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Tumor thermotherapy pill and preparation device and process thereof

A technology for preparing devices and pills, which is applied to antitumor drugs, sugar-coated pills, drug combinations, etc., can solve the problems of difficult operation, overheating damage to healthy tissue, complex structure, etc., and achieves the effect of easy transportation

Inactive Publication Date: 2017-08-04
王来
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although radiofrequency hyperthermia can heat deep tumors, it needs to be cooled with water to insulate the local area, and the subcutaneous fat will overheat and cause pain, resulting in hard joints and difficult operation
Ultrasonic focused hyperthermia has strong penetrating power and can treat deep tumors. However, due to the limitation of ultrasound itself, it cannot penetrate gas-containing tissues or bones, so its application range is greatly limited.
To sum up, these tumor hyperthermia methods have disadvantages such as limited heating effect, difficulty in conformal heating range, low temperature detection accuracy, and possible overheating damage to healthy tissues. Therefore, the final targeted killing efficiency is not high, and residual tumor cells appear. , transfer and recurrence
[0004] Therefore, how to heat the tumor target tissue in a directional way, and how to heat the tumor tissue to an effective killing temperature without damaging the normal tissue, and this key problem has not yet been solved well. In addition, the hyperthermia equipment based on the above method A common but complex structure, complex operation, high treatment costs

Method used

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  • Tumor thermotherapy pill and preparation device and process thereof
  • Tumor thermotherapy pill and preparation device and process thereof

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Experimental program
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Effect test

Embodiment 1

[0044] Such as figure 1 As shown, the present invention provides a tumor hyperthermia pill, comprising: a core drug 1; and a shell that wraps the core drug 1; wherein the core drug 1 is a substance that reacts exothermicly with water.

[0045] Specifically, the exothermic reaction substance when encountering water includes: one or more of inorganic basic compounds, organic basic compounds, inorganic acidic compounds, organic acidic compounds, alkali metals or alkali metal compounds; and The substances include: one or more of inorganic oil, organic oil, inorganic high molecular polymer or organic high molecular polymer.

[0046] The average diameter of the core drug 1 and the surrounding shell is, for example but not limited to, between 1 nm and 5 mm, and its shape is spherical, strip or random.

[0047] The function of the core drug 1 is to release heat, and the volume, quality and composition of the drug amount are controlled according to the effect of treatment required. Th...

Embodiment 2

[0050] The present invention utilizes microfluidic technology to prepare low-cost pills (i.e., tumor hyperthermia pills), and obtains high killing efficiency, no damage to surrounding tissues, and Tumor hyperthermia pills that are easy to transport, store and operate.

[0051] Such as figure 2 As shown, the present invention also provides a pill preparation device, comprising:

[0052] A microfluidic chip 3 for preparing encapsulated pills, and

[0053] A core drug injection device and a shell material injection device connected to the microfluidic chip 3; wherein

[0054] The output end of the microfluidic chip 3 is connected to a curing device, and the shell of the wrapped pill entering the curing device is cured.

[0055]The microfluidic chip 3 includes: a first microfluidic channel 301 communicated with the core drug injection device, a second microfluidic channel 302 communicated with the shell material injection device, and the end of the first microfluidic channel 3...

Embodiment 3

[0062] On the basis of embodiment 2, the present invention provides a kind of pill preparation process, comprising:

[0063] After the core drug 1 is coated by the shell solution 2a, it is solidified.

[0064] The pill preparation process is realized by a pill preparation device, that is, the pill preparation device includes: a microfluidic chip 3 for preparing wrapped pills, and a core drug injection device and a shell material injection device connected to the microfluidic chip 3 ; Wherein the output end of the microfluidic chip 3 is connected to the curing device, and the shell of the wrapped pill entering the curing device is cured.

[0065] The microfluidic chip 3 includes: a first microfluidic channel 301 communicated with the core drug injection device, a second microfluidic channel 302 communicated with the shell material injection device, and the end of the first microfluidic channel 301 is a The injection nozzle 301a is connected to the side wall of the second micro...

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Abstract

The invention relates to a tumor thermotherapy pill and a preparation device and process thereof. The tumor thermotherapy pill comprises core drug and a shell wrapping the core drug, and the core drug is a reactive matter releasing heat when encountering water. Heat for killing tumor cells (tissue) is provided by the core drug suitable for generating thermal reaction when encountering water, and the heat-releasing drug (core drug) is wrapped by an inert material, thereby being easy to transport, store and inject. Further, in the process of treatment by injecting the drug, the core drug is protected by the shell wrapping the same, so that heat-releasing reaction does not occur immediately, and no damage is caused to normal tissue through which an injection device passes.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a tumor hyperthermia pill, a preparation device and a preparation process thereof. Background technique [0002] Tumor hyperthermia is one of the interventional therapies besides surgical resection, radiotherapy and chemotherapy, although surgical resection, radiotherapy and chemotherapy are considered to be the most effective treatments. However, surgical resection will cause limb damage, and radiotherapy and chemotherapy will cause physical and mental damage due to excessive side effects. All these methods will inevitably reduce the survival rate and quality of life of patients. Therefore, tumor hyperthermia methods with minimal invasiveness, low toxicity and side effects, and directional treatment have attracted attention and been applied. Tumor hyperthermia is to increase the temperature of tumor tissue and its surrounding tissue through various heating methods. When the tum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/28A61K9/30A61P35/00
CPCA61K41/0052A61K9/0019A61K9/2813A61K9/282A61K9/2833
Inventor 王来仲崇高唐红慧
Owner 王来