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Veterinary amoxicillin dry suspension and preparation method thereof
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A technology of amoxicillin drying and amoxicillin, which is applied in the field of veterinary amoxicillin medicine, can solve the problems of large dosage, impact on food safety, reagent residue, etc., achieve good redispersibility, good suspension effect, and reduce residue Effect
Active Publication Date: 2020-06-02
HEBEI LIHUA PHARMA CO LTD
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Problems solved by technology
In order to meet the quality requirements of the suspension, it is often necessary to use a large amount of suspending auxiliary materials to achieve the suspension and dispersion of amoxicillin powder. Due to the large amount of amoxicillin used in animals, pigs will ingest a large amount of auxiliary materials when using the drug , causing reagent residues and affecting food safety
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Embodiment 1
[0024] This embodiment relates to veterinary amoxicillin dry suspension and its preparation.
[0029] a1. Grind amoxicillin, pass through a 200-mesh sieve, and then dry at normal pressure and 60°C for 5 hours; dry lactose at normal pressure and 60°C for 4.5 hours until the water content is less than 2%;
[0030] a2, grind suspending agent, cross 100 mesh sieve; Grind flocculant, cross 100 mesh sieve; Grind dispersant, cross 100 mesh sieve; Add suspending agent, flocculant and dispersant after sieving to mixer in proportion, After mixing for 30 minutes, the resulting mixture w...
[0036] a1. Grind amoxicillin, pass through a 200-mesh sieve, and then dry under normal pressure and 60°C for 4 hours; dry lactose under normal pressure and 60°C for 4 hours until the water content is lower than 2%;
[0037] a2, grind suspending agent, cross 100 mesh sieve; Grind flocculant, cross 100 mesh sieve; Grind dispersant, cross 100 mesh sieve; Add suspending agent, flocculant and dispersant after sieving to mixer in proportion, After mixing for 40 minut...
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Abstract
The invention discloses livestockamoxicillin for suspension. The livestockamoxicillin for suspension comprises the following raw material components of, by mass, 10-15 parts of amoxicillin, 1-5 parts of a suspending agent, 1-5 parts of a flocculating agent, 10-20 parts of a dispersing agent and 100 parts of lactose, wherein the suspending agent comprises at least one of sodiumcarboxymethyl cellulose, Arabic gum and sodium alginate; the flocculating agent comprises at least two of disodium hydrogen phosphate, aluminum hydroxide and aluminum chloride; and the dispersing agent comprises at least two of polyethylene glycol 4000, polyethylene glycol 6000 and povidone. The obtained amoxicillin for suspension conforms to the standard requirement of the high-quality suspending agent, that is, the suspending effect is good, the flowability is good, and the stability is high, and further has good pharmaceutical effects and medicinal safety, and the quality safety of meat products is ensured. The preparation method of the livestock amoxicillin for suspension is simple in technology procedure, and the quality of the amoxicillin for suspension can be significantly improved by limiting the drying degree and the mixing order of each raw material component.
Description
technical field [0001] The invention relates to the technical field of veterinary amoxicillin medicines, in particular to a veterinary amoxicillin dry suspension and a preparation method of the veterinary amoxicillin dry suspension. Background technique [0002] Amoxicillin, a white powder, is the most commonly used semi-synthetic penicillin broad-spectrum β-lactamantibiotics, slightly soluble in water, almost insoluble in ethanol, its bactericidal effect and ability to penetrate cell membranes, and in acid It is stable under conditions, and the gastrointestinal absorption rate can reach 90%. It is often used to treat diseases such as animal respiratory diseases, Haemophilus parasuis disease and postpartum infection, and the curative effect is remarkable. Amoxicillin is widely used and is one of the top ten drugs commonly used in pig farms. Its main dosage forms include premixes, solid dispersions, dry suspensions, etc. Premixes and dispersants are administered by mixing ma...
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