Dipyridamole oral emulsion administration system and preparation method thereof

A technology of dipyridamole emulsion and pyridamole emulsion, which is applied in the fields of pharmaceutical formulations, respiratory diseases, urinary system diseases, etc., can solve problems such as difficulty in forming milky liquid, large particle size, etc., and achieve a reduction in gastrointestinal tract Adverse reactions, small particle size, uniform dosage effect

Active Publication Date: 2017-02-15
黑龙江童医生儿童生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is well known that it is difficult for emulsions to form stable emulsions under slight stirring or peristalsis of the gastrointestinal tract, and the particle size is large. The stability of emulsions is still a problem to be solved in the process.

Method used

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  • Dipyridamole oral emulsion administration system and preparation method thereof
  • Dipyridamole oral emulsion administration system and preparation method thereof
  • Dipyridamole oral emulsion administration system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of dipyridamole emulsion, is made up of the composition of following parts by weight:

[0039]

Embodiment 2

[0041] A kind of dipyridamole emulsion, is made up of the composition of following parts by weight:

[0042]

[0043]

Embodiment 3

[0045] A kind of dipyridamole emulsion, is made up of the composition of following parts by weight:

[0046]

[0047] The preparation method of described dipyridamole emulsion is as follows:

[0048] (1) Preparation of the oil phase: add dipyridamole, soybean lecithin, poloxamer, serine phospholipid and monoglyceride laurate to the camellia oil, stir well and place in a water bath to keep the temperature at 60°C;

[0049] (2) Preparation of the water phase: Add sodium oleate and sodium alginate to 125 parts of water, stir well and place in a water bath to keep the temperature at 70°C;

[0050] (3) Preparation of colostrum: place the water phase in a tissue masher, and stir for 5 minutes under the condition of 4000r / min; slowly add the oil phase into the water phase, and stir while adding, all After adding, continue to stir under the above conditions for 5 minutes; add 125 parts of water and continue to stir for 10 minutes to obtain colostrum;

[0051] (4) Preparation of e...

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Abstract

The invention provides a dipyridamole emulsion which comprises the following components in parts by weight: 1-2.5 parts of dipyridamole, 5-75 parts of emulsifier, 0.1-15 parts of a co-emulsifier, 25-150 parts of oil, 250-500 parts of water, 0.5-1 part of a sweetening agent, 1-2 parts of an aromatic and 0.25-0.5 part of a preservative. The dipyridamole emulsion provided by the invention has the advantages of uniform texture, good stability, improved drug dissolution, easiness in absorption by the human body and high bioavailability. After high-pressure homogenization, the particle size of the emulsion is small in uniform distribution, the emulsion has good stability, the dissolution of dipyridamole is remarkably improved, and the oral bioavailability is enhanced; and flavoring agents such as the sweetening agent and the aromatic also can be added into the emulsion, so that disagreeable tastes of the drug can be effectively covered, and multiple tastes provide multiple options for children. Through a sterilization process, a little or no preservative can be added, so that the quality of the finished product of the emulsion is improved, and the safety of pediatric drugs is further enhanced.

Description

technical field [0001] The invention belongs to the technical field of oral emulsions, in particular to a dipyridamole oral emulsion delivery system and a preparation method thereof. Background technique [0002] Dipyridamole, also known as dipyridamole, is used as a strong coronary artery expansion drug for acute and chronic coronary insufficiency and angina pectoris. It has antithrombotic effect, can inhibit platelet aggregation, and high concentration can inhibit platelet release. Dipyridamole has a strong expansion effect on coronary vessels, can significantly increase coronary flow, and increase myocardial blood supply. It has been successfully used clinically for the prevention and treatment of angina pectoris, the recurrence of myocardial infarction and thrombosis, etc. for a long time. In recent years, studies have found that dipyridamole has broad-spectrum antiviral activity, can inhibit the specific proliferation of viruses, and can also induce interferon to enhan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/519A61K47/44A61P9/10A61P7/02A61P31/14A61P31/20A61P31/22A61P13/12A61P37/08A61P11/06
CPCA61K9/107A61K31/519A61K47/44
Inventor 刘晓磊王世岭姜波王娜徐霜
Owner 黑龙江童医生儿童生物制药有限公司
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