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A kind of traditional Chinese medicine granules for treating alcoholic liver injury

A technology of alcoholic liver injury and traditional Chinese medicine granules, applied in the field of medicine, can solve problems such as low curative effect, increased burden on the liver, and unsatisfactory

Active Publication Date: 2019-07-26
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional Chinese medicine has its unique advantages in the treatment of chemical liver damage. Traditional Chinese medicine with the same source of medicine and food does not increase the burden on the liver, has few side effects, is safe and effective, and is more acceptable to the public. The early treatment of liver injury has an irreplaceable role. However, although there are many traditional Chinese medicine preparations for the treatment of alcoholic liver injury in clinical practice, there are few raw materials with the same origin of traditional Chinese medicine and food. They are often taken, and there are still side effects, and they are effective. Slow, low efficacy, unsatisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] The present invention is prepared from the following raw materials by weight: 30 grams of capillary, 20 grams of gardenia, 30 grams of medlar, 20 grams of schisandra, 20 grams of coix seed, 30 grams of kudzu root, 15 grams of black plum, 9 grams of licorice and jujube 30 grams, wherein, the above-mentioned raw medicines are mixed together, each time adding water 8 times the weight of the raw medicines, decocting 2 times, 1 hour each time, before decocting, first soak for 30 minutes, then start decocting, combine two decoctions Boil the liquid, filter, and concentrate the filtrate under reduced pressure to an extract with a thermal relative density of 1.0 at 60°C, vacuum-dry at 60°C, and pulverize to obtain a dry extract powder, add auxiliary materials, and the weight ratio of the dry extract powder to auxiliary materials is 1: 0.8, stir evenly, add the ethanol that mass concentration is 90% as wetting agent, the ethanol addition is 30%-50% of the total weight of auxiliar...

Embodiment 2

[0011] The present invention is prepared from the following raw materials by weight: 15 grams of capillary, 10 grams of gardenia, 15 grams of medlar, 10 grams of schisandra, 10 grams of coix seed, 15 grams of kudzu root, 9 grams of black plum, 6 grams of licorice and jujube 12 grams, of which, the above raw materials are mixed together, each time adding water 8 times the weight of the raw drug, decocting twice, each time for 1 hour, before decocting, first soak for 30 minutes, then start decocting, combine two decoctions liquid, filtered, and the filtrate was concentrated under reduced pressure to an extract with a thermal relative density of 1.1 at 60°C, vacuum-dried at 60°C, and pulverized to obtain a dry extract powder, adding auxiliary materials, and the weight ratio of the dry extract powder to auxiliary materials was 1:0.8 , stir evenly, add ethanol with a mass concentration of 90% as a wetting agent, and the amount of ethanol added is 30%-50% of the total weight of auxil...

Embodiment 3

[0013] The present invention is prepared from the following raw materials by weight: 20 grams of capillary, 10 grams of gardenia, 15 grams of medlar, 9 grams of schisandra, 9 grams of coix seed, 15 grams of kudzu root, 9 grams of black plum, 6 grams of licorice and jujube 9 grams, of which, the above raw materials are mixed together, each time adding water 8 times the weight of the raw drug, decocting twice, each time 1h, before decocting, first soak for 30min, then start decocting, combine two decoctions liquid, filtered, and the filtrate was concentrated under reduced pressure to an extract with a thermal relative density of 1.2 at 60°C, vacuum-dried at 60°C, and crushed to obtain a dry extract powder, adding auxiliary materials, and the weight ratio of the dry extract powder to auxiliary materials was 1:0.8 , stir evenly, add ethanol with a mass concentration of 90% as a wetting agent, and the amount of ethanol added is 30%-50% of the total weight of auxiliary materials and ...

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PUM

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Abstract

The invention relates to traditional Chinese medicinal granules for treating alcoholic liver injury, in order to effectively solve the problem of treating the alcoholic liver injury under the precondition of not increasing liver burden. The traditional Chinese medicinal granules are prepared from the following medicinal raw materials by weight: 15-30g of herba artemisiae scopariae, 10-20g of fructus gardeniae, 15-30g of fruit of Chinese wolfberry, 9-20g of fruit of Chinese magnoliavine, 9-20g of coix seeds, 15-30g of radix puerariae, 9-15g of dark plums, 6-9g of liquorice root and 9-30g of fructus ziziphi jujubae. The traditional Chinese medicinal granules are prepared by the following steps: mixing the medicinal raw materials, soaking the mixed raw materials and decocting the mixed raw materials twice with the addition of water, combing two times of decoctions, conducting filtering, decompressing and concentrating an obtained filtrates so as to obtain an extractum, conducting vacuum drying, crushing the dried extractum so as to obtain dried extractum powder, adding adjuvants, uniformly stirring all materials, adding ethanol as a wetting agent, uniformly stirring all materials, conducting sieving so as to obtain wet granules, and drying and straightening the granules, so that the traditional Chinese medicinal granules are obtained. The traditional Chinese medicinal granules provided by the invention have functions of clearing heat and inducing diuresis, nourishing yin and softening liver; and the traditional Chinese medicinal granules take a good curative effect in the aspect of preventing and treating the alcoholic liver injury, being innovation of medicines for treating the alcoholic liver injury.

Description

technical field [0001] The invention relates to the field of medicine, in particular to traditional Chinese medicine granules for treating alcoholic liver injury. Background technique [0002] Excessive drinking and alcoholism have increasingly become serious problems affecting human health. Alcoholism causes 2.5 million deaths every year in the world, accounting for 4% of the mortality rate, and alcoholic liver disease (alcoholic liver disease, ALD) caused by alcoholism is the most leading cause of death. Alcoholic liver disease has become the second leading liver disease in some regions. The liver is the main site for metabolizing alcohol and drugs. Clinically, drugs for the treatment of alcoholic liver injury will increase the burden on the liver. Therefore, the development of safe drugs with less side effects has important guiding significance in the treatment of liver injury. [0003] Traditional Chinese medicine has its unique advantages in the treatment of chemical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/16A61P1/16
CPCA61K9/1652A61K36/28A61K36/484A61K36/488A61K36/57A61K36/725A61K36/736A61K36/744A61K36/79A61K36/815A61K36/8994A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 朱平生苗明三付双楠高达郭佳佳乔靖怡
Owner HENAN UNIV OF CHINESE MEDICINE
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