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Production method of degradable shape-memory polymer vascular scaffold

A vascular stent and polymer technology, applied in the fields of medical formula, medical science, prosthesis, etc., can solve the problems of vascular obstruction, poor processability and controllability, platelet aggregation, etc., and achieve the effect of promoting production

Inactive Publication Date: 2016-11-16
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high hardness of the metal stent, the processability and handling are poor, which limits its application
Moreover, defects such as platelet aggregation and vascular occlusion often occur after implantation, and patients can only take orally or inject anticoagulants for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of the vascular stent with the shape memory function of the bionic microstructure of the present invention is divided into the following steps:

[0023] Step 1: Preparation of shape memory polymer

[0024] Weigh an appropriate amount of 4arm PEG, ε-Cl, and SnCl2 and mix them into a single-neck bottle, wherein the mass ratio of 4arm PEG and ε-Cl is 1:2. Under the condition of magnetic stirring, vacuumize at room temperature for 5h, then at 140℃ After cooling down to room temperature, add an appropriate amount of dichloromethane to dissolve, pour a large amount of ice ethanol to stir and precipitate, then remove absolute ethanol by suction filtration and vacuum-dry to constant weight to obtain 4arm PEG-PCL. Add an appropriate amount of dichloromethane into a single-necked bottle, add 4arm PEG-PCL, acryloyl chloride, and triethylamine in sequence at a ratio of 1:1:1, mix and stir for 6 hours, remove part of the solvent by rotary evaporation, and add ice eth...

Embodiment 2

[0028] This example is basically the same as Example 1, except that in the first step of preparing the shape memory polymer, 4arm PEG and ε-Cl are weighed and reacted according to the mass ratio of 1:2.

Embodiment 3

[0030] This example is basically the same as Example 1, except that polyurethane is selected as the shape memory material in the first step of preparing the shape memory polymer.

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PUM

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Abstract

The invention discloses a production method of a degradable shape-memory polymer vascular scaffold. The production method includes: selecting a degradable shape-memory polymer material as the substrate material of the vascular scaffold; using the photoetching technology to produce a silicon wafer temperature with micro-patterns on the surface; pouring the shape-memory macromonomer material in the molten state onto the template, performing pre-polymerization monomer crosslinking under certain external stimulation to obtain a polymer piece with a shape-memory effect and with the micro-patterns on the surface, and curling the polymer substrate with the micro-patterns into a tubular shape so as to obtain the shape-memory polymer vascular scaffold with the induction bionic micro-patterns on the surface. The degradable shape-memory polymer vascular scaffold has the advantages that the degradable shape-memory polymer material is used to control cell growth through the patterned material, and accordingly a vascular structure is formed through bionic design, and angiogenesis is promoted.

Description

technical field [0001] The invention relates to biomaterials and functional macromolecules, in particular to a vascular tissue engineering scaffold that combines the surface microstructure regulation cell growth function with the shape memory polymer's shape memory function. Background technique [0002] Polycaprolactone (PCL), polyurethane (PU), polylactic acid (PLA) and other degradable shape memory materials are widely used in biomedicine because of their good shape memory performance, processing characteristics, biocompatibility and degradability. There are many applications in the field, such as tissue engineering scaffolds and drug controlled release carrier materials. At present, the research and application of cross-linked shape memory polymers is one of the research hotspots in the field of polymer synthesis and processing. Performance, higher activity and lower melt viscosity, so it has better processability. Shape memory polymers, as a new class of smart materia...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/58A61L27/18
CPCA61L27/18A61L27/50A61L27/507A61L27/58A61L2400/16C08L67/04C08L75/04
Inventor 周绍兵卢柳璇刘典龚韬赵坤
Owner SOUTHWEST JIAOTONG UNIV