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A kind of preparation method of litchi riboflavone

A technology of litchi kernel and flavonoids, which is applied in the industrial production of litchi kernel flavonoids and the field of preparation of litchi kernel flavonoids, can solve the problems of no litchi kernel flavonoid preparation method, difficulty in adapting to industrial requirements, and high preparation cost, and achieve high purity and avoid Damage, flavonoid yield increase effect

Inactive Publication Date: 2020-04-14
ZHONGSHAN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation cost of the above patents is high, the process is complicated, and it is difficult to adapt to the requirements of industrialization, and there is no relatively mature preparation method of litchi kernel flavonoids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of lychee kernel flavonoids, comprising the following steps:

[0021] (1) Pretreatment: lychee cores are cleaned, dried naturally, and the final moisture content is controlled below 10%;

[0022] (2) Crush: crush the dried lychee cores and pass through a 60-mesh sieve;

[0023] (3) Alkali treatment: After the lychee core is sieved, add 2 times the weight of water, adjust the pH to 8.5 with NaOH, and soak for 1 hour; % sodium carbonate solution soaked for 12 hours, its weight part is 1 times of litchi core weight part, during soaking, fully stir once every 2 hours, drain water after soaking;

[0024] (4) Extraction: Use ethanol solution with a volume fraction of 60%, adjust the pH to 7.5 with NaOH, and reflux at 50°C for 2 hours; extract the residue twice;

[0025] (5) Purification: Combine the extracts and concentrate in vacuum until most of the ethanol volatilizes; put it into a macroporous resin column by wet method, first elute with water and 1...

Embodiment 2

[0027] A preparation method of lychee kernel flavonoids, comprising the following steps:

[0028] (1) Pretreatment: lychee cores are cleaned, dried naturally, and the final moisture content is controlled below 10%;

[0029] (2) Crush: crush the dried lychee cores and pass through a 60-mesh sieve;

[0030] (3) Alkali treatment: After the lychee core is sieved, add 4 times the weight of water, adjust the pH to 10 with NaOH, and soak for 3 hours; % sodium carbonate solution was soaked for 24 hours, and its weight part was 2 times of litchi core weight part, during soaking, fully stirred once every 4 hours, drained after soaking;

[0031] (4) Extraction: Use an ethanol solution with a volume fraction of 80%, adjust the pH to 8 with NaOH, and reflux at 70°C for 5 hours; extract the residue 3 times;

[0032] (5) Purification: Combine the extracts and concentrate in vacuum until most of the ethanol volatilizes; put it into a macroporous resin column by wet method, first elute with ...

Embodiment 3

[0034] A preparation method of lychee kernel flavonoids, comprising the following steps:

[0035] (1) Pretreatment: lychee cores are cleaned, dried naturally, and the final moisture content is controlled below 10%;

[0036] (2) Crush: crush the dried lychee cores and pass through a 60-mesh sieve;

[0037] (3) Alkali treatment: After the lychee core is sieved, add 3 times the weight of water, adjust the pH to 9 with NaOH, and soak for 2 hours; % sodium carbonate solution was soaked for 18 hours, and its weight part was 1.5 times of litchi core weight part, during soaking, fully stirred once every 3 hours, drained after soaking;

[0038] (4) Extraction: use ethanol solution with a volume fraction of 70%, adjust the pH to 7.7 with NaOH, reflux at 60°C for 3.5 hours; extract the residue twice;

[0039] (5) Purification: Combine the extracts and concentrate in vacuum until most of the ethanol volatilizes; put it into a macroporous resin column by wet method, first elute with wate...

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PUM

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Abstract

The invention discloses a preparation method of litchi seed flavonoids, and belongs to the technical field of preparation method of active components. The preparation method comprises the steps: (1) pretreatment, (2) crushing, (3) alkali treatment, (4) extraction and (5) purification. The method is simple in process, low in cost and suitable for industrialized production; and the prepared litchi seed flavonoids are high in purity and good in activity.

Description

technical field [0001] The invention relates to a preparation method of litchi kernel flavonoids, in particular to a preparation method suitable for industrial production of litchi kernel flavonoids, and belongs to the technical field of active ingredient preparation. Background technique [0002] Flavonoids are a class of compounds that exist in nature and have a 2-phenylchromone (flavone) structure. Most plants contain flavonoids, which play an important role in plant growth, development, flowering, fruiting, antibacterial and disease prevention. A large number of studies have shown that flavonoids have anti-oxidation, anti-tumor, anti-aging and hypoglycemic, hypotensive, hypolipidemic, anti-inflammatory and analgesic effects, so they have received widespread attention at home and abroad. At present, the main extraction methods of flavonoids are: ultrasonic extraction, organic solvent extraction, cellulase extraction, etc., the most widely used is organic solvent extracti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/77A61K131/00
CPCA61K36/77A61K2236/331A61K2236/333A61K2236/39A61K2236/55
Inventor 韩淑琴吴丽李吉昌
Owner ZHONGSHAN POLYTECHNIC