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Traditional Chinese medicine composition for treating gingivitis, aquogel film agent directly bonded to gingiva, aquogel film and its preparation method

A composition and technology for gingivitis, applied in the field of traditional Chinese medicine preparations, can solve the problems of diversity of gingivitis strains, destruction of beneficial oral bacteria by drug-resistant strains, poor chemical treatment effect of antibiotics, etc., to achieve retention of active ingredients, strict compatibility, low resistance Effects of ionicity and shear resistance

Inactive Publication Date: 2017-01-04
广州市育才中学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical treatments such as antibiotics are less effective due to the diversity of gingivitis-causing strains, drug-resistant strains, and destruction of beneficial oral bacteria

Method used

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  • Traditional Chinese medicine composition for treating gingivitis, aquogel film agent directly bonded to gingiva, aquogel film and its preparation method
  • Traditional Chinese medicine composition for treating gingivitis, aquogel film agent directly bonded to gingiva, aquogel film and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Angelica sinensis 100g, crushed properly, added 8 times the amount of purified water, namely 800mL, and extracted with a volatile oil extractor for 4 hours to obtain angelica sinensis volatile oil with an extraction rate of 0.52%. Angelica dregs, 300g rhubarb, 300g rhubarb, 500g astragalus, 100g Burnet plus 8 times of water, extract twice, 1 hour each time, then filter through 8 layers of gauze, and depressurize the filtrate at 60°C and 0.75-0.85MPa Concentrate to a thick paste with a relative density of 1.2-1.3. At room temperature of 20°C, add 0.52 g of volatile oil of Angelica sinensis, 2.5 g of paeonol, and 2.5 g of total alkaloids of Sophora sophorae into the thick paste, and stir evenly to obtain the total extract, which is a traditional Chinese medicine composition for treating gingivitis.

Embodiment 2

[0054] Angelica sinensis 100g, crushed properly, added 6 times the amount of purified water, namely 600mL, extracted with a volatile oil extractor for 3 hours to obtain angelica sinensis volatile oil with an extraction rate of 0.50%. Angelica dregs, Coptidis 200g, Rhubarb 200g, Astragalus 600g, Burnet 150g plus 6 times of water, extract 3 times, each time for 1 hour, then filter with 8 layers of gauze, and depressurize the filtrate at 60°C and 0.75-0.85MPa Concentrate to a thick paste with a relative density of 1.2-1.3. At room temperature of 25°C, add 0.50 g of volatile oil of angelica sinensis, 5 g of paeonol, and 5 g of total alkaloids of Sophora sophorae into the thick paste, and stir evenly to obtain the total extract, which is a traditional Chinese medicine composition for treating gingivitis.

Embodiment 3

[0056] 100g of Angelica sinensis was properly pulverized, added 7 times the amount of purified water, namely 700mL, and extracted with a volatile oil extractor for 3.5 hours to obtain Angelica sinensis volatile oil with an extraction rate of 0.55%. Angelica dregs, 400g rhubarb, 400g rhubarb, 700g astragalus, 100g Burnet plus 8 times of water, extract twice for 1.5 hours each time, then filter through 8 layers of gauze, and depressurize the filtrate at 60°C and 0.75-0.85MPa Concentrate to a thick paste with a relative density of 1.2-1.3. At room temperature of 20°C, add 0.55 g of volatile oil of Angelica sinensis, 4 g of paeonol, and 4 g of total alkaloids of Sophora sophorae into the thick paste, and stir evenly to obtain the total extract, which is a traditional Chinese medicine composition for treating gingivitis.

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Abstract

The invention refers to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating gingivitis, an aquogel film agent directly bonded to gingiva, an aquogel film and its preparation method, wherein the traditional Chinese medicine composition is prepared by 5-10 parts of coptis chinensis, 5-10 parts of rheum officinale, 10-20 parts of astragalus membranaceus, 2-4 parts of angelica sinensis, 2-6 parts of sanguisorba officinalis, 0.1-0.5 part of paeonol and 0.1-0.5 part of sophora alopecuroide total alkaloid extract; the composition has good total alkaloid and antibacterial actions for treating gingivitis; the aquogel film prepared by the traditional Chinese medicine composition applies the gingiva-imitated sawtooth design; when the film is in use, the tooth part of the sawtooth is just aligned to the convex part of gingiva, thus the drug part in the aquogel film is sufficiently contacted with the inflamed gingiva part to display the targeted anti-inflammatory effect; moreover, the film is strong in stickiness and not easy to drop off.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating gingivitis, a hydrogel film directly adhered to the gums, a hydrogel film and a preparation method thereof. Background technique [0002] Gingivitis (Gingivitis) refers to an inflammatory disease that is mainly caused by the accumulation of bacterial plaque in the gum tissue without invading other deep periodontal tissues, with red and swollen gums, free gums or gingival papilla changing from pink to dark red or dark red, gingival margins Thickened, no longer close to the tooth surface, gingival papilla becomes round and blunt hypertrophy, gingival bleeding when light touch or probing, tenderness, increased gingival crevicular fluid exudation, soft and fragile gingiva, lack of elasticity, gingival sulcus can be deepened More than 2mm, the formation of false periodontal pockets and other symp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/739A61K9/70A61P1/02A61K31/12
CPCA61K36/718A61K9/006A61K31/12A61K36/232A61K36/481A61K36/489A61K36/708A61K36/739A61K47/10A61K47/32A61K47/38A61K2236/331A61K2236/39
Inventor 赵祖逸
Owner 广州市育才中学