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A core-shell structure zinc oxide clay antidiarrheal preparation for animals and its preparation method

A core-shell structure, zinc oxide technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, drug combinations, etc., can solve problems such as environmental pollution, animal intestinal discomfort, pollution of groundwater, etc. The effect of reducing soil environmental pollution, reducing breeding costs, and reducing zinc emissions

Active Publication Date: 2019-08-13
ZHEJIANG FENGHONG NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the residual zinc content in feces is about half of the added amount, such a high dose of zinc accumulates in the soil and causes environmental pollution
Long-term accumulation can cause the soil to no longer be arable
Moreover, zinc is highly toxic to fish and aquatic organisms
Excess zinc excreted by livestock will seriously pollute groundwater and hinder the sustainable development of animal husbandry
2) Cause high zinc dependence of piglets, which will have adverse effects on later growth
But too much oleic acid can cause intestinal discomfort in animals

Method used

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  • A core-shell structure zinc oxide clay antidiarrheal preparation for animals and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 200g of zinc oxide, spray a small amount of water into the granulation equipment, and bind the zinc oxide into small particles. Weigh 300g of montmorillonite powder, gradually add it to the granulation equipment equipped with zinc oxide particles, start the equipment to make the montmorillonite powder evenly adhere to the surface of zinc oxide particles, and add an appropriate amount of water to promote the adhesion of montmorillonite powder . Then 6g of alginate was dissolved in the mixed solution of alcohol and water, and sprayed onto the surface of zinc oxide / montmorillonite particles to form a layer of gastric protection film. The granules are dried and sieved to obtain the product.

Embodiment 2

[0031] Weigh 300g of zinc oxide, spray a small amount of starch aqueous solution into the granulation equipment, and sterilize the zinc oxide to bond into small particles. Weigh 600g of montmorillonite powder, gradually add it to the granulation equipment equipped with zinc oxide particles, start the equipment to make the montmorillonite powder evenly adhere to the surface of the zinc oxide particles, and add an appropriate amount of water to promote the adhesion of the montmorillonite powder . Then, 10 g of polyvinyl alcohol acetate phthalate was dissolved in an alcohol-water mixed solution, and sprayed onto the surface of the zinc oxide / montmorillonite particles to form a layer of gastric protection film. The granules are dried and sieved to obtain the product.

Embodiment 3

[0033] Weigh 200g of zinc oxide, spray a small amount of starch aqueous solution into the granulation equipment, and sterilize the zinc oxide to bond into small particles. Weigh 200g of zeolite powder and gradually add it to the granulation equipment equipped with zinc oxide particles, start the equipment to make the montmorillonite powder evenly adhere to the surface of the zinc oxide particles, and add an appropriate amount of water to promote the adhesion of the montmorillonite powder. Then the 15 fatty acid is dissolved in the mixed solution of alcohol and water, and sprayed onto the surface of the zinc oxide / montmorillonite particles to form a gastric protection film. The granules are dried and sieved to obtain the product.

[0034] The coated zinc oxide samples of Examples 1, 2, 3 and common zinc oxide were subjected to a comparison test of diarrhea frequency under the same feeding conditions. The calculation method of food diarrhea frequency is:

[0035] Diarrhea freq...

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PUM

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Abstract

The invention belongs to the field of animal health-care, and in particular relates to a zinc oxide anti-diarrhea product for animals and a preparation method thereof. The core-shell structured zinc oxide clay anti-diarrhea preparation for animals is granular, the core layer of a granule is zinc oxide, the outer layer of the zinc oxide is enveloped with a clay layer, and the outer layer of the granule is enveloped with an enteric coating. The anti-diarrhea preparation is free from erosion of gastric acid and is released in fixed points in the intestinal tract. The clay can converge damaged epithelial cells in the intestinal tract, protect the intestinal tract, and substitute for antibiotics for controlling diarrhea. The dosage of the anti-diarrhea preparation is far less than the dosage of zinc oxide, thereby lowering the culturing cost and reducing zinc discharge and soil environment pollution.

Description

technical field [0001] The invention belongs to the field of animal health care, in particular to a zinc oxide anti-diarrhea product for animals and a preparation method thereof. Background technique [0002] Zinc is an essential trace element in animals, a component of various enzymes, and participates in the metabolism of nutrients such as fat, carbohydrates, and vitamins. A large number of studies in the fields of medicine and animal nutrition have found that zinc is closely related to the immune function of the body, affecting the specific, non-specific and intestinal mucosal immune function, and plays an important role in maintaining the normal immune function of the body and preventing bacteria and parasites. Good effect on invasion. Studies have shown that adding high doses of zinc oxide to diets can reduce diarrhea and increase daily weight gain in weaned piglets. Scholars at home and abroad have conducted extensive research on the application effect of adding high ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/30A61K9/50A61K47/02A61K47/36A61K47/32A61K47/12A61P1/12
CPCA61K9/501A61K9/5015A61K9/5026A61K9/5036A61K33/30
Inventor 王春伟李静静詹小立黄灿
Owner ZHEJIANG FENGHONG NEW MATERIAL