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Decomposition inhibitor of hyaluronic acid containing sodium 2-mercaptoethanesulfonate and composition comprising same

A technology of sodium mercaptoethanesulfonate and hyaluronic acid, which is used in skin care preparations, drug combinations, anhydride/acid/halide active ingredients, etc., can solve the limitations of hyaluronic acid, and does not specify 2-mercaptoethyl Sodium sulfonate, no mechanism of action identified, etc.

Active Publication Date: 2021-04-20
PHARMARES PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, although U.S. Patent No. 2014-142063 describes that thiol additives such as sodium 2-mercaptoethanesulfonate can promote the formation process of hydrogels and promote the decomposition of hydrogels that have formed, it does not specify How sodium 2-mercaptoethanesulfonate works on the skin or skin tissue
[0006] In the prior art, there is a method of delaying the decomposition of hyaluronic acid by adjusting the ratio of the gel and sol that make up the hyaluronic acid filler in order to prevent the decomposition of hyaluronic acid, but this method is effective in preventing hyaluronic acid. There are limitations in the decomposition of uric acid
[0007] In addition, although it is known that the STYLAGE filler developed by the French company Vivacy can delay the decomposition of hyaluronic acid by adding mannitol as an antioxidant to suppress active oxygen, but there is no research on this. The specific mechanism of action has been clarified, and the use of antioxidants such as mannitol to inhibit reactive oxygen species cannot be considered as a method that can directly inhibit the decomposition of hyaluronic acid.

Method used

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  • Decomposition inhibitor of hyaluronic acid containing sodium 2-mercaptoethanesulfonate and composition comprising same
  • Decomposition inhibitor of hyaluronic acid containing sodium 2-mercaptoethanesulfonate and composition comprising same
  • Decomposition inhibitor of hyaluronic acid containing sodium 2-mercaptoethanesulfonate and composition comprising same

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Embodiment 1

[0077] After adding the enzyme solution to each sample of Example 1 and Comparative Examples 1-2, the reaction was carried out at 37° C. and 80 rpm for 30 minutes. 1 ml of 0.1N HCl solution was added to each sample, and vigorous stirring was performed for 10 seconds to stop the reaction. After the stirring was completed, 1 ml of 0.1N NaOH and PBS were added to all the samples for neutralization, so that the total amount reached 4 ml. After filtering the prepared 4 ml solution with a membrane having a pore diameter of 0.2 μm, it was stored in cold storage.

[0078] 3. Quantitative-Carbazole Analysis

[0079]React with carbazole to determine the content of glucuronic acid. Specifically, accurately measure 0.170g of Example 1, Comparative Example 1 or Comparative Example 2 respectively, dissolve them in water respectively to make 100g of aqueous solution, accurately measure 10g of said aqueous solution, and add water to it to 200g precisely Then, this was used as a sample solu...

reference example 1

[0102] [Reference Example 1] Preparation of Dosage Form Example 1 and Comparative Dosage Form Examples 1-2

[0103] According to the composition of the following Table 5, dosage form example 1 and comparative dosage form examples 1-2 (unit: weight %) were prepared.

[0104] [table 5]

[0105]

[0106]

[0107] (1) The water phase components (1-8) are uniformly mixed at room temperature.

[0108] (2) Heat the ethanol phase components (9-12) to 50-55° C., dissolve and mix them uniformly.

[0109] (3) Add (1) to (2) while stirring, and dissolve uniformly.

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Abstract

The present invention relates to a composition for inhibiting the decomposition of hyaluronic acid or a derivative thereof, and more particularly, to a hyaluronic acid or a hyaluronic acid whose resistance to hyaluronidase activity is increased by containing sodium 2-mercaptoethanesulfonate. A composition for inhibiting decomposition of a derivative, and a composition for in vivo administration or cosmetic surgery containing the composition for inhibiting decomposition and hyaluronic acid or a derivative thereof, especially a composition for repairing in vivo tissue.

Description

technical field [0001] The present invention relates to a composition for inhibiting the decomposition of hyaluronic acid or its derivatives, and more specifically, to hyaluronic acid or its derivatives having increased resistance to hyaluronidase activity by containing sodium 2-mercaptoethanesulfonate. Decomposition inhibitors of derivatives, and compositions for living body administration or cosmetic plastic surgery, especially compositions for living tissue repair, containing the decomposition inhibitors and hyaluronic acid or derivatives thereof. Background technique [0002] Hyaluronic acid is a kind of complex polysaccharides composed of amino acids and uronic acids, and is a polymer compound with a molecular weight of 200,000 to 400,000 that is alternately linked in chains with N-acetylglucosamine and glucuronic acid. . As the main component of the extracellular matrix, it not only participates in the maintenance of water, the maintenance of the intercellular space, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/46A61Q19/02A61Q19/08
CPCA61K8/466A61Q19/02A61Q19/08A61K8/46A61K9/00A61P17/00A61K9/0019A61K31/185
Inventor 韩址瑗权珉贞朴元锡高现珠阿泳昌金赫赵成衍洪性宇
Owner PHARMARES PROD