Glucosamine-behenic acid grafting substance and preparation method
A technology of glucosamine and ‐behenic acid, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problems of increasing the water solubility, poor water solubility, and low bioavailability of poorly soluble drugs, and achieves The effect of ideal biodegradability, no pollution to the environment, and simple treatment process
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Embodiment 1
[0023] Accurately weigh 5 mg of the glucosamine-behenic acid graft provided by the present invention, add it to 5 mL of deionized water, and dissolve it ultrasonically in a water bath to obtain a glucosamine-behenic acid graft micelle solution, which is measured with a Malvern laser particle size potentiometer The number average particle size is 55nm, see figure 1 .
Embodiment 2
[0025] Accurately weigh 4 mg of valproic acid, dissolve it in 4 mL of ethanol, add it to a 25 mL rotary evaporator, then add 20 mg of glucosamine-behenic acid graft, and dissolve it ultrasonically in a water bath. The ethanol was removed by rotary evaporation, and the obtained solid was sonicated with 20 mL of water, namely drug-loaded micelles-1. The number-average particle diameter measured with a Malvern laser particle size potentiometer is 29nm, see figure 2 .
Embodiment 3
[0027] Accurately weigh 10 mg of valproic acid, dissolve it in 4 mL of ethanol, add it to a 25 mL rotary evaporator, then add 20 mg of glucosamine-behenic acid graft, and dissolve it ultrasonically in a water bath. The ethanol was removed by rotary evaporation, and the obtained solid was sonicated with 20 mL of water, namely drug-loaded micelles-2. The number-average particle diameter measured with a Malvern laser particle size potentiometer is 102nm, see image 3 .
[0028] Adopt high performance liquid chromatography to measure its encapsulation efficiency and drug loading capacity, the chromatographic conditions are as follows: mobile phase: (tetrabutylammonium bromide (5mmol / L)-potassium dihydrogen phosphate (20mmol / L)):methanol=25: 75, pH=3.6; column temperature 40°C; detection wavelength 216nm; injection volume 20μL. Adopt standard curve method to measure valproic acid content, standard curve preparation method is as follows: prepare the valproic acid solution of 500 μ...
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