testing, material inspection products, etc., can solve problems such as false positives, false negatives, and affecting judgment results

Active Publication Date: 2019-04-09
ABON BIOPHARM HANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obtaining a broken test strip not only affects the judgment results of the naked eye, but also causes a lot of difficulties when using a machine to take a prescription, which will cause false positive and false negative results

Method used

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  • Device for rapid detection and storage of samples and method of use thereof
  • Device for rapid detection and storage of samples and method of use thereof
  • Device for rapid detection and storage of samples and method of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1——detection sensitivity experiment

[0064] The purpose of this example is to illustrate the detection sensitivity of the device and method of use of the present invention. Each sample solution was tested with ten devices for a total of 300 tests. The devices use a saliva sample to test, using test strips that have antigens from the drugs being tested. The test strip uses the competition method, with colloidal gold-labeled antibody in the label area and antigen on the test line.

[0065] The device simultaneously uses cocaine (COC), methamphetamine (MAMP), phencyclidine (PCP), tetrahydrocannabinol (THC) containing 0 times, 0.5 times, 1.5 times and 3 times the detection limit Morphine (MOP) or amphetamine (AMP) in PBS solution for detection. For example, the detection limit of THC in saliva is 4 ng / ml. Therefore, PBS solutions containing 0 ng / ml, 2 ng / ml, 6 ng / ml and 8 ng / ml of THC were tested. The table below shows the amount of drugs tested.

[0066...

Embodiment 2

[0070] Embodiment 2——Experiment on variability of sample volume range

[0071]This example is to illustrate the effect of the amount of sample on the use of the device of the present invention. The same drug sample in Example 1 was repeatedly detected 5 times with the detection device at 0 times, 0.5 times, and 3 times the concentration (prepared by using PBS as described above). The sample volumes are 100ul, 150ul, 200ul and 250ul respectively, and they are accurately added to the test device with a straw, instead of the sample collector, directly into the sample. 10 minutes after adding the sample, record the positive or negative result. Except for 0.5 times THC in 250ul (consistent results in 4 out of 5 tests), the results of the other tests were consistent in 5 replicates. Therefore, considering the amount of sample used, the present invention can provide correct results.

Embodiment 3

[0072] Example 3 - Pre-employment drug use screening

[0073] The present invention can also detect other detection items, such as the drug use screening experiment before employment. The tester puts the sample collector into the mouth, collects a saliva sample, and keeps the collector in the mouth for about 5 minutes. In one embodiment, the detection device includes a plurality of common drug test strips. Examples include cocaine, phencyclidine, THC, morphine, or amphetamines. These test strips employ a competitive immunoassay and contain labeled specific binding molecules (eg, antibodies) for each drug being tested in the labeled region of the test strip. The test line contains the antigen to be detected. If the sample contains an analyte, it binds to the labeled molecule that can specifically bind to the labeled region, preventing the labeled antibody from binding to the antigen on the test line. Therefore, when the analyte is present, there is no signal on the test l...

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PUM

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Abstract

The invention provides a device for rapidly detecting and preserving samples and a usage method thereof. The detection device comprises a testing cavity, a testing cavity inlet and a sample collecting cavity, wherein at least one testing element is arranged in the testing cavity. The detection device is characterized in that a sample collecting area of the testing element is completely and substantially exposed by the testing cavity inlet. When the detection device is used for detecting a sample, the line breaking defect can be effectively overcome.

Description

technical field [0001] The present invention relates to a device for collecting and rapidly detecting the presence of an analyte in a liquid sample. Background technique [0002] The following background art is provided to help the reader understand the present invention and is not to be admitted as prior art. [0003] Illegal drug abuse is a well-recognized and worsening social problem in our society. In 2003, the U.S. Department of Health and Human Services found that about 19.5 million Americans, or 8.2% of the population over the age of 12, were using illicit drugs. "Recent illicit drug use" refers to use of an illicit drug within the month preceding the investigation by the U.S. Department of Health and Human Services. Cannabis was found to be the most commonly used illicit drug, accounting for 6.2% (14.6 million). An estimated 2.3 million people (1.0%) are currently using cocaine, 604,000 have used crack, 1 million are using hallucinogens, and an estimated 119,000 a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/52
Inventor 沈丽荔伍欣金忠其
Owner ABON BIOPHARM HANGZHOU