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A kind of gold/quaternary carbon dot core-shell nanocomposite material and preparation method thereof

A composite material, quaternary carbon dot technology, applied in the direction of wave energy or particle radiation treatment materials, pharmaceutical formulations, drug combinations, etc., can solve the problems of uneven thermal field distribution, low heating efficiency, implanted heat sources, etc., and achieve low toxicity Good, good effect, the effect of reducing pollution

Active Publication Date: 2019-12-10
TANGSHAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these heating methods have disadvantages such as uneven thermal field distribution and low heating efficiency, and some methods even require surgical implantation of heat sources

Method used

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  • A kind of gold/quaternary carbon dot core-shell nanocomposite material and preparation method thereof
  • A kind of gold/quaternary carbon dot core-shell nanocomposite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of quaternary carbon dots:

[0022] Weigh 1g of betaine hydrochloride and dissolve it in 20mL of deionized water, then add trishydroxymethylaminomethane with a molar ratio of 1:1, after it is completely dissolved, add excess isopropanol, and the obtained slurry is at 70 o C under vacuum for 36 h. After drying, the viscous white substance is muffle furnace 250 o After heating at C for 2 hours, 0.8 g of a brown solid was obtained, which was added to 50 mL of deionized water. The amount of deionized water used here was 50-100 times the weight of the brown solid, and the resulting brown dispersion was precipitated with 65 mL of acetone. , the ratio of acetone to deionized water in the brown dispersion is 1:1-2:1, and the dark brown powder can be obtained by drying at room temperature, that is, quaternary carbon dots.

[0023] (2) Preparation of gold nanoparticles:

[0024] Weigh 2 g of safflower gum and add it to 20 mL of deionized water, centrifuge at a ...

Embodiment 2

[0028] (1) Preparation of quaternary carbon dots:

[0029] Weigh 1.5g of betaine hydrochloride and dissolve it in 30mL of deionized water, then add trishydroxymethylaminomethane with a molar ratio of 1:1, after it is completely dissolved, add excess isopropanol, and the obtained slurry is at 65 o C under vacuum for 48h. After drying, the viscous white substance is muffle furnace 250 o After heating at C for 2 hours, 1.2 g of a brown solid was obtained, which was added to 100 mL of deionized water. The amount of deionized water used here was 50-100 times the weight of the brown solid, and the resulting brown dispersion was precipitated with 150 mL of acetone. , the ratio of acetone to deionized water in the brown dispersion is 1:1-2:1, and the dark brown powder can be obtained by drying at room temperature, that is, quaternary carbon dots.

[0030] (2) Preparation of gold nanoparticles:

[0031] Weigh 2.5g of safflower gum and add it to 30mL of deionized water, centrifuge at...

Embodiment 3

[0035] (1) Preparation of quaternary carbon dots:

[0036] Weigh 2g of betaine hydrochloride and dissolve it in 40mL of deionized water, then add trishydroxymethylaminomethane with a molar ratio of 1:1, after it is completely dissolved, add excess isopropanol, and the obtained slurry is at 70 o C under vacuum for 48h. After drying, the viscous white substance is muffle furnace 250 o 1.4 g of brown solid was obtained after heating at C for 2 hours, which was added to 90 mL of deionized water. The amount of deionized water used here was 50-100 times that of the brown solid weight, and the brown dispersion formed was precipitated with 120 mL of acetone. The ratio of acetone to deionized water in the brown dispersion is 1:1-2:1, and the dark brown powder can be obtained by drying at room temperature, that is, quaternary carbon dots.

[0037] (2) Preparation of gold nanoparticles:

[0038] Weigh 2.2g safflower gum and add it to 35mL deionized water, centrifuge at a speed of 1000...

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Abstract

A gold / quaternary carbon dot core-shell nanocomposite material and a preparation method thereof. The composite material uses gold nanoparticles as the core and quaternary carbon dots as the shell; the method is: dissolve betaine hydrochloride in deionized water, add trishydroxymethylaminomethane, add isopropanol after dissolving, and vacuum the obtained slurry Drying; after drying, add the brown solid obtained by heating in a muffle furnace into deionized water, and precipitate the formed brown dispersion with acetone, and dry at room temperature to obtain quaternary carbon spots; Add chloroauric acid solution to the liquid part, stir magnetically to obtain gold nanosol; dissolve quaternary carbon dots in deionized water, add gold nanosol, and ultrasonically disperse in a probe ultrasonic breaker to obtain a composite material. The material has near-infrared absorption function, stable fluorescence, monodispersity of particle size, low toxicity and good biocompatibility, and realizes the treatment and real-time morphology monitoring of cancer cells in living organisms. Application prospect.

Description

technical field [0001] The invention belongs to the field of nanocomposite materials, and relates to a core-shell nanocomposite material, in particular to a gold / quaternary carbon dot core-shell nanocomposite material and a preparation method thereof. Background technique [0002] Malignant tumor (cancer) is one of the major diseases that seriously threaten human life in today's society. Due to the low sensitivity and specificity of conventional diagnostic methods for cancer, it is difficult to detect cancer cells in the early stages of their appearance. Therefore, once many patients are found to be infected by cancer cells, most of them are in the middle and advanced stages, and have missed the best period of cure. In addition, chemotherapy is one of the main means of treating tumor diseases at present, but it is a systemic treatment method. While killing tumor cells, it also kills normal cells and immune cells together. "Therapeutic method. In recent years, hyperthermia ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/00A61P35/00
CPCA61K41/0052A61K49/0065A61K49/0093
Inventor 张青
Owner TANGSHAN NORMAL UNIV