Application of polaprezinc in preparation of medicine for treating or alleviating alimentary tract complications and irritable bowel syndrome caused by chemoradiotherapy

A technology for irritable bowel syndrome and polyzinc, which is applied in the field of medicine and can solve problems such as the use of gastrointestinal damage that is not disclosed

Active Publication Date: 2017-03-08
吉林省博大伟业制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art does not disclose the use of polyprezinc to treat vomiting and digestive tract damage caused by radiotherapy and chemotherapy.

Method used

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  • Application of polaprezinc in preparation of medicine for treating or alleviating alimentary tract complications and irritable bowel syndrome caused by chemoradiotherapy
  • Application of polaprezinc in preparation of medicine for treating or alleviating alimentary tract complications and irritable bowel syndrome caused by chemoradiotherapy
  • Application of polaprezinc in preparation of medicine for treating or alleviating alimentary tract complications and irritable bowel syndrome caused by chemoradiotherapy

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A tablet, the weight of each ingredient needed to prepare 100 tablets is as follows:

[0044]

Embodiment 2

[0046] A tablet, the weight of each ingredient needed to prepare 100 tablets is as follows:

[0047]

[0048] The preparation method of described tablet comprises:

[0049] S1. Sodium hydroxymethyl cellulose and half of mannan were dissolved in distilled water with 10 times the mass to prepare a mixed solution;

[0050] S2. Mix polyprezinc, pregelatinized starch and the remaining amount of mannan evenly and pulverize to obtain microparticles with a particle size of 10 μm;

[0051] S3. Mix the mixed solution obtained in step S1 and the microparticles obtained in step S2 to make a soft material, pass through a 14-mesh sieve to granulate, and pass through a 14-mesh sieve after drying to obtain drug granules;

[0052] S4. Mix the drug granules obtained in step S3 with maltitol and sodium lactate evenly and place them in a tablet machine to prepare tablets.

Embodiment 3

[0054] A tablet, the weight of each ingredient needed to prepare 100 tablets is as follows:

[0055]

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Abstract

The invention provides application of polaprezinc in preparation of a medicine for treating or alleviating alimentary tract complications and irritable bowel syndromes caused by chemoradiotherapy. By the aid of the polaprezincr, rising of emesis-related neurotransmitters incluiding 5-hydroxy tryptamine and NF-kB in blood and brain tissues, which is caused by the chemoradiotherapy, can be lowered, stimulations and hurts to the alimentary tract from the chemoradiotherapy can be reduced, and related symptoms of 5-hydroxy tryptamine related irritable bowel syndromes can be alleviated; proved by clinical tests, the polaprezincr is capable of alleviating symptoms of emesis and alimentary injuries of a patient effectively and is remarkably effective in treatment of 5-hydroxy tryptamine related irritable bowel syndromes.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of polyprezinc in the preparation of medicines for treating or alleviating digestive tract complications and irritable bowel syndrome caused by radiotherapy and chemotherapy. Background technique [0002] Chemoradiotherapy is the main means of treating tumors. Chemoradiotherapy kills tumor cells and often causes nausea, vomiting, damage to gastric mucosa and other discomfort symptoms in patients, which reduces the quality of life of patients, hinders the smooth progress of tumor treatment, and easily leads to some Related complications, such as malnutrition, metabolic disorders, dehydration, gastrointestinal bleeding, etc. [0003] Polyprezinc is a chelate of zinc and L-carnosine. L-carnosine is an ideal transporter of zinc, which can increase the absorption and metabolism of zinc in the body. It has anti-inflammatory and anti-oxidative functions. It i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/555A61P1/00A61P1/08A61K9/20A61K9/16
CPCA61K9/1652A61K9/2054A61K9/2059A61K38/05A61P1/00
Inventor 刘朝阳谢文博李明如腾楠
Owner 吉林省博大伟业制药有限公司
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