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Microelectrode array modified by platinum nanorod, and manufacturing method thereof

A microelectrode array, platinum nanotechnology, applied in electrodes, nanotechnology, head electrodes, etc., can solve the problems of surface modification limitation, poor mechanical stability, electrode surface falling off, etc.

Inactive Publication Date: 2016-11-16
SHENZHEN CAS-ENVISION MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Specifically, the methods for surface modification of microelectrode arrays are generally as follows: 1. A layer of platinum black (Anal. Chem. 1987, 59, 217-218) is modified on the surface of the electrode. At least an order of magnitude smaller, but its mechanical stability is very poor, and its modification layer contains toxic substances such as lead, making it unsuitable for applications in the biomedical field; ), this coating has good mechanical stability and is non-toxic, but its surface roughness is not large enough, so that its surface modification in ultra-high resolution electrodes is limited; 3. After iridium oxide (Eng.Med .Biol.Soc.2004,4153-4156) or conductive polymer (J.Biomed.Mater.Res.2001,56,261-272) modified microelectrode has excellent electrochemical performance (such as high charge injection ability), However, these materials have poor adhesion and can easily come off from the electrode surface during stimulation.

Method used

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  • Microelectrode array modified by platinum nanorod, and manufacturing method thereof
  • Microelectrode array modified by platinum nanorod, and manufacturing method thereof
  • Microelectrode array modified by platinum nanorod, and manufacturing method thereof

Examples

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Effect test

Embodiment 1

[0029] A method for preparing a platinum nanocolumn modified microelectrode array, comprising the following steps:

[0030] (1) At room temperature, add 1L of water and 1mmol of platinum chloride (PtCl 4 ) and 5mmol formic acid (HCOOH), shake and mix gently to form an electrodeposition solution;

[0031] (2) In the above-mentioned electrodeposition solution, put platinum sheet, Ag / AgCl reference electrode and micro-electrode, and connect with the electrochemical workstation, deposit at -0.1V (vsAg / AgCl) in the constant potential deposition method Next, electrodeposit for 300-600s to form a platinum nanocolumn modification layer on the surface of the microelectrode, that is, obtain a platinum nanocolumn modified microelectrode array.

[0032] figure 1 It is a scanning electron microscope (SEM) image of the platinum nanocolumn modification layer in this example. It can be seen from the figure that the obtained platinum nanocolumn has a uniform shape and a diameter of about 200...

Embodiment 2

[0034] A method for preparing a platinum nanocolumn modified microelectrode array, comprising the following steps:

[0035] (1) At room temperature, add 1 L of water and 1 mmol of platinum nitrate (Pt(NO 3 ) 4 ) and 10mmol formic acid (HCOOH), shake and mix gently to form an electrodeposition solution;

[0036] (2) In the above-mentioned electrodeposition solution, put platinum sheet, Ag / AgCl reference electrode and micro-electrode, and connect with the electrochemical workstation, deposit at -0.1V (vsAg / AgCl) in the constant potential deposition method Next, electrodeposit for 300-600s to form a platinum nanocolumn modification layer on the surface of the microelectrode, that is, obtain a platinum nanocolumn modified microelectrode array.

Embodiment 3

[0038] A method for preparing a platinum nanocolumn modified microelectrode array, comprising the following steps:

[0039] (1) At room temperature, add 1 L of water and 1 mmol of chloroplatinic acid (H 2 PtCl 6 ) and 20mmol hydroxylamine hydrochloride (NH 2 OH·HCl), gently shake and mix to form an electrodeposition solution;

[0040](2) In the above-mentioned electrodeposition solution, put platinum sheet, Ag / AgCl reference electrode and microelectrode, and connect with electrochemical work, deposit with constant current, under the condition of -0.3μA (vsAg / AgCl) Next, electrodeposit for 300-600s to form a platinum nanocolumn modification layer on the surface of the microelectrode, that is, obtain a platinum nanocolumn modified microelectrode array.

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Abstract

The invention provides a microelectrode array modified by platinum nanorods. The electrode surface of the microelectrode array is provided with a platinum nanorod modified layer. The microelectrode array uses the platinum nanorods as a surface modification layer. The binding force of the modification layer and a microelectrode substrate is relatively good, and the modification layer does not easily fall off, which causes the electrode to lose efficacy. Surface area of the modified microelectrode increases greatly, electrochemical impedance of the microelectrode obviously reduces, and electrode charge injection capacity and charge storage capacity increase greatly, being beneficial for reducing implanted system power consumption, and improving electrical stimulation effect. The modification layer has good biocompatibility, and applications of the microelectrode array in the field of biomedical field increase greatly. The invention also provides a manufacturing method for the microelectrode array modified by platinum nanorods.

Description

technical field [0001] The invention relates to the technical field of microelectrode surface modification, in particular to a platinum nanocolumn modified microelectrode array and a preparation method thereof. Background technique [0002] As one of the most important implantable microdevices, nerve stimulation / recording electrodes are used to stimulate nerve tissue or record nerve electrical signals (ECG, EEG, cortical electrical signals, etc.), and are widely used in brain-computer interface, neurophysiology, It is a very important research and diagnostic tool in life science fields such as brain science research. [0003] In order to reduce the trauma of implantation, provide more clinical stimulation modes and improve the resolution of electrical stimulation or recording, nerve stimulation electrodes / recording are developing in the direction of miniaturization and arraying—microelectrode arrays. However, the reduction in electrode size brings with it the problem of inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/042A61B5/0478A61B5/04A61N1/05C23C18/44C23C18/16B82Y30/00B82Y40/00
CPCA61B5/6847A61B2562/0209A61N1/05A61N1/0526A61N1/0551A61B5/24A61B5/283A61B5/291B82Y30/00B82Y40/00C23C18/1648C23C18/44
Inventor 夏凯吴天准孙滨曾齐彭琎
Owner SHENZHEN CAS-ENVISION MEDICAL TECH CO LTD