Transdermal absorption preparation and method for preparing transdermal absorption preparation
A technology for preparations and pharmaceutical preparations, which can be used in antiviral agents, pharmaceutical formulations, medical preparations with non-active ingredients, etc., and can solve problems such as bad taste
Active Publication Date: 2021-03-26
SUNSHINE LAKE PHARM CO LTD
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
In addition, percutaneous absorption preparations can enhance the compliance of patients with medication, solve the problem of administration under special circumstances (such as under water shortage conditions, patients with dysphagia, infants and children), and avoid the bad taste caused by oral administration. Reduce adverse reactions caused by oral administration
Method used
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Embodiment Construction
[0017] It should be noted that the present invention is based on the inventor's following findings:
[0018] The existing oseltamivir preparations are basically oral preparations, and taste-masking agents are often used to cover the bitter taste of oseltamivir, but adding taste-masking agents to the preparations may not completely cover the taste of oseltamivir. bitterness. At the same time, oral medicines are limited to specific groups of people (the elderly, children and infants) or under specific conditions (patients with dehydration conditions and dysphagia). However, there is currently no percutaneous absorption formulation of oseltamivir on the market, and there is a lack of in-depth research on the percutaneous absorption formulation of oseltamivir in the prior art.
[0019] In order to conduct a feasibility study on the development of oseltamivir transdermal formulations and provide data support for the transdermal administration of oseltamivir, the inventors investig...
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Abstract
The invention discloses a transdermic absorption preparation containing oseltamivir or a pharmaceutically acceptable salt thereof. The transdermic absorption preparation comprises a backing layer, a protection layer and a medicinal preparation layer, and the medicinal preparation layer is positioned between the backing layer and the protection layer, and contains oseltamivir or the pharmaceutically acceptable salt thereof. The transdermic absorption preparation avoids digestive system untoward effects caused by oral administration; and the transdermic absorption preparation is convenient to administrate, and can improve the patients' compliance. A preparation method of the transdermic absorption preparation is simple and cheap, and is suitable for industrial production.
Description
technical field [0001] The invention relates to the field of medicine and chemical industry. Specifically, the present invention relates to transdermal absorption preparations and methods for preparing transdermal absorption preparations. Background technique [0002] Oseltamivir, the chemical name is (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)cyclohexene-1-carboxylic acid ethyl ester. The chemical structural formula is as follows: [0003] [0004] Oseltamivir has a strong neuraminidase inhibitory activity and is effective against influenza A and B viruses. Information on its properties and preparation methods are disclosed in WO 1998007685 A1 and WO 1996026933 A1. [0005] The dosage forms of oseltamivir currently on the market include granules, capsules, and dry suspensions. However, oseltamivir is a drug with a particularly bitter taste, so its oral pharmaceutical composition is difficult to swallow. In the prior art, the bitter taste of oseltamivir is usual...
Claims
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IPC IPC(8): A61K9/70A61K31/215A61K47/32A61P31/16
CPCA61K9/7061A61K31/215
Inventor 戴伟罗丽娜赵步文游劲松黄芳芳
Owner SUNSHINE LAKE PHARM CO LTD