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A kind of clathrate and preparation method thereof

A technology of scutellarin and inclusion compound, which is applied in the directions of active ingredients of hydroxy compounds, pharmaceutical formulations, drug combinations, etc., can solve the problems of instability of scutellarin aqueous injection, difficulty in making aqueous injection, etc., and achieves stable and feasible process. Effect

Active Publication Date: 2019-07-23
山东和美欣动物药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention provides a clathrate and preparation method thereof, so as to solve the problems of unstable and difficult making aqueous injections of existing winterin aqueous injections; and, in the preparation process of the present invention, no Antioxidant, there is no problem of safety in use

Method used

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  • A kind of clathrate and preparation method thereof
  • A kind of clathrate and preparation method thereof
  • A kind of clathrate and preparation method thereof

Examples

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Effect test

Embodiment 1

[0039] The preparation method of the clathrate of the present invention is as follows:

[0040] Weigh 5mg of PA and 90mg of β-CD and put them in a beaker, add 10ml of 50% ethanol to dissolve them, put them on a magnetic heating stirrer, and set the speed at 800r min at 30°C -1 , stirred for 2h, and stood at room temperature. The solution was evaporated under reduced pressure to remove ethanol, filtered through a 0.45 μm microporous membrane to remove unincluded PA, and the filtrate was vacuum-dried at 30° C. to obtain PA-β-CD.

[0041] Three batches of samples were prepared in parallel with the above process, and the content of PA was determined according to the content determination method. The inclusion rates of the three PA-β-CD were: 64.65%, 63.96%, and 63.72%, and the average inclusion rate was 64.11%. The RSD is 0.75%, indicating that the process is stable and feasible.

[0042] The obtained PA-β-CD was dissolved in purified water to obtain a water-injection of luteoli...

Embodiment 2

[0065] The preparation method of the clathrate of the present invention is as follows:

[0066] Weigh 5mg of PA and 135mg of β-CD respectively, put them in a beaker, add 10ml of 80% ethanol to dissolve them, put them on a magnetic heating stirrer, and set the fixed speed at 1200r·min at 20°C -1 , stirred for 3h, and stood at room temperature. The solution was evaporated under reduced pressure to remove ethanol, filtered through a 0.45 μm microporous membrane to remove unincluded PA, and the filtrate was vacuum-dried (30° C.) to obtain PA-β-CD.

[0067] The obtained PA-β-CD was dissolved in purified water to obtain a water-injection of luteolin.

Embodiment 3

[0069] The preparation method of the clathrate of the present invention is as follows:

[0070] Weigh 5mg of PA and 45mg of β-CD respectively, put them in a beaker, add 10ml of 50% ethanol to dissolve them, put them on a magnetic heating stirrer, and set the speed at 800r min at 50°C -1 , stirred for 0.5h, and stood at room temperature. The solution was evaporated under reduced pressure to remove ethanol, filtered through a 0.45 μm microporous membrane to remove unincluded PA, and the filtrate was vacuum-dried (30° C.) to obtain PA-β-CD.

[0071] The obtained PA-β-CD was dissolved in purified water to obtain a water-injection of luteolin.

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Abstract

The invention provides a method for preparing a wintergreen inclusion compound. The method comprises the step of causing wintergreen to be subjected to inclusion by beta-cyclodextrin to obtain the wintergreen inclusion compound. The invention further provides the wintergreen inclusion compound prepared through the method. The wintergreen inclusion compound obtained by application of the method has good stability and is high in content and inclusion rate. The inclusion rates of three parts are 64.65%, 63.96% and 63.72% respectively, the average of the inclusion rates is 64.11%, RSD is 0.75%, and it is indicated that the method is stable and feasible in process. A wintergreen injection prepared by applying the method has good stability, the content slightly descends within 6 months under the conditions of acceleration, but the appearance characteristics, the pH and clarity have no obvious change, the acceleration conditions are 40+ / -2 DEG C, and the relative humidity is 75+ / -5%.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a clathrate and a preparation method thereof. Background technique [0002] Wintergreen (also known as wintergrass, English abbreviation PA) is a commonly used traditional Chinese medicine. It is the dried whole plant of wintergreen (P.decorata H. Andres) or common wintergreen (Pyroladecorata H. Andres). , has the functions of dispelling rheumatism, strengthening muscles and bones, and stopping bleeding; it is used for rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough and overworked cough, recorded in the 2000 edition of the Chinese Pharmacopoeia. Since 1990, the Lanzhou Institute of Animal Husbandry and Veterinary Medicine of the Chinese Academy of Agricultural Sciences has carried out research on the chemical synthesis and clinical application of veterinary, so that the total yield of product synthesis has reached 60%. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K31/05A61K9/08A61P15/14A61P1/12A61P31/04
CPCA61K9/0019A61K9/08A61K31/05
Inventor 梁剑平陶蕾尚若锋赵凤舞王学红贾忠郝宝成刘宇郭文柱郭志廷
Owner 山东和美欣动物药业有限公司
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