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Method for preparing PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials

A PLGA-HA-PVA, artificial technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of poor affinity of artificial cartilage materials, poor microscopic pore structure, etc. Surrounding organization integration ability, easy to implement effect

Inactive Publication Date: 2016-10-26
胡懿郃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the defects of poor microscopic pore structure and poor affinity of artificial cartilage materials in the existing artificial cartilage, the purpose of the present invention is to provide a new gradient PLGA-HA-PVA with good biocompatibility and similar biomechanical properties to cartilage The scaffold modified HA-PVA artificial cartilage material, its core area meets the biomechanical requirements and can completely replace the cartilage function. Cartilage can replace the load-bearing basis of cartilage and can be well integrated with surrounding tissues

Method used

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  • Method for preparing PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials
  • Method for preparing PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials
  • Method for preparing PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials

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Embodiment 1

[0033]1) Preparation method of HA-PVA primary emulsion: Weigh a certain amount of PVA and n-HA powder into a beaker, add the corresponding amount of double distilled water, place it on a constant temperature magnetic stirrer and heat it to 90°C in a water bath, and perform magnetic stirring , form HA-PVA primary emulsion, wherein, the PVA content is 20wt%, and the HA content is 5wt%.

[0034] 2) Preparation method of PLGA-HA-PVA primary emulsion: Weigh PLGA powder, add it to 5mL of dichloromethane, and continue ultrasonic vibration until PLGA is completely dissolved to form a homogeneous milky white primary emulsion; add the primary emulsion to the In the HA-PVA primary emulsion, heat to 90°C and continue magnetic stirring for 10 minutes, so that the dichloromethane is completely volatilized, and the PLGA-HA-PVA primary emulsion is prepared, wherein the PLGA content is 30wt%, the HA content is 5wt%, and the PVA content is 15wt%.

[0035] 3) Inject the HA-PVA primary emulsion ...

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Abstract

The invention discloses a method for preparing PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials. The method includes injecting HA-PVA primary emulsion into artificial cartilage molds I and carrying out freeze thawing on the HA-PVA primary emulsion to obtain pre-crosslink HA-PVA hydrogel; arranging the pre-crosslink HA-PVA hydrogen in the centers of artificial cartilage molds II slightly larger than the artificial cartilage molds I; injecting hot PLGA-HA-PVA primary emulsion into the artificial cartilage molds II and carrying out freeze thawing on the hot PLGA-HA-PVA primary emulsion. The method has the advantage that the novel gradient PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials prepared by the aid of the method are good in biocompatibility, and the biomechanical properties of the novel gradient PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage materials are similar to the biomechanical properties of cartilage.

Description

technical field [0001] The invention relates to a preparation method of artificial cartilage, in particular to a preparation method of PLGA-HA-PVA scaffold modified HA-PVA artificial cartilage material, belonging to the field of medical material preparation. Background technique [0002] Articular cartilage damage is a common clinical disease in orthopedics. At present, methods for repairing articular cartilage damage include allograft and allograft cartilage transplantation, microfracture technology, artificial joint replacement, tissue engineered cartilage and artificial cartilage materials. The source of donors for allogeneic cartilage transplantation is limited, while allogeneic cartilage transplantation has problems such as immune rejection between donors and recipients. In the past ten years, many scholars have reported that microfracture technology is effective in the treatment of cartilage defects, but there are also disadvantages such as slow repair process, cumber...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/26
CPCA61L27/26A61L27/50A61L2430/06C08L29/04C08L5/08C08L67/04
Inventor 胡懿郃苏伟平谢杰李明清曾敏汪龙
Owner 胡懿郃