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Mubing dripping pills for treating acute myocardial ischemia and preparation method thereof

A technology of acute myocardial ischemia and dripping pills, which is applied in cardiovascular system diseases, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of low bioavailability, achieve broad market prospects, improve bioavailability, The effect of promoting intestinal permeability

Inactive Publication Date: 2017-01-04
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Existing studies have shown that the low bioavailability of vitexin-2"-O-rhamnoside after oral administration is mainly caused by the severe intestinal first-pass effect

Method used

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  • Mubing dripping pills for treating acute myocardial ischemia and preparation method thereof
  • Mubing dripping pills for treating acute myocardial ischemia and preparation method thereof
  • Mubing dripping pills for treating acute myocardial ischemia and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] The present embodiment provides a Mubing drop pill for the treatment of acute myocardial ischemia, which consists of vitexin-2"-O-rhamnoside, borneol, and drop pill matrix; the vitexin-2"-O-rhamnoside The weight and number ratio of noroside and borneol is 4:3; the weight and number ratio of the dropping pill base and vitexin-2"-O-rhamnoside is 5:1, and the dropping pill base is PEG6000.

[0029] The vitexin-2"-O-rhamnoside is a monomer compound extracted and separated from hawthorn leaves. The separation and purification process is as follows: (1) Extraction of chemical components: take 30 kg of hawthorn leaves, crush them, and place In the extraction container, heat and reflux extraction with 70% ethanol twice, the first time is 12 times the amount of 70% ethanol extraction for 1.5 hours, the second time is 10 times the amount of 70% ethanol extraction for 1 hour, filter and combine the extracts, Recover ethanol under reduced pressure until there is no alcohol smell, a...

Embodiment 2

[0076] The present embodiment provides a Mubing drop pill for the treatment of acute myocardial ischemia, which consists of vitexin-2"-O-rhamnoside, borneol, and drop pill matrix; the vitexin-2"-O-rhamnoside The weight and number ratio of noroside and borneol is 4:3; the weight and number ratio of the dropping pill matrix and vitexin-2"-O-rhamnoside is 6:1, and the dropping pill matrix is ​​PEG4000.

[0077] This embodiment also provides a preparation method of Mubing Dropping Pills for treating acute myocardial ischemia, which includes the following steps.

[0078] Step 1. Weigh vitexin-2"-O-rhamnoside and borneol according to the formula ratio, and add them into molten PEG4000 to obtain a mixed solution.

[0079] Step 2. Continue heating and stirring the mixed solution to make a uniform molten medicinal solution.

[0080] Step 3. Transfer the molten medicinal liquid to the liquid storage bottle, adjust the temperature control system of the dripping pill machine, and pass the ...

Embodiment 3

[0083] The present embodiment provides a Mubing drop pill for the treatment of acute myocardial ischemia, which consists of vitexin-2"-O-rhamnoside, borneol, and drop pill matrix; the vitexin-2"-O-rhamnoside The ratio of parts by weight of noroside and Borneoside is 4:3; the ratio of parts by weight of the dropping pill base and vitexin-2"-O-rhamnoside is 7:1, and the base of dropping pills is composed of PEG4000 and Composed of PEG6000, the ratio of parts by weight of PEG4000 to PEG6000 is 1:1.

[0084] This embodiment also provides a preparation method of Mubing Dropping Pills for treating acute myocardial ischemia, which includes the following steps.

[0085] Step 1. Weigh vitexin-2"-O-rhamnoside and borneol according to the formula ratio, and add them to molten PEG4000 and PEG6000 to obtain a mixed solution.

[0086] Step 2. Continue heating and stirring the mixed solution to make a uniform molten medicinal solution.

[0087] Step 3. Transfer the molten medicinal liquid ...

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Abstract

Mubing dripping pills for treating acute myocardial ischemia are composed of vitexin-2'-O-rhamnoside, borneol and a dripping pill matrix; each pill of the Mubing dripping pills contains 1-10 mg of vitexin-2'-O-rhamnoside and 1-5 mg of borneol; the vitexin-2'-O-rhamnoside is a monomer compound extracted and separated from crataegus pinnatifida leaves. The invention also provides a preparation method of the Mubing dripping pills for treating acute myocardial ischemia; the crataegus pinnatifida leaf active monomer composition vitexin-2'-O-rhamnoside and the borneol are selected for combined drug use to prepare the dripping pills; the borneol as an absorption enhancer has the effect of promoting intestinal permeability, and can significantly improve the bioavailability of the vitexin-2'-O-rhamnoside. The Mubing dripping pills can be sublingually administrated, are quick in absorption and low in dosage, can accurately adjust the drug dosage through increasing or decreasing the number of the pills in clinical medication, are easy to carry, are used as a new drug of natural product developed traditional Chinese medicines, and have broad market prospects.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to Mubing dripping pills for treating acute myocardial ischemia and a preparation method thereof. Background technique [0002] With the development of society and economy, profound changes have taken place in the national lifestyle, especially the aging of the population and the acceleration of urbanization. The prevalence of risk factors for cardiovascular disease in China is obvious, leading to a continuous increase in the number of cardiovascular diseases. In the next ten years, the number of patients with cardiovascular diseases will continue to increase rapidly, and the death of cardiovascular diseases will account for the first cause of death among urban and rural residents. The disease burden of cardiovascular diseases will increase day by day, and it has become a major public health problem. Myocardial ischemia refers to a pathological state in which the blood p...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K47/10A61K9/20A61P9/10A61K31/045
Inventor 英锡相英哲铭张文洁高瑜聪
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE