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Application of bavachalcone and analogues thereof

A technology of psoralen chalcone and its analogues, which is applied in the field of medicine and can solve the problems that there are no reports of other uses of psoralen chalcone and its analogues

Inactive Publication Date: 2016-10-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It was isolated from Psoralea corylifolia for the first time in 2005 by Ming Hong Lee et al. and named Bavachalcone. Its CAS number is 28448-85-3 and its molecular formula is: 20 h 20 o 4 , molecular weight: 324.4, chemical structural formula: Existing studies only show that psoralen chalcone and its analogues have good antibacterial activity against a variety of common plant diseases, and so far there has been no report on other uses of psoralen chalcone and its analogues

Method used

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  • Application of bavachalcone and analogues thereof
  • Application of bavachalcone and analogues thereof
  • Application of bavachalcone and analogues thereof

Examples

Experimental program
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Effect test

Embodiment

[0052] 1. Experimental materials and equipment

[0053] 1.1 Experimental reagents

[0054]Cell line: HUVEC cell line was purchased from ATCC Company of the United States (HUVEC, CRL-1730).

[0055] Antibody: HRP-conjugated Monoclonal Mouse Anti-glyceraldehyde-3-phosphate Dehydrogease (GAPDH, KC-5G5) was purchased from Shanghai Kangcheng Biological Co., Ltd.; Anti-RORαantibody (ab60134) was purchased from abcam company.

[0056] Kit: the Promega Luciferase Assay System (Promega, USA); High-Capacity cDNA Reverse Transcription Kits were purchased from Applied Biosystems.

[0057] Reagents: Trizol Reagent was purchased from Invitrogen, USA; 15596-026 was purchased from Applied Biosystems; RIPA lysate (weak, P0013D), BCA protein concentration assay kit (enhanced, P0010), Triton X-100 / Triton X -100 (ST795), phenylmethylsulfonyl fluoride PMSF (100mM, ST506) were purchased from Beyontian Institute of Biotechnology; sodium dodecyl sulfate (sodium dodecyl sulfate, SDS), β-mercaptoetha...

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Abstract

The invention discloses a use of psoralen chalcone and its analogues. The use refers to the use of psoralen chalcone or / and its analogues as active ingredients for the preparation of activating retinoic acid-related orphan nuclear receptors. Body-alpha composition. The research results of the present invention show that psoralen chalcone and its analogs can directly activate the activity of RORα in a dose-dependent manner, and activate the expression of RORα protein and RORα mRNA in a concentration-dependent manner, and can effectively regulate its downstream biological clock genes The expression of BMAL1 indicates that psoralen chalcone and its analogues are good positive activators of RORα, which can be used to prevent or treat related diseases mediated by RORα, and have broad application prospects.

Description

technical field [0001] The invention relates to the application of psoraleachalcone and its analogues, belonging to the technical field of medicine. Background technique [0002] Orphan nuclear receptors are a large class of nuclear receptors for which no natural ligands have been found and identified. Retinoic acid-related orphan receptor-α (Retinoic acid-related orphan receptorα, RORα) is widely distributed in various tissues of the body, and is a transcriptional regulator belonging to the steroid hormone receptor superfamily member, which can directly enter the nucleus to regulate target Gene transcription, thus participating in the regulation of many important physiological processes, plays an important role in morphological development, cell proliferation and differentiation, body homeostasis maintenance, biological metabolism regulation, advanced nerve function control, and immune regulation. [0003] Studies have found that RORα is related to many diseases and can be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P9/12A61P9/10A61P3/10A61P3/06A61P3/04A61P1/16A61P25/28A61P19/02A61P19/10A61P35/00A61P35/02A61P29/00A61P11/00A23L1/30
Inventor 许锦文党延启凌霜
Owner SHANGHAI UNIV OF T C M
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