Method for blood glucose and blood fat noninvasive nuclear magnetic resonance detection
A nuclear magnetic resonance and blood lipid technology, which is used in the analysis, application, and blood characterization device using nuclear magnetic resonance.
Active Publication Date: 2016-11-23
SOUTHEAST UNIV
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At the same time, clinical diagnosis shows that most diabetic patients are accompanied by abnormal blood lipids and eventually die of vascular diseases. Therefore, it is necessary to simultaneously detect blood sugar and blood lipids. The current non-invasive detection method of blood sugar can only reflect the index of blood sugar. The detection of blood lipids in blood cannot be realized at the same time
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[0021] The present invention will be described in further detail below in conjunction with the accompanying drawings.
[0022] Nuclear magnetic resonance technology is based on the electromagnetic induction signal generated by the spin resonance of the nucleus in an external magnetic field environment to realize the analysis of the composition and molecular structure of the substance. It is a non-destructive and non-contact detection. Protons have different dynamic characteristics in different chemical environments, resulting in different relaxation behaviors. NMR technology can identify substances based on this characteristic. There are a large number of hydrogen nuclei in the blood, and the concentration of blood sugar and blood lipids in the blood is different, and the chemical environment in which the hydrogen nuclei are located will also be different. Therefore, the simultaneous detection of blood glucose and blood lipids in blood can be realized in principle by using nuc...
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The invention relates to a method for blood glucose and blood fat noninvasive nuclear magnetic resonance detection. The method is achieved through a blood glucose and blood fat noninvasive nuclear magnetic resonance detection module and a blood glucose and blood fat minimally-invasive nuclear magnetic resonance precise detection module. The noninvasive module is used for directly carrying out nuclear magnetic resonance detection on the human body, and the minimally-invasive module is used for carrying out minimally-invasive blood sampling on the human body. The blood glucose and blood fat change situation, measured through blood glucose and blood fat noninvasive detection, of the same individual in different time periods is a blood glucose and blood fat relative value. The blood glucose and blood fat measured through blood glucose and blood fat minimally-invasive precise detection is an absolute value, and measurement results can serve as initial calibration of noninvasive measurement or calibration in the noninvasive detection process.
Description
technical field [0001] The invention relates to a method for non-invasive nuclear magnetic resonance detection of blood sugar and blood lipid. Background technique [0002] Diabetes is a metabolic disorder, characterized clinically by hyperglycemia. Therefore, the concentration of blood glucose in the blood is the main basis for judging diabetes. At present, the common method of clinical blood glucose detection is blood biochemical analysis after needle puncture or finger pricking blood. The biochemical analysis method of blood sugar has the characteristics of high accuracy, but because diabetic patients generally need to measure the blood sugar level at least 3 times a day during the diagnosis and treatment process. Frequent invasive blood analysis not only consumes a lot of reagents, but also greatly increases the physical and psychological burden of patients, and there is also a risk of infection. Therefore, it is of great social value and economic significance to study...
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IPC IPC(8): G01N24/08A61B5/145
CPCA61B5/14532A61B5/14546G01N24/08
Inventor 陆荣生易红倪中华尹奇峰姜晓文
Owner SOUTHEAST UNIV