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A kind of antiviral traditional Chinese medicine compound preparation and preparation method thereof

A compound preparation, antiviral technology, applied in the direction of antiviral agents, pharmaceutical formulations, medical preparations with inactive ingredients, etc. Bioavailability, effectiveness in overcoming stability problems

Active Publication Date: 2018-01-09
GUANGZHOU KNOCKIM PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Houtongling granules prepared by traditional methods have many defects such as low bioavailability, bad taste, and unstable storage due to the hygroscopicity of traditional Chinese medicine. At the same time, due to the poor taste of traditional Chinese medicine, children's compliance is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 150g of wild chrysanthemum, 200g of Radix Radix, 150g of Schizonepetae, and 20g of buffalo horn concentrated powder, impregnate with 95% ethanol for 24 hours, heat and reflux 3 times, each time for 3 hours, recover under reduced pressure, dry to obtain the extract, and extract Mix it with 20 g of buffalo horn concentrated powder to obtain a compound Chinese medicine composition; take the compound Chinese medicine composition and solid dispersion carrier material and dissolve them in ethanol and mix them, then ultrasonicate the solution for 30 minutes, then spray dry, and pass the obtained dry powder through a 100-mesh sieve to obtain Solid dispersion. The solid dispersion carrier material is a mixture of xylitol and povidone in a weight ratio of 1:2, and the povidone is a mixture of povidone K30 and povidone K90 in a weight ratio of 1:1. The weight ratio of the dispersion carrier is 1:5; 1 part of solid dispersion, 2 parts of microcrystalline cellulose, 5 parts of...

Embodiment 2

[0018] Weigh 150g of wild chrysanthemum, 200g of Radix Radix, 150g of Schizonepetae, and 20g of buffalo horn concentrated powder, impregnate with 80% ethanol for 24 hours, heat and reflux 3 times, each time for 2 hours, recover under reduced pressure, dry to obtain the extract, and extract Mix it with 20 g of buffalo horn concentrated powder to obtain a compound Chinese medicine composition; take the compound Chinese medicine composition and solid dispersion carrier material and dissolve them in ethanol and mix them, then ultrasonicate the solution for 30 minutes, then spray dry, and pass the obtained dry powder through a 100-mesh sieve to obtain Solid dispersion. The solid dispersion material is a mixture of lactose and hydroxypropyl methylcellulose with a weight ratio of 1:1, and the weight ratio of the compound Chinese medicine composition to the solid dispersion carrier is 1:10; 1 part of the solid dispersion, microcrystalline fiber 1 part of starch, 2 parts of compressibl...

Embodiment 3

[0020] Experiment content: Pharyngitis drug efficacy test

[0021] Material:

[0022] Experimental animals: Japanese white rabbits, body weight 2.0KG±0.1, half male and half male, 30 experimental animals in total, divided into 3 groups, 10 rabbits in each group.

[0023] Experimental group: prepared in Example 1.

[0024] Blank administration group: placebo blank distilled water.

[0025] Control group: commercially available Houtongling Granules.

[0026] Experimental method: Spray 2.5% ammonia water 0.05mL·kg (approximately 3 presses) in the throat of the rabbit every morning from the 1st to 10th day, inject 25% turpentine 0.2mL·kg with tonsil injection needle respectively on the 11th day Submucosal on the left and right sides of the rabbit's pharynx, from the 21st day to the 30th day, the drug prepared in Example 1, blank administration, and commercially available Houtongling granules were administered respectively, and the dosages of the experimental group and the contr...

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PUM

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Abstract

The invention relates to an antiviral traditional Chinese medicine compound preparation, and especially relates to a solid dispersant granule containing the traditional Chinese medicine compound preparation capable of relieving laryngalgia. The traditional Chinese medicine compound preparation is composed of 150g of flos chrysanthemi indici, 200g of radix isatidis, 150g of herba schizonepetae, and 20g of cornu bubali concentrated powder; a solid dispersant carry material is composed of a water soluble carrier and a high-molecular material; the water soluble carrier is selected from urea, citric acid, lactose, and xylitol; the high-molecular material is selected from polymaleic anhydride, povidone, and hydroxypropyl methyl cellulose; and the weight ratio of the traditional Chinese medicine compound preparation to the solid dispersant carrier material is controlled to be 1:10-10:1.

Description

technical field [0001] The invention relates to an antiviral traditional Chinese medicine compound preparation and a preparation method thereof, in particular to a granule of an antiviral traditional Chinese medicine compound preparation and a preparation method thereof. Background technique [0002] Houtongling Granules are composed of Radix Radix Nepeta, Wild Chrysanthemum, and Buffalo Horn Concentrated Powder. It has the functions of clearing away heat, detoxifying, reducing inflammation, and benefiting the throat. It is clinically used for pharyngitis, acute suppurative tonsillitis, and cold fever. , upper respiratory tract inflammation, boils, etc. The traditional granule preparation is to extract 150g of wild chrysanthemum, 200g of Radix Radix, and 150g of Schizonepetae with water, precipitate the extract with alcohol, concentrate the supernatant to obtain the extract, mix the extract with 20g of buffalo horn concentrated powder, and use it as the active ingredient of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/538A61K9/16A61K47/32A61K47/10A61P31/12A61P11/04A61P31/14A61P11/00A61P17/02A61K35/32
CPCA61K9/1623A61K9/1652A61K35/32A61K36/195A61K36/287A61K36/315A61K36/538A61K2236/333A61K2236/39A61K2300/00
Inventor 黄德欢
Owner GUANGZHOU KNOCKIM PHARMA