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Zinc oxide quantum dot with stable biology base and preparation method thereof

A zinc oxide, bio-based technology, applied in the direction of chemical instruments and methods, luminescent materials, etc., can solve the problems that hinder the application of biological materials, ZnO quantum dot dispersion is not satisfactory, etc., achieve good stability and simple preparation process

Inactive Publication Date: 2017-03-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no matter what method is used, the dispersion of pure ZnO quantum dots in water is not satisfactory, which also hinders its application in biomaterials.

Method used

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  • Zinc oxide quantum dot with stable biology base and preparation method thereof
  • Zinc oxide quantum dot with stable biology base and preparation method thereof
  • Zinc oxide quantum dot with stable biology base and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of sulfobetaine trimethoxy silylating reagent (referred to as SBS)

[0030] Dissolve 1g (8.19mmol) of 1'3-propane sultone in 10mL of anhydrous acetone, in an ice-water bath, N 2 Under protective conditions, 1.685g (8.13mmol) N'N-dimethyl-3-aminopropyl-trimethoxysilane was slowly added dropwise, stirred and reacted for 6h after dropping, centrifuged to obtain a white precipitate, washed with anhydrous acetone for several 2.42 g of the sulfobetaine trimethoxy silylating agent can be obtained by vacuum drying overnight.

[0031] (2) Preparation of bio-based stable ZnO quantum dots

[0032] 0.816g (3.72mmol) Zn(Ac) 2 2H 2 O was added to 20 mL of absolute ethanol, refluxed at 68°C for 90 min, and then cooled to room temperature to obtain a zinc acetate ethanol dispersion. 0.460g (8.22mmol) KOH was added into 10mL of absolute ethanol, and ultrasonically dissolved to obtain a KOH ethanol solution. Slowly add the obtained KOH ethanol solution dropwise into ...

Embodiment 2

[0039] (1) Preparation of sulfobetaine trimethoxy silylating reagent (referred to as SBS)

[0040] Dissolve 1g (8.19mmol) of 1'3-propane sultone in 10mL of anhydrous acetone, in an ice-water bath, N 2Under protective conditions, 1.685g (8.13mmol) N'N-dimethyl-3-aminopropyl-trimethoxysilane was slowly added dropwise, stirred and reacted for 6h after dropping, centrifuged to obtain a white precipitate, washed with anhydrous acetone for several 2.42 g of the sulfobetaine trimethoxy silylating agent can be obtained by vacuum drying overnight.

[0041] (2) Preparation of bio-based stable ZnO quantum dots

[0042] 0.816g (3.72mmol) Zn(Ac) 2 2H 2 O was added to 20 mL of absolute ethanol, refluxed at 68°C for 90 min, and then cooled to room temperature to obtain a zinc acetate ethanol dispersion. 0.460g (8.22mmol) KOH was added into 10mL of absolute ethanol, and ultrasonically dissolved to obtain a KOH ethanol solution. Slowly add the obtained KOH ethanol solution dropwise into t...

Embodiment 3

[0044] (1) Preparation of sulfobetaine trimethoxy silylating reagent (referred to as SBS)

[0045] Dissolve 1g (8.19mmol) of 1'3-propane sultone in 10mL of anhydrous acetone, in an ice-water bath, N 2 Under protective conditions, 1.685g (8.13mmol) N'N-dimethyl-3-aminopropyl-trimethoxysilane was slowly added dropwise, stirred and reacted for 6h after dropping, centrifuged to obtain a white precipitate, washed with anhydrous acetone for several 2.28 g of the sulfobetaine trimethoxy silylating agent can be obtained by vacuum drying overnight.

[0046] (2) Preparation of bio-based stable ZnO quantum dots

[0047] 0.816g (3.72mmol) Zn(Ac) 2 2H 2 O was added to 20 mL of absolute ethanol, refluxed at 68°C for 90 min, and then cooled to room temperature to obtain a zinc acetate ethanol dispersion. 0.460g (8.22mmol) KOH was added into 10mL of absolute ethanol, and ultrasonically dissolved to obtain a KOH ethanol solution. Slowly add the obtained KOH ethanol solution dropwise into ...

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Abstract

The invention provides a zinc oxide quantum dot with stable biology base. The preparation method of the zinc oxide quantum dot is as follows: dropwise adding a KOH ethanol liquid to zinc acetate ethanol dispersion liquid, stirring and reacting for 0.5-1h at room temperature to prepare the zinc acetate ethanol dispersion liquid; replenishing deionized water A in the obtained zinc acetate ethanol dispersion liquid, dropwise adding the ethanol liquid of a zwitter-ion silylating reagent, stirring and reacting for 2-3h at room temperature after completely dropwise adding, centrifuging, collecting the precipitate, namely, the zinc oxide quantum dot with stable biology base, washing by use of methanol, dispersing in the deionized water B for storage. The preparation process is simple, the particle size of the obtained zinc oxide quantum dot with stable biology base is 2-5nm, and the obtained zinc oxide quantum dot has good stability in slightly alkaline aqueous liquid, sodium chloride liquid and serum liquid, the corresponding dispersion liquid nearly has no change after standing for one month, and the clarification and the transparency are still maintained.

Description

[0001] (1) Technical field [0002] The invention relates to a bio-based stable zinc oxide quantum dot and a preparation method thereof, belonging to the technical field of functional nanoparticles. [0003] (2) Background technology [0004] As a wide bandgap semiconductor, ZnO has a direct bandgap energy of 3.3eV and an exciton binding energy of 60mV, making it widely used in optics, electricity, and catalysis. Especially in the field of biomarkers, it has good application prospects, and has the advantages of non-toxicity and low cost compared with the reported CdSe and the like. And because ZnO can be dissolved when the pH is less than 5.5 and has pH responsiveness, it also has great application potential in the controlled release of drugs. [0005] The common preparation methods of ZnO quantum dots include gas phase preparation method, liquid phase preparation method and solid phase preparation method, among which the liquid phase method can be divided into precipitation m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/54C09K11/06
CPCC09K11/02C09K11/06C09K11/54
Inventor 张静陈佳达
Owner ZHEJIANG UNIV OF TECH