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Plastic packaged nutritional liquids comprising HMB

A technology for plastic packaging and nutrient solution, applied in the field of nutrient solution, can solve the problems of reducing the commercial acceptability of nutrient solution

Inactive Publication Date: 2017-08-22
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Any of these adverse effects can significantly reduce the commercial acceptability of the nutrient solution

Method used

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  • Plastic packaged nutritional liquids comprising HMB
  • Plastic packaged nutritional liquids comprising HMB
  • Plastic packaged nutritional liquids comprising HMB

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] This exemplifies the buffering effect of HMB in reconstituted PediaSure® powder (nutritional emulsion). A known amount of dilute hydrochloric acid was added to a control sample of reconstituted PediaSure® powder (Abbott Laboratories, Columbus Ohio) (without HMB), and a sample of reconstituted PediaSure® powder with HMB at 5.17 g / Kilograms of reconstituted powder are fortified. HMB used to fortify HMB-containing samples was prepared via cation exchange removal of calcium from calcium HMB monohydrate. Before free HMB was added to the samples, its pH was adjusted to 6.7 with sodium hydroxide. An equimolar amount of sodium was added to the control sample as sodium chloride. With continuous stirring, the pH of each sample was measured 1 minute after the addition of hydrochloric acid. From the pH reading, calculate the hydrogen ion concentration (H+). The results are shown in the table below:

[0112]

[0113] The data in the table above show a measurable buffering e...

Embodiment 2

[0115] This exemplifies the buffering effect of HMB in reconstituted PediaSure® powder (nutritional emulsion). A known amount of hydrogen peroxide (1.32 mg / kg reconstituted powder) was added to a control sample of reconstituted PediaSure® powder (without HMB), and a sample of reconstituted PediaSure® powder with HMB at 5.17 g / kg reconstituted powder for fortification. HMB used to fortify samples including HMB was prepared via cation exchange removal of calcium from calcium HMB monohydrate. Before free HMB was added to the samples, its pH was adjusted to 6.7 with sodium hydroxide. An equimolar amount of sodium was added to the control sample as sodium chloride. With continuous stirring, the pH of each sample was measured after 1 hour at room temperature, and the [H+] concentration was calculated from the pH value. The results are shown in the table below:

[0116] in H 2 o 2 time since joining

[0117] The data in the table above show a measurable buffering ef...

Embodiment 3

[0119] This exemplifies the buffering effect of HMB in ready-to-drink liquids as nutritional emulsions. Commercially available Ensure® Plus (Sample #1) (Abbott Laboratories, Columbus, Ohio) and Sample #2 (based on Ensure® Plus and included 6.5 grams calcium HMB / kg emulsion and 2.380 Buffering capacity of liquid nutritional emulsion in grams (g) of phosphate / kg of emulsion). The results are shown in the table below:

[0120] Added acid or base Sample #1 (without HMB) Sample #2 (with HMB) HCl (mmol) required to lower the pH of 100 mL from 6.0 to 3.0 13.9 21.0 NaOH (mmol) required to raise the pH of 100 mL from 7.0 to 11.0 9.62 9.04

[0121] As shown in the table above, Sample #2, which included calcium HMB, was significantly more resistant to pH drop than Sample 1 . By resisting pH decrease (via acid addition) over pH increase (via NaOH addition), this data shows that HMB confers a selective buffering effect on nutrient solutions. This feature ...

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Abstract

The invention relates to a plastic packaged nutritional liquids comprising HMB. Disclosed are nutritional compositions comprising a plastic package and a nutritional liquid contained therein, wherein the nutritional liquid comprises beta-hydroxy-beta-methylbutyrate (HMB) and at least one of fat, protein, and carbohydrate. It has been found that HMB provides a buffering effect in the nutritional liquid to thus minimize an acidic pH shift that is more prevalent in plastic packages, and thus help maintain product stability over time.

Description

[0001] This application is a divisional application of Chinese patent application 201180007418.X "Plastic Packaged Nutrient Solution Containing HMB" filed on January 28, 2011. technical field [0002] The present disclosure relates to a plastic packaged nutritional solution comprising β-hydroxy-β-methylbutyric acid (HMB). Background technique [0003] There are many different types of packaged nutritional solutions suitable for oral administration to humans, the compositions often comprising various combinations of macro- and micronutrients. Many of these packaged liquids are formulated as milk or protein based emulsions for use as a sole or supplemental source of nutrients. These packaged emulsions are typically manufactured as oil-in-water emulsions containing fats, proteins, carbohydrates, vitamins and minerals, some examples of which include ENSURE® Nutritional Liquid and GLUCERNA® Shakes available from Abbott Laboratories, Columbus, Ohio USA. [0004] During the manu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/10B65B55/14B65B55/10A61L2/07A61L2/18A61L2/22A61L101/22
CPCA61L2/07A61L2/186A61L2/22B65B55/10B65B55/14A23V2002/00A61L2202/23A23V2250/628A23V2250/5114A23V2250/5488A23V2250/5424A23V2250/54246A23V2250/54252A23V2250/1842A23V2250/708A23V2250/702A23V2250/71A23V2250/712A23V2250/5036A23V2250/161A23V2250/16A23V2250/5054A23V2250/1618B65B55/18A23L33/40A23L33/10
Inventor P.W.约翰斯A.肯斯勒
Owner ABBOTT LAB INC