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Calcium magnesium silicofluoride biomaterial, preparation method and application

A technology of magnesium fluorosilicate and biological materials, which is applied in dental preparations, tissue regeneration, pharmaceutical formulations, etc., can solve problems such as weak interfacial bonding force, and achieve the effects of simple preparation method, no waste gas emission, and environmental friendliness.

Inactive Publication Date: 2017-05-17
JIANGSU NADN SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims at the deficiency that HA is deposited on the surface of existing inorganic biological implant materials, resulting in weak interfacial binding force, and provides a magnesium calcium fluorosilicate bioceramic material with good biological activity, a preparation method and its application

Method used

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  • Calcium magnesium silicofluoride biomaterial, preparation method and application
  • Calcium magnesium silicofluoride biomaterial, preparation method and application
  • Calcium magnesium silicofluoride biomaterial, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] According to Ca 2 Mg 5 Si 8 o 22 f 2 The molar ratio of the elements, weighed calcium oxide CaO: 0.56 grams, magnesium oxide MgO: 0.806 grams, silicon oxide SiO 2 : 2.4 g, grind and mix each compound evenly, pre-sinter under air atmosphere, the temperature is 350 ° C, the calcination time is 15 hours, then cool to room temperature, take out the sample; the pre-calcined raw material is again mixed with calcium fluoride CaF 2: 0.586g, fully mixed and ground evenly, the sintering temperature is 1200°C, the calcination time is 15 hours, then cooled to room temperature, and the sample is taken out; the mixed powder is pressed and molded, the pressure is 10MPa, and the sintering temperature is 850°C , calcined for 5 hours, and naturally cooled to obtain magnesium calcium fluorosilicate bioceramics.

[0035] See attached figure 1 , is the X-ray powder diffraction pattern of the magnesium calcium fluorosilicate bioceramic prepared according to the technical scheme of this...

Embodiment 2

[0041] According to Ca 2 Mg 5 Si 8 o 22 f 2 The molar ratio of the elements in the medium, weighed calcium carbonate CaCO 3 : 1.0009 grams, magnesium nitrate Mg (NO 3 ) 2 : 3.7 g, silicon oxide SiO 2 : 2.40336 g, ammonium fluoride NH 4 F: 0.463125 is ground in an agate mortar and mixed evenly, then pre-sintered in an air atmosphere, the temperature is 450 ° C, the calcination time is 12 hours, then cooled to room temperature, and the sample is taken out; the pre-calcined raw materials are fully mixed and ground, and calcined again The temperature is 1100°C, the time is 12 hours, then cooled to room temperature, and the sample is taken out; the mixed powder is pressed and molded, the pressure is 8MPa, and the ceramic sheet is sintered in the air atmosphere, the sintering temperature is 1000°C, and the calcination time is 6 hours. After cooling, the magnesium calcium fluorosilicate bioceramics can be obtained.

[0042] Put the prepared calcium magnesium fluorosilicate c...

Embodiment 3

[0045] According to Ca 2 Mg 5 Si 8 o 22 f 2 The molar ratio of the elements in the medium, weighed calcium hydroxide Ca(OH) 2 : 1.0009 g, magnesium carbonate basic 4MgCO 3 ·Mg(OH) 2 ·5H 2 O: 0.53532375 g, silicon oxide SiO 2 : 2.40336 g, ammonium fluoride NH 4 F: 0.3705 g, after grinding and mixing all the compounds, pre-sintering in air atmosphere, pre-sintering temperature 550 ° C, pre-sintering time 10 hours, then cool to room temperature, take out the sample; fully mix and grind the pre-calcined raw materials, The sintering temperature is 1000°C, the calcination time is 10 hours, then cooled to room temperature, and the sample is taken out; the mixed powder is pressed and molded at a pressure of 8 MPa, and calcined again in an air atmosphere at a temperature of 900°C, and the calcination time is 8 hours. A magnesium calcium fluorosilicate bioceramic is obtained.

[0046] Put the prepared calcium fluorosilicate ceramics into the simulated body fluid for mineraliza...

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Abstract

The invention discloses a calcium magnesium silicofluoride biomaterial, preparation method and application. Ca2Mg5Si8O22F2 powder is prepared and synthesized through a solid phase sintering method or a sol-gel method and is made into ceramic chips through tabletting and sintering. The obtained ceramic chips are put in a simulated body fluid for mineralization, hydroxyapatite layers are deposited on the ceramic surfaces, and the thickness of hydroxyapatite mineralization layers is increased with the mineralization time prolonged. The prepared calcium magnesium silicofluoride inorganic biological ceramic material is excellent in biocompatibility and biomineralization activity, can be taken as a bone tissue repairing material, a bone filling material and a dental material, and has bright application prospects in the biomedical field.

Description

technical field [0001] The invention relates to a magnesium calcium fluorosilicate bioceramic material, a preparation method and an application, and belongs to the technical field of inorganic biomaterials. Background technique [0002] At present, there is a large clinical demand for medical orthopedic biological implant materials. Inorganic bioimplantation materials should first have good biocompatibility. In order to improve their biocompatibility, the main method at present is to cover a layer of hydroxyapatite (HA) on the surface of the material. Because HA is an important component of bone and teeth, and HA has good biocompatibility, it is considered to be the most ideal artificial bone substitute material. Hydroxyapatite, prepared by mineralization on the surface of the implant, has a similar chemical composition and structure to the tissue surrounding the implant. In situ mineralized HA can induce the adhesion and proliferation of osteoblasts and realize the regene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/20C04B35/622C04B35/624C04B41/85A61L27/10A61K6/02
CPCA61K6/802A61L27/10A61L2430/02C04B35/20C04B35/622C04B35/624C04B41/5015C04B41/85C04B2235/3208C04B2235/3418C04B2235/445C04B2235/656C04B41/4535C04B41/455
Inventor 郑敏王作山杨泸
Owner JIANGSU NADN SCI TECH CO LTD