IP10 and Eotaxin combined cell factor for diagnosing tuberculosis and kit thereof

A cytokine and IP-10 technology, applied in the field of disease diagnosis, can solve problems such as low accuracy of tuberculosis, sensitivity and specificity that cannot meet clinical requirements, and insufficient detection performance of IFN-γ, so as to improve diagnostic ability and high Effects of Sensitivity and Specificity

Inactive Publication Date: 2017-04-19
SHANGHAI RONGSHENG BIOLOGICAL PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as the only detection target of IFN-γ in the existing commercial Mycobacterium tuberculosis infection cell immunoassay reagents, its sensitivity and specificity cannot meet the clinical requirements. The reason may be the detection performance of IFN-γ on the one hand. Not high enough, some studies have shown that its accuracy in dia

Method used

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  • IP10 and Eotaxin combined cell factor for diagnosing tuberculosis and kit thereof
  • IP10 and Eotaxin combined cell factor for diagnosing tuberculosis and kit thereof
  • IP10 and Eotaxin combined cell factor for diagnosing tuberculosis and kit thereof

Examples

Experimental program
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Example Embodiment

[0040] Example 1

[0041] In the study, the plasma of newly diagnosed and healthy pulmonary tuberculosis patients was tested to detect the levels of five cytokines, IFN-γ, IL-6, IP-10, Eotaxin and RANTES.

[0042] IFN-γ, IL-6, Eotaxin, IP-10 and RANTES five cytokines in the plasma of 213 newly diagnosed pulmonary tuberculosis patients and 29 healthy subjects (mean ± standard deviation) statistics (see Table 1). Make two sets of scatter plots based on the data. The levels of IL-6, Eotaxin, IP-10 and RANTES in the plasma of newly diagnosed pulmonary tuberculosis patients were significantly higher than those of healthy persons (P figure 1 B. figure 1 C, figure 1 D and figure 1 E), the difference of IFN-γ between the two groups is not statistically significant ( figure 1 A).

[0043] Table 1 The levels of cytokines in the plasma of newly diagnosed pulmonary tuberculosis patients and healthy subjects

[0044] (Mean ± standard deviation)

[0045]

[0046] ROC curves of plasma cytokines in n...

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Abstract

The invention discloses an application of cell factors (IP-10 and Eotaxin) taken as a combined marker in the preparation of a kit for diagnosing or monitoring tuberculosis. The provided cell factors and a combination thereof can detect cell factors in the blood plasma of patients in the newly diagnosed patients. The diagnosing performance on lung tuberculosis is prominently improved, and the disease and treatment can be better predicted.

Description

technical field [0001] The invention relates to a disease diagnosis technique, in particular to a cytokine for diagnosing tuberculosis and a kit for detecting these cytokines. Background technique [0002] Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB). According to the statistics of WHO in 2014, there were 930,000 new cases of tuberculosis in my country, among the 22 countries with a high burden of tuberculosis. Ranked third after India and Indonesia, tuberculosis is the chronic infectious disease with the highest single-factor fatality rate in my country. Epidemiology shows that about 1 / 3 of the world's population is a carrier of Mycobacterium tuberculosis, and about 10% of the carriers can develop active tuberculosis [2]. With the prevalence of multidrug resistance tuberculosis cle bacillus (MDR-TB) and the increase of human immunodeficiency virus (Human immunodeficiency vinus, HIV) infection, the infection of Mycobacterium tu...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6863G01N33/6893G01N2333/522G01N2333/54G01N2333/5406G01N2333/5412G01N2333/7155G01N2333/7158G01N2800/12
Inventor 冯晓燕张贺秋朱绍荣杨锡琴
Owner SHANGHAI RONGSHENG BIOLOGICAL PHARM CO LTD
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