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Recombinant H7 hemagglutinin and application thereof

A technology of hemagglutinin and sequence, applied in the field of hemagglutinin, can solve problems such as reducing H7N9 virus

Inactive Publication Date: 2017-09-22
吴夙钦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention provides a recombinant H7 hemagglutinin, which improves the lack of specially prepared and expensive experimental facilities in the prior art, and reduces the possibility of H7N9 virus becoming a national pandemic

Method used

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  • Recombinant H7 hemagglutinin and application thereof
  • Recombinant H7 hemagglutinin and application thereof
  • Recombinant H7 hemagglutinin and application thereof

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Embodiment Construction

[0022] Various embodiments of the present invention will be described in detail below and illustrated with accompanying drawings. In addition to these detailed descriptions, the present invention can also be widely implemented in other embodiments, and any easy substitution, modification, and equivalent change of any of the described embodiments are included in the scope of the present invention and defined by the scope of the claims. prevail. In the description of the specification, many specific details are provided in order to enable readers to have a more complete understanding of the present invention; however, the present invention may still be practiced under the premise of omitting some or all of the specific details. Also, well-known steps or components have not been described in detail in order to avoid unnecessarily limiting the invention. The same or similar components in the drawings will be denoted by the same or similar symbols. It should be noted that the dra...

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Abstract

A recombinant H7 hemagglutinin comprises a H7 hemagglutinin protein domain, a GCN4-pII trimerization motif, and a His-tag sequence. This recombinant H7 hemagglutinin is produced by Chinese hamster ovary cells. The recombinant H7 hemagglutinin is supplemented with a pharmaceutically acceptable adjuvant to prepare a vaccine against the H7N9 virus. This vaccine can induce specific antibodies to enhance immunity against the H7N9 virus.

Description

technical field [0001] The present invention relates to a hemagglutinin of influenza virus, in particular to the recombinant H7 hemagglutinin produced by Chinese hamster ovary cell line, and its use to prepare a vaccine composition capable of inducing specific antibodies. Background technique [0002] Type A influenza virus (Influenza A viruses) can infect humans, mammals and birds, and is a common infectious disease between humans and animals. The influenza A genome has an 8-segmented negative-sense RNA nucleocapsid, and its virion is pleomorphic and has envelope proteins, which contain two glycoproteins: Hemagglutinin (referred to as hemagglutinin, HA) and neuraminidase (neuraminidase, NA), there are matrix protein (M1) and membrane protein (M2) inside. Among them, HA can promote the production of protective neutralizing antibodies (neutralizingantibody). [0003] The generation of novel influenza virus is caused by segmented genes, which cause antigenic changes through ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/11C12N15/85A61K39/145A61P31/16
CPCA61K39/12C07K14/005C12N2760/16122C12N2760/16134A61K39/39A61K2039/543A61K2039/55505A61K2039/55511A61K2039/55561A61K2039/55566A61K2039/575A61P31/16A61P37/04C07K2319/21C07K2319/42C07K2319/73C12N2760/16151A61K39/145C12N7/00
Inventor 吴夙钦刘玟君陈廷轩
Owner 吴夙钦