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Effective part of Comarum salesovianum for resisting HIV-1 virus as well as preparation method and application thereof

An effective part, HIV-1 technology, applied in the field of plant extracts, can solve the problems of limited efficacy of AIDS drugs, achieve the effect of expanding usage, enhancing cytotoxicity, and expanding raw material channels

Active Publication Date: 2016-12-14
QINGHAI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing anti-HIV drugs Like other types of anti-HIV drugs, the efficacy of marketed AIDS drugs is limited as HIV-1 reverse transcriptase develops resistance mutations

Method used

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  • Effective part of Comarum salesovianum for resisting HIV-1 virus as well as preparation method and application thereof
  • Effective part of Comarum salesovianum for resisting HIV-1 virus as well as preparation method and application thereof
  • Effective part of Comarum salesovianum for resisting HIV-1 virus as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiments 1 to 3 are specific implementations of the anti-HIV-1 virus effective parts and preparation methods of Potentilla chinensis in Northwest China of the present invention, wherein embodiment 1 is the best embodiment.

[0031] Example 1

[0032] The preparation method comprises the following steps: pulverize the Northwest Potentilla chinensis, use an ethanol solution with a volume percentage concentration of 75% to 85% for ultrasonic extraction for 1 to 2 hours, filter to obtain an ultrasonic extraction solution and filter residue, and add the filter residue with a mass percentage concentration of 75% to 85%. 85% ethanol solution was refluxed and extracted 3 times, each time for 0.5 to 1 hour, to obtain a refluxed extract, combined the sonicated extract and the refluxed extract, concentrated and dried to obtain an extract; the extract was dispersed with distilled water to obtain an extract dispersion, and then Sequentially use petroleum ether, ethyl acetate and ...

Embodiment 2

[0034] The preparation method comprises the following steps: pulverize the Northwest Potentilla chinensis, use an ethanol solution with a volume percentage concentration of 85% to 95% for ultrasonic extraction for 2 to 3 hours, and filter to obtain an ultrasonic extraction solution and a filter residue, and add the filter residue with a mass percentage concentration of 85% to 95%. Reflux extraction with 95% ethanol solution twice, each time for 1.5 to 2 hours, to obtain a reflux extract, combine the sonic extract and reflux extract, concentrate and dry to obtain an extract; disperse the extract with distilled water to obtain an extract dispersion, and then Sequentially use petroleum ether, ethyl acetate and n-butanol as solvents to extract the extract dispersion, and evaporate the n-butanol from the obtained n-butanol extract to obtain the n-butanol part of Potentilla chinensis; extract the remaining extract after extraction The dispersion liquid was concentrated and dried to o...

Embodiment 3

[0036] The preparation method comprises the following steps: pulverize the Northwest Potentilla chinensis, use an ethanol solution with a volume percentage concentration of 65% to 75% for ultrasonic extraction for 0.5 to 1 hour, and filter to obtain the ultrasonic extraction solution and filter residue, and add the filter residue with a mass percentage concentration of 75% to 75%. 85% ethanol solution was refluxed and extracted 3 times, each time for 1 to 1.5 hours, to obtain a refluxed extract, combined with the ultrasonic extraction and refluxed extract, concentrated and dried to obtain an extract; the extract was dispersed with distilled water to obtain an extract dispersion, and then Sequentially use petroleum ether, ethyl acetate and n-butanol as solvents to extract the extract dispersion, and evaporate the n-butanol from the obtained n-butanol extract to obtain the n-butanol part of Potentilla chinensis; extract the remaining extract after extraction The dispersion liquid...

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Abstract

The invention provides an effective part of Comarum salesovianum for resisting HIV-1 virus as well as a preparation method and an application thereof, and belongs to the technical field of plant extracts. The effective part is n-butyl alcohol extract of Comarum salesovianum or a water phase extraction part Comarum salesovianum. Comarum salesovianum is crushed, an ethanol solution whose volume percentage concentration is 65-95% is added for extraction, and obtained extract is condensed and dried, in order to obtain an extract; the extract is dispersed in distilled water in order to obtain dispersion liquid of the extract, petroleum ether, ethyl acetate and n-butyl alcohol are used as solvents in order for extracting the dispersion liquid of the extract, solvents in the obtained n-butyl alcohol extract are volatilized, in order to obtain the n-butyl alcohol extract of Comarum salesovianum; after extraction, residual dispersion liquid of the extract is condensed and dried, and the water phase extraction part Comarum salesovianum. The invention provides the application of the effective part of Comarum salesovianum for resisting HIV-1 virus to preparation of medicaments for resisting HIV-1 virus, and the effective part is suitable for developing new drugs for resisting HIV-1 virus.

Description

technical field [0001] The anti-HIV-1 virus effective parts, preparation method and application of Northwest Potentilla chinensis belong to the technical field of plant extracts. Background technique [0002] Comarum salesovianum (Stepn.) Asch. et Gr. is a perennial subshrub plant of the genus Comarum palustre L. in the family Rosaceae [see: Editorial Committee of Flora of China, Chinese Academy of Sciences. Chinese higher plants [M]. Beijing: Science Press, 2003 (6).], is a traditional medicinal plant. It is mainly born in forest margins, under forests and wet grasslands of river valleys at an altitude of 2800-4250 meters. Distributed in the southwest, northwest, north and northeast of China. It is widely distributed in the northern temperate zone, and it is also found in North America, Europe to Japan, Asia Minor to the Himalayas, etc. .]. The Mongolian Academy of Sciences found that it has significant anti-inflammatory activity [see: Odontuya G, Banzragchgarav O, Mura...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P31/18
CPCA61K36/73A61K2236/333A61K2236/39A61K2236/53
Inventor 林鹏程胡秦高世宝
Owner QINGHAI UNIV FOR NATITIES
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