Application of ICAM-1 or alphaMbeta2 integral protein in screening of medicine for diagnosing or treating implantation metastatic cancer
A technology of ICAM-1, 1.ICAM-1, applied in the field of biomedicine, can solve the problem of unclear survival mechanism of tumor cell spheroids
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[0034] 1. Materials and methods
[0035] 1.1 Study Approval
[0036] All animal experiments were performed with institutional approval from the Yale University Animal Care Committee. Human tumor spheroids from patients with advanced (ie, stage III-IV) ovarian cancer were collected from ascitic fluid provided by informed consenting patients as completed at Yale University School of Medicine, New Haven, CT (HIC protocol #1111003959). Clinical paraffin specimens were used after approval by the Ethics Review Committee of Cancer Hospital Affiliated to Harbin Medical University, China.
[0037] 1.2 Animal models
[0038] All animal experiments were performed with the approval of the Yale University Animal Care Committee. All mice were of the C57BL / 6 series. Lysozyme Cre mice were crossed with tomato (mT / mG) mice to extract cells with the lineage marker lysozyme. Nude mice were purchased from Jackson Laboratory. Cell culture medium was grown on 100 μl mouse ovarian cancer...
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