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A magnetic nanometer temperature measurement method based on odd harmonics of AC magnetization

A technology of magnetization intensity and odd harmonics, applied in diagnostic recording/measurement, medical science, diagnosis, etc., can solve problems such as difficulties in high-order harmonic measurement, achieve feasibility, improve measurement accuracy, and avoid harmonics Effect

Active Publication Date: 2019-07-12
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY +1
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Problems solved by technology

[0004] In order to solve the above technical problems, the present invention provides a magnetic nano temperature measurement method based on the odd harmonics of AC magnetization. Under the excitation of the mixed frequency magnetic field, the AC magnetization information of the magnetic nanoparticles contains rich odd harmonic information. , far more than the odd-order harmonic information of magnetic nanometers under a single-frequency alternating excitation magnetic field, which solves the difficult problem of high-order harmonic measurement, and can achieve high-precision temperature measurement, thereby meeting the accuracy of biological disease diagnosis and treatment Require

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  • A magnetic nanometer temperature measurement method based on odd harmonics of AC magnetization
  • A magnetic nanometer temperature measurement method based on odd harmonics of AC magnetization
  • A magnetic nanometer temperature measurement method based on odd harmonics of AC magnetization

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[0099] 1. Simulation model and test results

[0100] In order to study the effectiveness and superiority of the temperature measurement method based on the odd harmonic amplitude information of the magnetic nanoparticle magnetization response under the excitation of the mixed frequency magnetic field, this example conducts a simulation experiment with noise. The simulation experiments are divided into two groups: the first group is in the magnetic nano-Yangping effective magnetic moment M s =2*10^ -19 , Boltzmann constant K=1.38*10^ -23 , magnetic nano sample concentration (or solid particle number) N=2*10^ 19 Under the condition that the signal-to-noise ratio is 80dB, the single-frequency magnetic field strength is 60Gs, the frequency is 750Hz, the excitation frequency of the mixed-frequency alternating magnetic field is 750Hz, 5Hz, 0Hz, and the magnetic field strength is 60Gs, 6Gs, 6Gs respectively. The five temperature points of 320K, 330K, 340K, and 350K are continuousl...

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Abstract

The invention discloses a magnetic nanometer temperature measuring method based on odd harmonics of AC magnetization. The steps are as follows: placing a magnetic nanometer sample in an object area to be measured; The magnetic coil generates a mixed-frequency excitation magnetic field; a pair of differential detection coils is used to detect the magnetization signal of the magnetic nano-sample under the excitation of the mixed-frequency magnetic field; the amplitude of each odd harmonic signal of the magnetization signal of the magnetic nano-sample is extracted; The relationship between the odd harmonic amplitude and temperature is constructed, and the temperature inversion mathematical model is constructed, and the temperature inversion mathematical model is solved by an inversion algorithm to obtain temperature information. The present invention can measure more useful signals under the excitation of the frequency mixing magnetic field; utilize the relationship between rich harmonic information and temperature under the excitation of the frequency mixing magnetic field to construct an equation, avoid the difficult-to-measure harmonics, and improve the measurement accuracy; It is helpful to lay the foundation for studying the magnetic nanometer temperature imaging method under the excitation of mixing frequency.

Description

technical field [0001] The invention relates to the technical field of nanometer testing, in particular to a magnetic nanometer temperature measurement method based on odd harmonics of AC magnetization. Background technique [0002] Temperature is an important sign parameter of life activities. In the field of biomedicine, the temperature of vital signs can be used as an important parameter in the detection and treatment of biological diseases, such as real-time tissue / cell temperature information in tumor hyperthermia. The traditional method of measuring the temperature of internal tissues / cells of a living body uses a contact temperature sensor (thermocouple or thermal resistance) as a temperature sensitive element to measure the temperature. This measurement method requires opening the cavity of the living body, and implanting thermocouples or thermal resistors in key tissues, which brings trauma and treatment risks to the living body. When detecting the temperature of ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/01
CPCA61B5/01A61B5/7221A61B5/7235A61B5/7257
Inventor 杜中州甘勇刘文中苏日建皮仕强魏凯
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY