A high-throughput analysis method for measuring volatile and semi-volatile components in particulate matters of cigarette main stream smoke

Abstract

The invention belongs to the technical field of particulate matter component analysis for cigarette main stream smoke, and particularly relates to a high-throughput analysis method for measuring volatile and semi-volatile components in particulate matters of cigarette main stream smoke. The method is characterized by comprising 1) a step of capturing the particulate matters of cigarette main stream smoke through a Cambridge filter, folding the Cambridge filter, transferring the filter into a sealed bottle, and adding an internal standard substance solution and an extracting solvent, 2) a step of performing ultrasonic extraction to obtain a smoke sample solution, and 3) a step of directly detecting the smoke sample solution by adopting GC / MS. The method adopts GC / MS analysis after the particulate matters captured by the Cambridge filter are directly extracted by utilizing the extracting solvent, can simultaneously detect 227 volatile and semi-volatile components in the cigarette main stream smoke, and has advantages of simple operation, rapid detection, low organic solvent using amounts, good repeatability, capability of avoiding concentration loss, and high throughput.

Description

technical field [0001] The invention belongs to the technical field of particle phase component detection of cigarette mainstream smoke, and in particular relates to a high-throughput analysis method for measuring volatile and semi-volatile components in cigarette mainstream smoke particulate matter. Background technique [0002] The composition of mainstream cigarette smoke is extremely complex. According to the latest statistics, 5,685 components have been identified in mainstream cigarette smoke [1]. Therefore, the analysis of cigarette mainstream smoke components has always been a big problem. In the past two decades, with the development of two-dimensional GC / MS technology, especially the development of comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS), a major breakthrough has been made in the qualitative analysis of cigarette smoke components. [2-4]. For example, Lu Xin et al. once collected 40 cigarette smoke particula...

AI Technical Summary

Problems solved by technology

Although GC×GC-TOFMS technology has greatly promoted the progress of qualitative analysis of particulate matter in mainstream cigarette smoke, GC×GC-TOFMS technology has some shortcomings, such as: 1) It is prone to false positives and false negatives Results; 2) A single compound is cut into two or more segments and transferred to a two-dimensional GC, resulting in multiple chromatographic peaks for a compound; 3) The operation of the instrument is complex, requiring skilled and professional operators, and the instrument is expensive, and conventional laboratories cannot be equipped

Therefore, GC×GC-TOFMS is difficult to be used in laboratory routine testing at present

[0003] Although there are many reports on the qualitative analysis of smoke particle phase components in literature research, the relevant literature on the quantitative analysis of compounds in smoke particle phase components basically focuses on polycyclic aromatic hydrocarbons, aromatic amines, phenol, nicotine, carbonyls, etc. In terms of harmful components, there are very few reports on the simultaneous determination of multiple indicators of volatile and semi-volatile components in flue gas, and the number of measured indicators is generally less than 100[5]

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