Yuanhuzhitong dropping pills and method for extracting and preparing active ingredients of Yuanhuzhitong dropping pills

A technology of Yuanhu Zhitong dripping pills and active components, which is applied to medical preparations containing active ingredients, non-central analgesics, pill delivery, etc. It can solve problems such as inconvenient carrying, complicated process, and bitter taste, and achieve The effect of remarkable curative effect, simple preparation and stable quality

Inactive Publication Date: 2017-03-15
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN200610107202 oral preparation, inconvenient to carry, bitter taste; CN200910203555 soft capsule

Method used

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  • Yuanhuzhitong dropping pills and method for extracting and preparing active ingredients of Yuanhuzhitong dropping pills
  • Yuanhuzhitong dropping pills and method for extracting and preparing active ingredients of Yuanhuzhitong dropping pills
  • Yuanhuzhitong dropping pills and method for extracting and preparing active ingredients of Yuanhuzhitong dropping pills

Examples

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preparation example Construction

[0093] An effective component extraction and preparation method of Yuanhu Zhitong dripping pill preparation, comprising the following steps:

[0094] A. Corydalis vinegar

[0095] Corydalis and vinegar are mixed at a weight ratio of 5:1, stored in a sealed container for 24 hours, then dried in an oven for 8 hours, and then allowed to cool;

[0096] B. Mixed extraction of medicinal materials

[0097] Vinegar Corydalis and Angelica dahurica are mixed in a weight ratio of 2:1, vinegar Corydalis and Angelica are crushed to 1-8 mm, extracted with organic extract and concentrated to form a concentrate;

[0098] C. Multi-stage extraction

[0099] Put the concentrated solution in a separatory funnel, sequentially add petroleum ether, chloroform, and water-saturated n-butanol for extraction, depressurize and recover the solvent from each extraction site respectively to obtain petroleum ether extract, chloroform extract, and n-butanol extract, and extract each of the above The extrac...

Embodiment 1

[0112] A Yuanhu Zhitong dripping pill preparation is formulated according to the following components by weight: 1 part of active ingredient extract and 1 part of water-soluble base. The water-soluble base is a mixture of poloxamer 188 and polyoxyl (40) stearate.

[0113] An effective component extraction and preparation method of Yuanhu Zhitong dripping pill preparation, comprising the following steps:

[0114] A. Corydalis vinegar

[0115] Corydalis and vinegar are mixed at a weight ratio of 5:1, stored in a sealed container for 24 hours, then dried in an oven for 8 hours, and then allowed to cool;

[0116] B. Mixed extraction of medicinal materials

[0117] Vinegar Corydalis and Angelica dahurica medicinal materials are added to soak in 50% ethanol with a mass concentration twice the weight of the medicinal materials for 12 hours, heated and refluxed for 2 hours at a heating temperature of 60-75°C, the extract is collected, and then added with 50% ethanol with a mass conc...

Embodiment 2

[0125] A Yuanhu Zhitong dripping pill preparation is formulated according to the following components by weight: 1 part of active ingredient extract and 3 parts of water-soluble base. The water-soluble base is one or more mixtures of polyethylene glycol base and polyoxyl (40) stearate. The polyethylene glycols are selected from one or a combination of PEG-2000, PEG-4000, PEG-6000, and PEG-8000.

[0126] An effective component extraction and preparation method of Yuanhu Zhitong dripping pill preparation, comprising the following steps:

[0127] A. Corydalis vinegar

[0128] Corydalis and vinegar are mixed at a weight ratio of 5:1, stored in a sealed container for 24 hours, then dried in an oven for 8 hours, and then allowed to cool;

[0129] B. Mixed extraction of medicinal materials

[0130] Vinegar Corydalis and Angelica dahurica medicinal materials are added to soak in 70% ethanol with a mass concentration 4 times the weight of the medicinal materials for 36 hours, heated...

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Abstract

The invention relates to a method for extracting active ingredients of Yuanhuzhitong dropping pills and a preparation method of Yuanhuzhitong dropping pills. The method comprises the following steps: taking coarse powder of cleansing rhizoma corydalis and radix angelicae according to a ratio, extracting by using an organic solvent, collecting the extract, filtering, performing vacuum concentration on the filtrate so as to obtain extract without alcohol taste; sequentially adding petroleum ether, chloroform and water-saturated n-butyl alcohol into the extract for fully extracting by utilizing an organic solvent extraction technology, performing reduced pressure solvent recovery on each extracting part, thereby obtaining an active ingredient extract; preparing the Yuanhuzhitong dropping pill preparation by using the active ingredient extract. The invention further discloses a method for preparing the active ingredient extract and water-soluble base dropping pill preparation. The preparation disclosed by the invention is fast in dissolution, fast in absorption, rapid in efficacy and lasting in effects of relieving various kinds of pain, has the effects of regulating the flow of vital energy, invigorating the circulation of blood and relieving pain and can be used for treating the symptoms such as qi stagnation and blood stasis type stomachache, costalgia and dysmenorrhea.

Description

technical field [0001] The invention relates to a Yuanhuzhitong dripping pill and its effective component extraction and preparation method. Background technique [0002] Pain is a complex physiological and psychological activity, and it is one of the most common clinical symptoms. It includes the pain sensation caused by noxious stimuli acting on the body, and the body's pain response to noxious stimuli (body motor response and / or visceral vegetative response, often accompanied by strong emotional color). Pain can be used as a warning that the body is injured, causing a series of defensive protective reactions of the body. But on the other hand, pain also has its limitations as an alarm (such as when pain occurs in cancer, it is too late). And some long-term severe pain has become a kind of unbearable torture to the body. Therefore, analgesia is an important task facing medical workers. [0003] Clinically used analgesics are generally divided into two categories, narco...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/20A61P29/00A61P1/00A61P25/00A61P15/00
CPCA61K9/2031A61K36/232A61K36/66A61K2236/333A61K2236/35A61K2300/00
Inventor 任一杰仲万春魏晋君贾继禧邓月婷卢英张政张恒瑞王小芳张智
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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