External used medicine for treating chronic diarrhea and use method of external used medicine

A technology for topical drugs and chronic diarrhea, which is applied in drug delivery, drug combination, and pharmaceutical formulations. It can solve the problems of many adverse reactions and achieve the effects of promoting transdermal absorption, improving mental state, and simple operation.

Inactive Publication Date: 2017-05-10
ZHANGJIAGANG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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AI-Extracted Technical Summary

Problems solved by technology

There are many drugs and methods for the treatment of IBS-D, but none of them can completely and effectively treat all types of IBS-D
With the rapid progress of drug research and development, certain...
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Abstract

The invention discloses an external used medicine for treating chronic diarrhea. The external used medicine is prepared from the following raw material medicines in percentage by weight: 1.9 to 2.1 of fructus psoraleae, 0.95 to 1.05 percent of myristica fragrans, 0.95 to 1.05 percent of fructus chebulae, 0.95 to 1.05 percent of flos caryophylli and 0.95 to 1.05 percent of yams. The external used medicine has the advantages that the due to external application, the medicine is convenient, cheap, safe and side-effect-free, and has the advantages of effectively relieving stomachache and abdominal discomfort of a IBS-D patient, reducing defection frequency, improving the stool property, improving symptoms of insufficiency of both the spleen and the kidney such as poor mental state and soreness and weakness of waist and knees.

Application Domain

Digestive systemMedical devices +2

Technology Topic

External applicationSide effect +12

Examples

  • Experimental program(1)

Example Embodiment

[0013] The present invention will be further described below in conjunction with specific embodiments.
[0014] Said external medicine for the treatment of chronic diarrhea is composed of the following raw materials in weight ratio: Psoralen: nutmeg: myrobalan: male clove: yam = (1.9~2.1): (0.95~1.05): (0.95) ~1.05):(0.95~1.05):(0.95~1.05); The preferred weight ratio is: psoralen: nutmeg: myrobalan: male clove: yam=2:1:1:1:1;
[0015] The method of using the external medicine for treating chronic diarrhea includes the following steps:
[0016] (1) First develop the topical medicine into powder, and use ginger juice to make a cake shape with the middle slightly higher than the periphery, and then place the cake-like topical medicine on the sanitary dressing;
[0017] (2) Apply the external medicine made into a cake in step (1) on the patient's umbilicus through a sanitary dressing;
[0018] (3) Next, the electromagnetic wave therapy device is vertically suspended 30cm above the umbilicus, and the electromagnetic wave therapy device's spectrum range is set to (2.5~20) μm, and the power is set to 350W, and then the electromagnetic wave therapy device is applied to The topical medicine in the patient's umbilical area is heated to warmth.
[0019] The following clinical trials illustrate the beneficial effects of the drug of the present invention:
[0020] 1. General conditions and test methods: In order to confirm the clinical efficacy of the drug of the present invention, 63 confirmed spleen-kidney-yang tiger type IBS-D patients were used. Consensus Opinions on Chinese Medicine Diagnosis and Treatment 2010. 63 patients were randomly divided into treatment group and control group. Among them, 33 cases in the treatment group included: 12 males and 21 females, aged from 16 to 52 years, with an average age (26.45±9.07), and the course of disease was 3 months to 15 years. , The average course of disease is (25.64±41.70) months, the control group includes: 11 males and 19 females, aged from 17 to 60 years old, average age (29.13±11.96), course of disease 3 months to 20 years, average course of disease (36.93) ±74.16) month. The treatment group all used the topical drugs and topical drug application methods of the present invention for external application of umbilical therapy, while the control group used pinaverium bromide (Desutte) produced by Abbott Healthcare SAS (approval number: H20120127). The treatment time of the two groups was 10 days as a course of treatment.
[0021] 2. Clinical observation curative effect standard: According to the "Guiding Principles for Clinical Research of New Chinese Medicines", the frequency, volume and characteristics of stool return to normal, and the symptoms and signs disappear as clinical recovery; the number of stools is 2-3 times a day, approximately forming, or stool Only once a day is markedly effective; the frequency and quality of bowel movements are improved to be effective; those that fail to meet the above standards or deteriorate are invalid.
[0022] 3. Observation results of the efficacy of the two groups: the treatment group was clinically cured 6 cases, markedly effective 16 cases, effective 5 cases, and ineffective 6 cases, the total effective rate reached 81.82%; the control group clinically cured 4 cases, markedly effective 6 cases, effective 12 cases, ineffective In 8 cases, the total effective rate was 73.33%. Using chi-square test, P=0.046, chi-square value 7.989, the total effective rate of the treatment group was significantly better than that of the control group, indicating that the external medicine and method of the present invention can effectively alleviate abdominal pain, abdominal discomfort, and reduce stool frequency in patients with IBS-D. It is worthy of clinical promotion to improve stool characteristics.

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

  • relieve abdominal pain
  • reduce bowel movements

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