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A kind of preparation method of itaconic acid homopolymer graft carboxymethyl chitosan nanoparticle

A technology of carboxymethyl chitosan and itaconic acid homopolymer, applied in the field of preparation of itaconic acid homopolymer grafted carboxymethyl chitosan nanoparticles, to achieve convenient operation, low cost and simple preparation process Effect

Active Publication Date: 2019-05-17
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on the preparation of nanoparticles by intramolecular and intermolecular self-crosslinking of chitosan grafted with itaconic acid homopolymer after carboxymethylation at a specific pH

Method used

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Examples

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preparation example Construction

[0007] A method for preparing itaconic acid homopolymer grafted carboxymethyl chitosan nanoparticles is characterized in that it comprises the following steps: (1) dissolving carboxymethyl chitosan in deionized water to prepare carboxymethyl chitosan Sugar aqueous solution; under N2 protection, constant temperature at 60-80°C, and stirring at 500-1000 rpm, add itaconic acid aqueous solution and ammonium persulfate aqueous solution drop by drop to carboxymethyl chitosan aqueous solution at the same time, after the addition is completed, Continue to stir and react for 2~4 h; use NaOH solution to adjust the pH of the system to neutral to obtain itaconic acid homopolymer grafted with carboxymethyl chitosan; (2) itaconic acid homopolymer grafted with carboxymethyl chitosan Dissolve sugar in 0.1 mol / L HCl solution, add 0.1 mol / L NaOH solution drop by drop under stirring at 500~1000 rpm to adjust the pH until blue opalescence appears in the solution, continue to add NaOH solution drop...

Embodiment 2

[0013] Dissolve 3 g of O-carboxymethyl chitosan with a carboxymethyl substitution degree of 95% in 300 mL of distilled water to prepare an aqueous carboxymethyl chitosan solution with a concentration of 1% (w / v); under N2 protection, Under constant temperature at 80°C and stirring at 500 rpm, 20 mL of itaconic acid aqueous solution with a concentration of 30% (w / v) and 18 mL of itaconic acid with a concentration of 10% (w / v) were added dropwise to carboxymethyl chitosan aqueous solution / v) ammonium persulfate aqueous solution, after the dropwise addition, continue to stir for 2 h; use NaOH solution to adjust the pH of the system to neutral to obtain itaconic acid homopolymer grafted with carboxymethyl chitosan; 2 g of itaconic acid The homopolymer-grafted carboxymethyl chitosan was dissolved in 50 mL of 0.1 mol / L HCl solution, and 0.1 mol / L NaOH solution was added dropwise under the stirring condition of 800 rpm, and continued to drop after blue opalescence appeared. The NaOH...

Embodiment 3

[0015] Dissolve 0.5 g of N,O-carboxymethyl chitosan with a carboxymethyl substitution degree of 170% in 25 mL of distilled water to prepare a 2% (w / v) carboxymethyl chitosan aqueous solution; 10 mL of itaconic acid aqueous solution with a concentration of 20% (w / v) and 2.5 mL with a concentration of 8% (w / v) ammonium persulfate aqueous solution, after the dropwise addition, continue to stir and react for 4 h; use NaOH solution to adjust the pH of the system to neutral to obtain itaconic acid homopolymer grafted with carboxymethyl chitosan; 0.5 g Conic acid homopolymer grafted carboxymethyl chitosan was dissolved in 8 mL of 0.1 mol / L HCl solution, and 0.1 mol / L NaOH solution was added dropwise under the stirring condition of 600 rpm, and continued after blue opalescence appeared. NaOH solution was added dropwise to adjust the pH to 6, separated and purified, and dried to obtain itaconic acid homopolymer grafted carboxymethyl chitosan nanoparticles.

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Abstract

The invention relates to a preparation method of itaconic acid homopolymer grafted carboxymethyl chitosan nanoparticles and belongs to the field of biomedical materials. The method includes: firstly, grafting itaconic acid to carboxymethyl chitosan in a homopolymer mode to parepare the itaconic acid homopolymer grafted carboxymethyl chitosan, and then preparing the nanoparticles of the itaconic acid homopolymer grafted carboxymethyl chitosan through intermolecular and molecular self-crosslinking by adjusting the pH value. Adding of any crosslinking agents is not needed, use of an organic solvent is avoided, and safety and reliability are achieved; the method is convenient in operation, simple in preparation process and low in cost; the nanoparticles prepared are even in particle, good in dispersibility and stability repeatability, and good application development prospects in the fields of drug delivery, skin regeneration and medical material are achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a preparation method of itaconic acid homopolymer grafted with carboxymethyl chitosan nanoparticles. Background technique [0002] Nanoparticles have become one of the research hotspots in the field of biomedical materials due to their excellent characteristics such as large specific surface area, many surface active centers, high surface reactivity, high catalytic efficiency, and strong adsorption capacity. Chitosan has good biocompatibility, biodegradability and non-toxicity, and is widely used in the preparation of nanomaterials. The common preparation methods of chitosan nanoparticles include covalent cross-linking method, ionic cross-linking method and so on. In the covalent cross-linking method, glutaraldehyde is generally used as a cross-linking agent, but studies have found that the use of glutaraldehyde increases the cytotoxicity of nanoparticles. The ionic cross-linki...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F222/02A61K9/51A61K47/36A61K47/34
CPCA61K9/5146A61K9/5161C08F251/00C08F222/02
Inventor 刘成圣党奇峰殷艳艳刘恺高辉
Owner OCEAN UNIV OF CHINA
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