Cell growth scaffold with structural memory properties

Abstract

The invention relates to a cell growth scaffold with structural memory properties. The cell growth scaffold is a porous cell growth scaffold having no chemical crosslinking, having biological activity, having stable three-dimensional structure and having structural memory properties, and belongs to a porous material with special properties prepared by mixing fibers or a flocculent tissue material and an acidified hydrogel material at a certain ratio and carrying out treatment adopting the freezing / melting extrusion process and the radiation process. The scaffold has the excellent biological compatibility and the complete biodegradability, supports the growth of cells, also supports the growth of the in-vivo and in-vitro tissues and organs, and is particularly suitable for repairing the wounds and defects of the body soft tissue.

Description

technical field [0001] The invention relates to a cell growth scaffold applied in the fields of material science, tissue engineering and regenerative medicine, in particular to a cell growth scaffold with structure memory characteristics. Background technique [0002] Defects of human soft tissues are often caused by pathological changes, trauma or surgical operations. It is a difficult problem for modern medicine to regenerate the soft tissues needed by the human body itself. A variety of filling materials and dressings for soft tissue defect repair have been developed at home and abroad, including hydrogel and porous sponge filling materials based on synthetic polymer materials and natural biological materials. Using animal tissues as raw materials, collagen purified after acid treatment or enzyme treatment can be prepared into collagen hydrogels. Proper chemical cross-linking treatment can improve the stability of collagen in hydrogel preparations, and it is less prone to...

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Problems solved by technology

However, the existing problem is that the sponge material obtained by this method has poor structural strength and poor elasticity, is easily broken and deformed after being pressed, and cannot maintain the original material structure and cannot restore the original shape.

[0008] Summarizing the technical methods disclosed in the above documents, the prominent problem is: Whether using purified collagen hydrogel after acid hydrolysis or enzymatic hydrolysis, or tissue matrix material suspension homogenized after decellularization, when preparing porous collagen sponge material At present, the existing technology is to freeze-dry the hydrogel or suspension first, and then undergo further chemical cross-linking treatment to improve the mechanical strength of the material and enhance the stability of collagen in the sponge material. The chemical cross-linking treatment makes the tissue matrix The material loses many of its excellent natural properties as a porous cell growth scaffold

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