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A kind of porphyrin liposome radiopharmaceutical 64cu-texaphyrin NPs and its preparation method

A technology of radiopharmaceuticals and porphyrin lipids, applied in the direction of in vivo radioactive preparations, radioactive physical shapes, radioactive carriers, etc., can solve the problems of in vivo application without Texas porphyrin radiolabeling

Active Publication Date: 2018-08-10
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no direct labeling methods of Texas porphyrin liposomes using positron nuclides, and no in vivo application of Texas porphyrin radiolabels in the field of PET imaging.

Method used

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  • A kind of porphyrin liposome radiopharmaceutical 64cu-texaphyrin NPs and its preparation method
  • A kind of porphyrin liposome radiopharmaceutical 64cu-texaphyrin NPs and its preparation method
  • A kind of porphyrin liposome radiopharmaceutical 64cu-texaphyrin NPs and its preparation method

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Embodiment 1

[0029] 1 Material:

[0030] Hydrogenated soybean phospholipids (HSPC) and cholesterol (Cholesterol) were purchased from Shanghai Avete Pharmaceutical Technology Co., Ltd. (AVT). Texas porphyrin phospholipids were provided by the Department of Medical Biophysics, University of Toronto. Distearoylphosphatidylethanolamine-polyethylene glycol 2000 was purchased from Avanti Polar Lipids, USA. Copper acetate monohydrate was purchased from J&K Bailingwei Technology Co., Ltd., China. Positron nuclides 64 Cu was produced in the Department of Nuclear Medicine, Peking University Cancer Hospital. Acetic acid and ammonium acetate were purchased from Sigma-Aldrich, USA.

[0031] 2 Methods and results

[0032] 2.1 Radiochemical purity method

[0033] ITLC method: Agilent ITLC-SG silica gel glass fiber paper was selected and cut into rectangular paper strips with a length of 10 cm and a width of 1.5 cm. Spot the sample at 1 cm, expand it with 1% EDTA-2Na aqueous solution, expand it to ...

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Abstract

The present invention discloses a porphyrin liposome radio pharmaceutical <64>Cu-Texaphyrin NPs and a preparation method thereof, wherein the porphyrin liposome radio pharmaceutical <64>Cu-Texaphyrin NPs comprises a nanometer material and a radionuclide <64>Cu, the nanometer material is a liposome nanometer liposome formed from Texaphyrin-lipid, ie., Texahyrin NPs, and the radionuclide <64>Cu label can achieve the self-labeling without the linking of any small molecule multifunctional chelating agents so as to form the <64>Cu-Texaphyrin NPs. According to the present invention, the porphyrin liposome radio pharmaceutical <64>Cu-Texaphyrin NPs can be concentrated into the tumor site having the EPR effect in the passive target manner, and can perform imaging diagnosis and detection on tumors or other diseases having the EPR effect by using the PET imaging technology of nuclear medicine.

Description

technical field [0001] The invention relates to radiopharmaceuticals for tumor diagnosis, in particular to a porphyrin liposome radiopharmaceutical 64 Cu-Texaphyrin NPs and methods for their preparation. Background technique [0002] Molecular probes are one of the core research contents of molecular imaging technology. In recent years, the research on molecular probes for different imaging modalities labeled with radionuclides, fluorescent dyes, paramagnetic and superparamagnetic materials, etc. has grown geometrically. Compared with traditional small-molecule probes, nano-molecular probes have the characteristics of integrating multiple functions and designs, drug packaging and delivery, long circulation time in the body, and the ability to passively target tumors through the EPR (Enhanced Permeability and Retention effect) effect. It can increase the anti-cancer effect of the drug and reduce the toxic and side effects. Based on the multifunctional properties of nano-mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/12A61K51/04A61K103/00
CPCA61K51/0485A61K51/1234
Inventor 王凡史继云高翰男梁晓龙贾兵
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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