Unlock instant, AI-driven research and patent intelligence for your innovation.

Bendazac lysine pharmaceutical composition and medical application thereof

A technology of benidalysine and composition, applied in pharmaceutical composition and its application field in protecting liver, can solve the problems such as the related report of benandalysine and pharmaceutical composition which have not been seen, and achieve outstanding performance. Substantial features, significant progress, effects of increased protection

Inactive Publication Date: 2016-08-24
陈斌
View PDF4 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between benzydaglysine and its pharmaceutical composition and liver protection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bendazac lysine pharmaceutical composition and medical application thereof
  • Bendazac lysine pharmaceutical composition and medical application thereof
  • Bendazac lysine pharmaceutical composition and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0023] Separation method: (a) Crush the dry tuber (2kg) of Corydalis Corydalis, extract with 85% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) 3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The ethyl acetate extract in (a) was removed with D101 type macroporous resin, first eluted with 30% ethanol for 6 column volumes, then eluted with 85% ethanol for 12 column volu...

Embodiment 2

[0027] Embodiment 2: pharmacological action

[0028] 1. Materials and methods

[0029] 1.1 Materials and Instruments

[0030] Bendaxyl lysine was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. ICR female mice weighing (25 ± 5) g, Shanghai Slack Laboratory Animal Co., Ltd.; Coomassie brilliant blue G-250, triglyceride kit, malondialdehyde test kit, glutathione peroxide kit, Alcohol dehydrogenase assay kit Nanjing Jiancheng Bioengineering Research Institute; Neptune Jinzun, Shenzhen Neptune Pharmaceutical Co., Ltd.; 56° Red Star Erguotou Liquor, Beijing Red Star Brewery. Alpha-D2 lyophilizer, Christ Company, Germany; electronic balance, Shanghai Tianping Instrument Factory; UV752N ultraviolet-visible spectrophotometer, Shanghai Yidian Analytical Instrument Co., Ltd.

[0031] 1.2 Animal grouping

[0032] 72 ICR mice were adaptively fed for one week...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses bendazac lysine pharmaceutical composition and medical application thereof. The bendazac lysine pharmaceutical composition comprises bendazac lysine and a novel-structured natural product compound (I) separated from the dried tubers of rhizoma corydalis. The bendazac lysine and the compound (I) can increase the GSH content in the liver tissue of a mouse, lower MDA content and inhibit TG accumulation and has a certain liver protecting effect when being used alone, and the liver protecting effect can be increased when the bendazac lysine and the compound (I) are used together. The bendazac lysine pharmaceutical composition can be developed into liver-protecting medicine and has outstanding substantial characteristics and evident progress as compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new application of bendalysine, in particular to a pharmaceutical composition of bendalysine and its application in protecting the liver. Background technique [0002] The chemical name of benzyl lysine is L-lysine (1-benzyl-1H-indazole-3-oxyl) acetate, which is an ophthalmic medicine and is suitable for early senile cataract. [0003] The metabolism and decomposition of alcohol are mostly completed in the liver, so drinking a lot of alcohol will bring a great burden to the liver. At the same time, many metabolites, such as acetaldehyde and free radical ions, will be produced in the process of alcohol metabolism. The damage of these metabolites to the body is greater than that of alcohol itself, which can cause inflammation, cause liver cell damage, reduce immune function, and lead to death. After the body ingests a large amount of ethanol, it is mainly oxidized to acetaldehyde under...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D303/04C07D301/32A61K31/416A61K31/336A61P1/16
CPCA61K31/336A61K31/416C07D301/32C07D303/04A61K2300/00
Inventor 陈斌
Owner 陈斌