Preparation method of rhizoma paridis total saponin self-microemulsifying granules

Abstract

The invention discloses a preparation method of rhizoma paridis total saponin self-microemulsifying granules. The preparation method comprises the following steps: weighing 7.0 g of propylene glycol mono-octoate, 1.5 g of Tween-80 and 1.5 g of propylene glycol, magnetically stirring and mixing uniformly, and slowly adding 0.1 g of rhizoma paridis total saponin, magnetically stirring to completely dissolve medicines to obtain a rhizoma paridis total saponin self-microemulsifying medicine release system; weighing 50.0 g of microcrystalline cellulose, putting the microcrystalline cellulose into a mortar, adding 10.0 g of the obtained rhizoma paridis total saponin self-microemulsifying medicine release system solution into the mortar slowly and dropwise, stirring uniformly while adding, adding a PVP K30 solution of 10.0 percent to prepare a soft material, and stopping adding the liquid when the soft material can be held by hands into a roll and can be dispersed through slight pressurization; and sieving and pelletizing the obtained soft material, drying and performing size stabilization to obtain the rhizoma paridis total saponin self-microemulsifying granules. The rhizoma paridis total saponin is prepared into the self-microemulsifying granules, so the in vitro dissolution speed of the medicines can be remarkably increased, and the preparation process is simple and feasible.

Description

technical field [0001] The invention relates to the field of medicament preparation, in particular to a preparation method of total saponin self-microemulsified granule of papaya polyphylla. Background technique [0002] Paris Polyphylla (Paris Polyphylla) belongs to the Liliaceae (Jiliaceae), also known as fleas. In recent years, pharmacological studies have shown that the total saponins of Paris Polyphylla have an inhibitory effect on tumors. [1] , and among the total saponins of papaya, papaya saponin I and papaya saponin II have the strongest antitumor activity. At present, Chonglou preparations in clinical application have various dosage forms such as powders, formulations, lotions, aerosols, ointments, etc., but most of them are medicinal powders or extracts directly used in medicine, the dosage forms are backward, and the content of active ingredients in the preparations is low. Bioavailability Poor degree. Because the total saponins of Parisia saponins are fat-solu...

AI Technical Summary

Problems solved by technology

At present, Chonglou preparations in clinical application have various dosage forms such as powders, formulations, lotions, aerosols, ointments, etc., but most of them are medicinal powders or extracts directly used in medicine, the dosage forms are backward, and the content of active ingredients in the preparations is low. Bioavailability degree difference

Because the total saponins of Parisia saponins are fat-soluble components, their common solution preparations have disadvantages such as poor absorption and low bioavailability, which seriously affect the clinical efficacy of the drug

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