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A kind of extracting and refining method of cinnamon twig volatile oil

A refining method and volatile oil technology, applied in the field of medicine, can solve the problem of low cinnamic aldehyde content in cinnamon twig volatile oil, and achieve the effects of simple operation, cost reduction and time shortening

Active Publication Date: 2019-11-01
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the cinnamon stick volatile oil that adopts this extraction method to obtain also has the problem that cinnamaldehyde content is low

Method used

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  • A kind of extracting and refining method of cinnamon twig volatile oil
  • A kind of extracting and refining method of cinnamon twig volatile oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 200kg of cassia twig decoction pieces, and extract the volatile oil directly through the steam. The extraction time is 2h. During the extraction process, add 2L of ethyl acetate to the volatile oil separator, and add it in 6 times (frequency 3 times / h), so that the volatile oil is dissolved in the ethyl acetate. layer, complete the extraction, separate and combine the ethyl acetate layer; the ethyl acetate layer was recovered under reduced pressure at a temperature of 50°C and a vacuum of -0.03Mpa until no obvious fractions flowed out to obtain 641mL of crude cinnamon twig volatile oil; 641mL of 95% ethanol was recovered under reduced pressure until no obvious fraction flowed out to obtain 635mL of cinnamon twig volatile oil, and the extraction rate of cinnamon twig volatile oil was 90.71%. Detected by GC, the cinnamon aldehyde content is 92.1%, and the residual ethyl acetate is 31ppm (see Figure 1-2 ).

Embodiment 2

[0044] Take 200kg of cassia twig decoction pieces, and extract the volatile oil directly through the steam. The extraction time is 3h. During the extraction process, add 6L of ethyl acetate to the volatile oil separator, and add it in 6 times (frequency 2 times / h), so that the volatile oil is dissolved in the ethyl acetate. layer, complete the extraction, separate and combine the ethyl acetate layer; the ethyl acetate layer was recovered under reduced pressure at a temperature of 60°C and a vacuum of -0.05Mpa until no obvious fractions flowed out to obtain 660 mL of crude cinnamon twig volatile oil, and added 330mL of 98% ethanol was recovered under reduced pressure until no obvious fractions flowed out, and 657mL of cinnamon twig volatile oil was obtained, and the extraction rate of cinnamon twig volatile oil was 93.86%. Detected by GC, the content of cinnamic aldehyde was 92.7%, and the residual ethyl acetate was 34ppm.

Embodiment 3

[0046] Take 200kg of cassia twig decoction pieces, and extract the volatile oil directly through the steam. The extraction time is 4h. During the extraction process, add 8L of ethyl acetate to the volatile oil separator, and add it in 4 times (frequency 1 time / h), so that the volatile oil is dissolved in the ethyl acetate. layer, complete the extraction, separate and combine the ethyl acetate layer; the ethyl acetate layer was recovered under reduced pressure at a temperature of 80°C and a vacuum of -0.1Mpa until no obvious fractions flowed out to obtain 665mL of crude cinnamon twig volatile oil, which was added to 1330mL of 100% ethanol was recovered under reduced pressure until no obvious fraction flowed out to obtain 662mL of cinnamon twig volatile oil, and the extraction rate of cinnamon twig volatile oil was 94.57%. Detected by GC, the content of cinnamaldehyde was 95.1%, and the residual ethyl acetate was 14ppm.

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Abstract

The invention relates to the technical field of medicines, in particular to an extracting and refining method of cassia twig volatile oil. The extracting and refining method comprises the following steps: extracting volatile oil in cassia twig decoction pieces by a direct steam method; adding a first organic solvent in a volatile oil separating device in an extracting process so as to enable the volatile oil to be dissolved in the first organic solvent; leaching and separating to obtain an organic solvent layer; reducing pressure of the organic solvent layer to recycle the solvent so as to obtain a cassia twig volatile oil crude product; and refining the cassia twig volatile oil crude product to obtain the cassia twig volatile oil. By the extracting and refining method, extracting and leaching of the cassia twig volatile oil can be carried out simultaneously, the extracting rate of the cassia twig volatile oil and the content of cinnamaldehyde in the volatile oil are increased, residue of ethyl acetate is low, the extracting rate of the cassia twig volatile oil is above 90%, the content of the cinnamaldehyde in the refined cassia twig volatile oil is above 90%, and the residue of the ethyl acetate is lower than 35 ppm. The method for extracting the cassia twig volatile oil is high in efficiency, easy to operate, low in production cost and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for extracting and refining cinnamon twig volatile oil. Background technique [0002] Guizhi is the dry twig of Cirmarnomumcassia Presl, a plant in the Lauraceae family. Its nature and flavor are "pungent, sweet, and warm". For anemofrigid cold, epigastric cold pain, blood-cold amenorrhea, joint arthralgia, phlegm retention, edema, palpitation, galloping. [0003] The active ingredients of cassia twig are cinnamaldehyde, cinnamic acid, cinnamon alcohol, coumarin and protocatechuic acid. Pharmacological studies have shown that cinnamic acid has antibacterial and anti-inflammatory effects, and cinnamic aldehyde has obvious sedative and analgesic effects. In recent years, through the research and analysis of relevant scholars and experts, cassia twig contains higher volatile oil, and its main component in the volatile oil is cinnamaldehyde, which still contains benzaldeh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11B9/02
CPCC11B9/022C11B9/025
Inventor 萧伟王正宽刘圆李家春王振中胡晗绯
Owner JIANGSU KANION PHARMA CO LTD